Global ETD Search

Small molecule 3C-like protease inhibitors of Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronaviruses (SARS-CoV, SARS-CoV-2) and norovirus (NV)

Thennakoon Mudiyanselage, Athri Dewmina Rathnayake2020

wichita-thes

Coronavirus Proteases as Therapeutic Targets: Development of Biosensors to Detect Inhibition of Protease Activity and Separation of the Multiple Functions of Coronavirus Papain-Like Proteases

Kilianski, Andrew2016

… I utilized two approaches targeting the proteases encoded within all coronaviruses. The papain-like protease and 3C-like protease of coronaviruses are responsible for cleaving viral polyproteins early during infection, and this step is required for viral replication. To quantitatively …

loyola-thes Repository record for Coronavirus Proteases as Therapeutic Targets: Development of Biosensors to Detect Inhibition of Protease Activity and Separation of the Multiple Functions of Coronavirus Papain-Like Proteases (opens in a new tab)

Charakterisierung der Substratspezifität coronaviraler 3C-like-Proteasen

Hegyi, AnnetteUniversität Würzburg

… in diesem Prozess haben die viruskodierten 3C-like-Proteasen, die aus diesem Grund attraktive Zielmoleküle für die Entwicklung anticoronaviraler Therapien darstellen. Eine wichtige Voraussetzung für die Entwicklung effektiver und selektiver Inhibitoren stellt die biochemische und …

wurz-thes Repository record for Charakterisierung der Substratspezifität coronaviraler 3C-like-Proteasen (opens in a new tab)