Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"3-hydroxy-3-methylglutaryl CoA reductase"”.
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Autocrine prolactin signaling in breast cancer cells leads to metabolic changes and therapeutic opportunities for anti-tumour and anti-bone metastatic treatment
… not explained by basal levels of cholesterol, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) or acetyl-CoA. In vivo, the drug showed a trend toward slowing the progression of the hPRL-secreting tumours and increasing bone mineral density when used in a therapeutic setting in immunodeficient …
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Combinatorial biochemistry of triterpene saponins in plants
… ligase, MAKIBISHI1 (MKB1), that targets 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), the enzyme catalyzing the rate-limiting step in the mevalonate pathway, for ubiquitin-mediated proteasomal degradation, thereby controlling saponin biosynthesis.
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HMGCR Pathway Mediates Cerebral-Vascular Stability and Angiogenesis in Developing Zebrafish
… analysis, I demonstrate a requirement for the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway in regulating developmental cerebral-vascular stabilization. A transient loss in HMGCR function induces ICH, characterised by progressive dilation of blood vessels, vascular permeability and …
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Membrane Domain of Plant 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase: Targeting, Topology, and Function
… in isoprenoid biosynthesis is catalyzed by 3-hydroxy-3-methylglutaryl CoA reductase (HMGR, EC 1.1.1.34). In plants, HMGR is encoded by small gene families whose members are differentially expressed. In tomato, hmg2 was previously isolated and sequenced. We report the isolation and sequence …
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Functional analyses of tomato 3-hydroxy-3-methylglutaryl coenzyme a reductase (HMGR) genes in transgenic plants engineered for altered HMGR expression
3-Hydroxy-3-methylglutaryl CoA reductase (HMGR, EC 1.1.1.34) mediates the first regulatory step (HMG-CoA reduction to mevalonate) in isoprenoid biosynthesis. The tomato genome contains at least four differentially regulated hmg isogenes encoding HMGR. Functions of tomato hmg2 in defense responses …
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Role of Subcellular Differentiation in Plant Disease Resistance
3-Hydroxy-3-methylglutaryl CoA reductase (HMGR, EC 1.1.1.34) catalyzes the reaction from hydroxymethylglutaryl CoA to mevalonate in the isoprenoid pathway. In solanaceous plants, one class of endproducts of the pathway are sesquiterpenoid phytoalexins, antibiotic compounds produced by plants in …
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Breaking the MF curse: the regulatory role of the Methyl farnesoate – MEKRE93 pathway in crustacean molting
… interaction between the steroid hormone 20-hydroxyecdysone (20-E) and the sesquiterpenoid juvenile hormone (JH) control insect molting and development, respectively. On the other hand, crustacean molting is primarily regulated through the endocrine crosstalk between 20-E and the neuropeptide …
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IN VITRO EFFECT OF STATINS ON STREPTOCOCCUS MUTANS, STREPTOCOCCUS SANGUIS, AND STREPTOCOCCUS SALVARIUS
… that lower cholesterol levels by inhibiting 3-hydroxy-3-methylglutaryl-CoA reductase, a rate limiting enzyme in the human mevalonate pathway of which cholesterol in the biosynthetic end product. The mevalonate pathway is an important cellular metabolic pathway present in many bacteria. Hence, …