"3-d]PYRIMIDINE" · 7 results · Global ETD Search

Synthesis Of Substituted Pyrrolo[2,3-D]Pyrimidines As Microtubule-Binding Agents and HSP90 Inhibitors

Lin, Lu2018

… on the synthesis of substituted pyrrolo[2, 3-d]pyrimidines as potential anticancer agents that act via microtubule inhibition or HSP90 inhibition.. Microtubule-binding agents are effective against a broad range of tumors and lymphomas and have been common components of combination …

duquesne Repository record for Synthesis Of Substituted Pyrrolo[2,3-D]Pyrimidines As Microtubule-Binding Agents and HSP90 Inhibitors (opens in a new tab)

Bicyclic Heterocyclic Systems Derived from 1, 3, 4-Trisubstituted Pyridines

Bradley, ArthurAston University1973

… are employed for the synthesis of pyrido[4, 3-d] pyrimidine 6-oxides. Condensation of 4-aminonicotinic acid 1-oxide with formamide and urea gives the corresponding pyridopyrimidinones. Treatment of 4-aminonicotinic acid 1-oxide with aroyl halides gives the appropriate 2-arylpyrido[4, 3-d] [1, …

aston Repository record for Bicyclic Heterocyclic Systems Derived from 1, 3, 4-Trisubstituted Pyridines (opens in a new tab)

Classical Antifolates: Synthesis of 5-Substituted, 6-Substituted and 7-Substituted Pyrrolo[2,3-d]Pyrimidines as Targeted Anticancer Therapies

Wang, Yiqiang2018

… 5-, 6- and 7-substituted pyrrolo[2, 3-d]pyrimidines were designed and synthesized. Extensive structure modifications of the pyrrolo[2, 3-d] pyrimidine scaffold were investigated to determine selective transport via FR or/and PCFT and tumor targeted antifolates with GARFTase or multiple …

duquesne Repository record for Classical Antifolates: Synthesis of 5-Substituted, 6-Substituted and 7-Substituted Pyrrolo[2,3-d]Pyrimidines as Targeted Anticancer Therapies (opens in a new tab)

Alkilintų 5-cian-2-metilsulfanil-4(3H)-pirimidinonų sintezės ir ciklizacijos reakcijų tyrimas /

Stankevičiūtė, Živilė,Institutional Repository of Vilnius University2010

… to formation of ethyl 4-amino-2-methylsulfanylpyrimidine-5-carboxylate, while ring closure in alkaline media gives rise to a mixture of 5-cyano-2-methylsulfanyl-4(3H)-pyrimidinone (major product), small amounts of ethyl 4-amino-2-methylsulfanylpyrimidine-5-carboxylate and uncyclisized products …

vilnius Repository record for Alkilintų 5-cian-2-metilsulfanil-4(3H)-pirimidinonų sintezės ir ciklizacijos reakcijų tyrimas / (opens in a new tab)

Synthesis of Novel 6-Substituted and 5-Substituted Pyrrolo[2,3-D] Pyrimidine Antifolates as Targeted Anticancer Therapies

Li, Xinxin2019

… classical 6- substituted pyrrolo[2,3-d]pyrimidines and 5-substituted pyrrolo[2,3-d]pyrimidines as potential antifolates have been described. The design variations include: methylated thiophene regioisomers, fluorinated phenyl regioisomers, thionyl regioisomers on the side chain …

duquesne Repository record for Synthesis of Novel 6-Substituted and 5-Substituted Pyrrolo[2,3-D] Pyrimidine Antifolates as Targeted Anticancer Therapies (opens in a new tab)

Synthesis of novel 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as selective and potent anti-tumor agents

Karim, Mohammad2019

… five 5-substituted pyrrolo[2,3-d]pyrimidines have been designed, synthesized and characterized. Among them four are novel compounds and one is a previously reported compound. The previously reported compound has never been tested for FR/PCFT-GARFTase selectivity before, and …

duquesne Repository record for Synthesis of novel 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as selective and potent anti-tumor agents (opens in a new tab)

The Synthesis of pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as receptor tyrosine kinase inhibitors or tubulin inhibitors or inhibitors of dihydrofolate reductases and the development of inhibitors or inhibitors of dihydrofolate reductases and the development of metal-catalyzed cross-coupling reactions

Namjoshi, Ojas2019

Abstract withheld

duquesne Repository record for The Synthesis of pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as receptor tyrosine kinase inhibitors or tubulin inhibitors or inhibitors of dihydrofolate reductases and the development of inhibitors or inhibitors of dihydrofolate reductases and the development of metal-catalyzed cross-coupling reactions (opens in a new tab)

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