Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"3,4-methylenedioxymethamphetamine"”.
-
STUDIES ON THE ACUTE AND LONG-TERM EFFECTS OF MDMA (3,4- METHYLENEDIOXYMETHAMPHETAMINE)
3,4-Methylenedioxymethamphetamine (MDMA, “ecstasy”) is a popular recreational drug. Administration of MDMA to rats produces an acute, rapid release of cerebral 5-HT and dopamine and depletion of 5-HT. After an initial recovery, 5-HT concentrations then decline for 3-12 months due to neurotoxic loss …
-
Individual sensitivity to novelty and (+)-3,4-methylenedioxymethamphetamine: Roles for serotonin and GABA neurotransmission
… in humans exist to the subjective effects of 3,4-methylenedioxymethamphetamine (MDMA) and these differences are rooted, in part, in individual sensitivity to the drug effects, we utilized two animal models of increased sensitivity in the current studies. First, in a sensitization animal model we …
-
Thermoregulatory, behavioural and neurochemical effects of 3,4-methylenedioxymethamphetamine (MDMA) and related stimulant drugs.
3,4-Methylenedioxymethamphetamine (MDMA, ‘ecstasy’) is an amphetamine derivative widely used in rave party and club scenes. In some users, MDMA causes fatalities, most often due to acute hyperthermia which leads eventually to multi-organ failure. Other structurally related drugs, including …
-
Zur Neurotoxizität von Methylendioxyamphetaminen (Ecstasy) : akustisch evozierte Potentiale als Mass für das Funktionsniveau serotonerger Neuronenverbände im ZNS
… serotonergic systems after exposure to 3,4-methylenedioxymethamphetamine (MDMA, ecstasy). It has been suggested that a high loudness dependence of auditory evoked potentials (LDAEP) and, particularly, of the tangential N1/P2 source activity is associated with a low functioning of …
-
Non-acute Cognitive Sequelae Associated With Recreational Ecstasy Use: A Meta-analysis
… damage resulting from exposure to 3,4- methylenedioxymethamphetamine (MDMA, ecstasy). Yet, studies comparing the cognitive performance of human recreational ecstasy users to ecstasy naïve controls have produced inconsistent results. The present study is a meta-analysis of the …
-
Understanding the neuroadaptations underlying the effects of (+)-methylenedioxymethamphetamine [(+)-MDMA; ecstasy]: Implications for the serotonin 5-HT2A receptor and its binding partners
Repeated administration of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) induces “behavioral sensitization,” an enhancement of its behavioral effects. The molecular changes underlying behavioral sensitization may be linked to neuropsychological sequelae (e.g., depression, anxiety) seen upon …
-
Vulnerability to cognitive, neurotoxic and neuroinflammatory effects of toxins that induce Parkinson's disease after administration of amphetamine-related drugs in mice
… disease (PD) in amphetamine users. 3,4-Methylenedioxymethamphetamine (MDMA) is an amphetamine-related drug which may have neuroinflammatory and neurotoxic effects. The present study was aimed at evaluating in mice whether administration of MDMA during adolescence might influence …
-
Estradiol and MDMA affect the susceptibility and immune response to genital herpes and genital herpes immunization
… differences in vaccine efficacy. Meanwhile, 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) was abused by over 1.2 million Americans in 2007 and is popular in the dance club, rave and circuit party scenes. MDMA and other similar drugs are reportedly associated with increased incidence of …
-
The Role Of Sertonin And Vesicular Monoamine Transporters In The Adverse Responses To Methylenedioxymethamphetamine
3,4-(±)-Methylenedioxymethamphetamine (MDMA, Ecstasy) is a widely abused amphetamine derivative with potent stimulant properties. The neuropharmacological effects of MDMA are biphasic in nature. MDMA initially causes synaptic monoamine release, primarily of serotonin (5-HT), producing hyperthermia …
-
Impact of genetic variability in the serotonin transporter, Tryptophan Hydroxylase-2, and Serotonin 2A Receptors on MDMA Use and Impulsivity
Ecstasy [MDMA; (±)-3,4-methylenedioxymethamphetamine] is popular for positive effects including enhanced mood and empathy, despite potential deleterious physical and psychological consequences. The serotonin (5-HT) system plays a prominent role in the neurochemical and behavioral effects of MDMA, …
-
The Synthesis and Chemical Profiling of 3,4-Methylene-Dioxymethamphetamine (MDMA) and Analogues
… examines the organic impurity profiles of 3,4-methylenedioxymethamphetamine (MDMA) and its analogue methylone that were synthesised from uncontrolled ‘pre-precursors’. Methylone was synthesised from catechol by one synthetic route. Safrole was synthesised from catechol by two synthetic routes …
-
Glutamate and MDMA Neurobehavioral Toxicity
±-3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is a ring-substituted amphetamine derivative, and a popular psychoactive drug of abuse. This drug evokes a well-documented acute increase in the release of serotonin, dopamine, and acetylcholine, as well as persistent reductions in markers of …
-
MDMA for Treatment of PTSD [poster]
The purpose of this paper is to show the current success of using MDMA and psychotherapy to treat this devastating disorder.
-
Arbeitsgedächtnis und Merkfähigkeit bei Ecstasy-Konsumenten
Rationale: Ecstasy is a synthetic drug with neurotoxic effects on central serotonergic systems. Serotonin is involved in various cognitive tasks involving memory and speed of information processing. By means of a comprehensive cognitive test battery poorer cognitive performance of the ecstasy user …