Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 316 for “"3+3"”.
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Modified 3+3 Design for MTD Re-estimation
The 3+3 clinical trial design is one of the most popular dose-finding designs used in phase I oncology trials to identify the maximum tolerated dose (MTD) for new treatment regimens. While this design is widely used due to its simplicity , it has some notable limitations, including a maximum of six …
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Protein kinases that phosphorylate 14-3-3 isoforms
14 -3 -3 is an abundant, predominantly phospho-binding protein, intimately involved in the regulation of many diverse signal transduction events including cell cycle regulation, nucleo-cytoplasmic targeting of essential transcription factors and regulation of catecholamine synthesis. The 14 -3 -3 …
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Die Rolle der 14-3-3-Proteine beim Vorwärtstransport von Kaliumkanälen
Kaliumkanäle, die wie andere Ionenkanäle und Membrantransportproteine ein wichtiges Bindeglied zwischen dem extrazellulären bzw. luminalen Raum und dem Zellinneren darstellen, spielen eine Rolle in diversen zellulären Prozessen wie Aufrechterhaltung des Membranpotentials, Frequenz und Verlauf von …
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Regulation of human protein kinases and phosphatases by 14-3-3
The first part of my thesis shows that a previously-uncharacterised protein FAM122A and its paralogue FAM122C form stable stoichiometric complexes with the protein phosphatase 2A (PP2A) heterotrimer (AαB55αC). Moreover, the FAM122A–PP2A complex is active and contains methylated catalytic C subunit. …
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Regulation of Mammary Gland Development and Tumorigenesis By 14-3-3 Zeta
<p>Signaling pathways that play critical roles in organ development are often aberrantly regulated during cancer initiation and progression. 14-3-3z is overexpressed in more than 40% of breast cancers and is associated with poor patient prognosis. Therefore, the function of 14-3-3z in cancer and …
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Untersuchungen zur dynamischen Regulation der Interaktion von RGS7 mit dem Adapterprotein 14-3-3
Das System aus G-Protein gekoppeltem Rezeptor, heterotrimerem G-Proteinkomplex und seinen Effektoren nimmt eine entscheidende Rolle in der Weiterleitung von Signalen in allen höheren Lebewesen ein. Lange stellte sich die Frage, wie die insuffiziente Inaktivierung dieses Systems in vitro und in vivo …
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Purification of protein phosphatases and 14-3-3-binding proteins and their regulation by the cAMP–PKA pathway
Reversible protein phosphorylation is a highly conserved mechanism that regulates the majority of proteins in a eukaryotic cell. Protein phosphorylation has been implicated in various cellular processes including glycogen metabolism, cell cycle control, RNA splicing, DNA synthesis, muscle …
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Fiber-Optic Michelson Interferometer with Faraday Mirrors for Acoustic Sensing using a 3 × 3 Coupler and Symmetric Demodulation Scheme
For the past 40 years, acoustic sensing has been a major avenue for the growth of interfero- metric fiber-optic sensors. Fiber-optic acoustic sensors have found uses in military, commer- cial, and medical applications. An interferometric fiber-optic acoustic sensor is presented utilizing the …
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14-3-3 Zeta Overexpression Serves As A Novel Molecular Switch Turning Tgf-Beta From Tumor Suppressor to Tumor Promoter
<p>TGF-β plays an important role in differentiation and tissue morphogenesis as well as cancer progression. However, the role of TGF-β in cancer is complicate. TGF-β has primarily been recognized as tumor suppressor, because it can directly inhibit cell proliferation of normal and premalignant …
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Crosstalk of protein phosphorylation and lysine acetylation on 14-3-3 proteins and their applications in brassinosteroid signaling and photosynthesis
Protein phosphorylation and lysine acetylation are two important post-translational modifications (PTMs) in eukaryotes. However, the crosstalk between these two modifications is largely unknown. We demonstrated that both phosphorylation and lysine acetylation occurred to an Arabidopsis protein, …
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Design of Peptide Ligands for 14-3-3ε, and Exploring the Role of Residue Types in Ligand Recognition by 14-3-3 Proteins
The 14-3-3 family of proteins are implicated in various malignancies. In cutaneous squamous cell carcinoma (cSCC), overexpression of the 14-3-3ε isoform is associated with suppression of apoptosis. Like 14-3-3ε, the protein phosphatase cell division cycle 25 A (CDC25A) is over expressed and …
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The study of a 3 3-dimentional structure of the congenital anomalous stape stapes compared with normal s stape stapes using Micro Micro-CT
PURPOSE: There is limited information about the internal structure of congenital anomalous ossicles. Recently, Micro CT scanning technology has been applied to analysis of skeletal structure. The data of normal ossicles and pathologic ossicle destructed by cholesteatoma were reported in our …
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Trestní odpovědnost právnických osob
A# @ ; ! ' .' ! / + ! , > , ! = ! *+ ! + > ' - > ' ! / + *- ! = ! ! ! D ,3 + ! ' .' ! / + ! , - - > D ' *-. . 3 ! ' C! , ! - /- , *- - 6F ! > - 3 = ,3 -. ,/ ' .' ! / + ! , B - - ' ! > . > >- B - !+ ' / = - C * > > ' ! > -. - -* ,3 G +3 3 > ' * ! 3 * ! , - ! ! > 4 3= > - + ' 'C 'C ' ! ' .' ! / + ! , …
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Determining the effects of phosphorylation on AFAP-110 function
As there are over twenty potential PKC phosphorylation sites in AFAP-110 structure, deletional mutagenesis was employed to determine which regions of AFAP-110 are most likely to contain crucial sites for PKC phosphorylation. Our data indicate that functional PKC phosphorylation sites must be …
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Molecular mechanisms of acquired gemcitabine resistance in pancreatic cancer
Most pancreatic cancer patients receiving gemcitabine chemotherapy eventually develop resistance to gemcitabine. To improve survival and prognosis of pancreatic cancer patients, better understanding the mechanisms of gemcitabine resistance and discovery of new therapeutic targets are required. In …
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Bayesian Adaptive Designs for Early Phase Clinical Trials
Delayed toxicity outcomes are common in phase I clinical trials, especially in oncology studies. It causes logistic difficulty, wastes resources, and prolongs the trial duration. We propose the time-to-event 3+3 (T-3+3) design to solve the delayed outcome issue for the 3+3 design. We convert the …
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Proteomic identification of putative biomarkers of neo-adjuvant chemotherapy resistance in luminal (ER+) breast cancer
Background:Neoadjuvant chemotherapy is a standard treatment for locally advanced breast cancer however chemoresistance can be a major obstacle in ER+ cancers. Using comparative proteomic approaches (antibody microarray/AbMA and 2D-PAGE with MALDI-TOF/TOF MS) to investigate a pilot series of breast …
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