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Showing 1 to 20 of 167 for “"3'UTR"”.

  1. Mammalian gene regulation through the 3' UTR

    Nielsen, Cydney BrookeMassachusetts Institute of Technology2008

    The untranslated region (UTR) at the 30 end of a mammalian mRNA is typically rich with regulatory motifs that influence the stability, localization, translation and other properties of the message. We explored two classes of motifs, microRNA (miRNA) complementary sites and cleavage and …

    mit Repository record

  2. Regulation and Function of the Dscam1 Extended 3' UTR mRNA

    Peterson, Ryan2017

    … of APA. Specific function of these longer 3' UTR transcripts are largely unknown; however, because the 3' UTR can regulate transcript stability, translational efficiency, and localization, it is plausible that 3' UTR switching in nervous tissues may serve important biological functions. We …

    unr Repository record

  3. Functional analyses of ζ-crystallin binding to the 3'-UTR of glutaminase (GA) mRNA

    Ibrahim, Hend M. M., author, Curthoys, Norman P., advisor, Bamburg, James R., committee member, Laybourn, Paul, committee member, Stargell, Laurie A., committee member, Mykles, Donald L., committee memberColorado State University. Libraries2006

    … established that the 3'-untranslated regions (3'-UTR) of the 4.5 kb GA mRNA contains the 8-base adenylate-uridylate (AU) sequence that functions as a pH-responsive element (pHRE) The pHRE binds (ζ-crystallin /NADPH:quinone reductase (ζ-crystallin) with high affinity and specificity. Analysis of …

    colostate Repository record

  4. Deconvoluting Cell-Type Specific 3'UTR Isoform Expression in the Adult and Developing Cerebellum

    Jereb, Saša

    <p>Alternative polyadenylation has been implicated in the regulation of mRNA translation and stability, as well as mRNA and protein localization. However, it is unclear to what extent alternative polyadenylation regulates these processes uniquely in specific cell types. Using a newly developed …

    rockefeller Repository record

  5. Characterisation of the 3'-UTR of the COL5A1 gene: implication for musculoskeletal soft tissue injuries

    Laguette, Mary-Jessica NancyMRC/UCT RU for Exercise and Sport Medicine2015

    … C/T) within the 3'-untranslated region (UTR) of COL5A1 is associated with chronic Achilles tendinopathy (TEN) and other soft tissue injuries as well as exercise-related phenotypes. These phenotypes are directly or indirectly associated with the mechanical properties of musculoskeletal …

    cape-town Repository record

  6. NOTCH1 3’UTR Mutationen in der CLL: Inzidenz in jüngeren Patienten und Auswirkung auf die NOTCH1 mRNA

    Pittrof, AnselmUniversität Ulm

    ulm-diss Repository record

  7. Regulation of mRNA expression through 3’ UTR sequences of IL6 gene in amino acid-deprived HeLa cells

    강, 정희2012

    … cytokines. Here, it was investigated whether 3’UTR of IL6 mRNA played a role in IL6 induction through cellular stress responses. In the studies with GFP-reporter containing 3’UTR of IL6 mRNA, it was elucidated that 3’UTR contributed to increase of IL6 mRNA after amino acid-starvation, and its …

    ajou Repository record

  8. Characterization of the instability elements present within the 3' UTR of the glutaminase mRNA in WKPT kidney cells

    Lee, Yeon Jean, author, Curthoys, Norman P., advisor, Bamburg, James R., committee member, Laybourn, Paul, committee member, Suchman, Erica, committee member, Wilusz, Jeffrey, committee memberColorado State University. Libraries2006

    During metabolic acidosis, the level of glutaminase (GA) is increased 8-fold within the renal proximal convoluted tubule. This adaptation contributes to the ability of the kidney to generate NH4+ and HCO3- ions from glutamine to facilitate the excretion of acids and partially restore acid-base …

    colostate Repository record

  9. The regulation of the COL5A1 gene via the 3'-UTR and its impact on Achilles tendinopathy andother exercise-related phenotypes

    Abrahams, YoonusDepartment of Biological Sciences2013

    The regulation of the COL5A1 gene via the 3'-UTR and its impact on Achilles tendinopathy andother exercise-related phenotypes

    cape-town Repository record

  10. The regulation of the COL5A1 gene via the 3' - UTR and its impact on Achilles Tendinopathy and other exercise-related phenotypes Yoonus Abrahams.

    Abrahams, YoonusDepartment of Molecular and Cell Biology2013

    Includes abstract. Includes bibliographical references.

    cape-town Repository record

  11. Investigating the importance of the Zika virus 3′ untranslated region to viral fitness

    Storrie, SkyeUniversity of Cambridge2021

    … the Zika virus (ZIKV) 3′ untranslated region (3′UTR) and enhance viral replication. MSI1 is present in high levels in neural progenitor cells of the foetal brain, and previous work proposed that MSI1 could drive the pathogenesis caused by ZIKV, and therefore, could be linked to the cases of …

    cambridge Repository record

  12. Proteins and instability elements involved in phosphoenolpyruvate carboxykinase mRNA turnover

    Hajarnis, Sachin Shrikant, author, Curthoys, Norman, advisor, Bamburg, James, committee member, Mykles, Donald, committee member, Laybourn, Paul, committee member, Wilusz, Jeffrey, committee memberColorado State University. Libraries2006

    … mRNA. Preliminary studies indicated that the 3'-UTR of the PEPCK mRNA binds to proteins from rat renal cortical cytoplasmic extracts. RNA binding proteins can modulate the levels of mRNAs by either stabilizing or targeting the mRNAs for decay. In this three-part study, we have identified the …

    colostate Repository record

  13. Mechanism of mRNA localisation and posttranscriptional modification in Drosophila melanogaster embryonic neurons

    Mofatteh, MohammadUniversity of Cambridge2018

    … localisation and the generation of different 3’UTR isoforms by alternative polyadenylation (APA). While experiments in mammalian systems indicate that subcellular mRNA localisation plays an important role in regulating local expression of proteins in neuronal processes, little is known about how …

    cambridge Repository record

  14. Modulation of microRNA Functions by the 3’ Untranslated Regions of CD44 and Tumour Suppressor Candidate 2

    Jeyapalan, Zina2012

    … The non-coding 3’ untranslated region (3’UTR) plays a significant role in the regulation of microRNA (miRNA) functions. The 3’UTR is hypothesized to function in the feed-back regulation of miRNA functions, since it can bind and inactivate multiple miRNAs. In this study, the effects of the …

    toronto-retro Repository record

  15. Zur Transkriptions- und Translationskontrolle des Gens für Transitionsprotein

    Topaloglu, Özlem2012

    … mice. Earlier results revealed that a 565 bp 5"UTR can direct tissue- and ime-specific expression of Tnp2 gene in transgenic mice. The region was shortened to 147 bp and transgenic mice carrying this construct was generated. To investigate the role of 3" UTR in the translational repression of …

    goettingen Repository record

  16. Investigating The Impact of Intragenic Dna Methylation On Gene Expression, and The Clinical Implications On Tumor Cells and Associated Stroma

    McGuire, Michael, <p>0000-0003-2699-8430</p>2018

    … DNA methylation sites within the gene body and 3’UTR in which DNA methylation is strongly positively correlated with gene expression. We examined 32 tumor types and identified 57 tumor suppressors and oncogenes out of 224 genes containing a correlation of > 0.5 between gene body methylation and …

    uthsc Repository record

  17. Investigations of cellular stress-responsive proteins and PGF gene expression in human trophoblast

    Leavenworth, Jonathan Dean2011

    … in normal vs. stressed conditions, and the PGF 3'UTR was analyzed for consensus 3'AREs. To characterize stability regulation, the PGF 3'UTR was cloned into a reporter construct. To investigate the association between PGF mRNA and RNA binding proteins, an RNA-Immunoprecipitation assay was performed …

    siu-theses Repository record

  18. Sindbis virus usurps the cellular HUR protein to stabilize its transcripts and promote infections of mammalian and mosquito cells

    Sokoloski, Kevin J., author, Wilusz, Jeffrey, advisor, Wilusz, Carol, advisor, Blair, Carol, committee member, Peersen, Olve, committee member, Quackenbush, Sandra, committee memberColorado State University. Libraries2010

    … present in their 3’ untranslated regions (UTR), we hypothesized that these viral 3’UTR elements were functioning similarly to cellular mRNA stability elements resulting in the enhancement of viral infection. The primary goal of the research described in this dissertation was to characterize …

    colostate Repository record

  19. Apobec-1 Complementation Factor (ACF) Binds and Regulates Multiple RNAs

    Delaney, Kimberly2010

    … ARE) are cis-acting RNA sequences in the 3'UTRs of a wide range of transcripts that function to regulate mRNA stability, localization, and/or translation through interaction with ARE-Binding Proteins. Apobec-1 Complementation Factor: ACF) was originally identified as a co-factor in ApoB mRNA …

    wustl Repository record

  20. ZFP36 proteins and mRNA targets in B cell malignancies

    Alcaraz, A.University of Westminster2015

    … rich elements (AREs) in 3’ untranslated (3’UTR) regions of mRNAs. The members of the human family, ZFP36L1, ZFP36L2 and ZFP36 are able to degrade mRNAs of important cell regulators that include cytokines, cell signalling proteins and transcriptional factors. This project investigated two …

    westminster Repository record

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