Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 65 for “"3' Untranslated Region"”.
-
Regulating transcript fate through RNA elements in the 3' untranslated region
… and sequences located primarily in the 3' untranslated region (3'UTR), termed RNA motifs or RNA elements. A common mechanism of post-transcriptional control is guided by small non-coding RNAs (sncRNAs) such as microRNA or piRNA, where proteins are guided to their target transcripts via …
-
Regulation of Salmonella pathogenicity island I through the hilD mRNA 3' untranslated region
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
-
Investigating the importance of the Zika virus 3′ untranslated region to viral fitness
… been shown to bind to the Zika virus (ZIKV) 3′ untranslated region (3′UTR) and enhance viral replication. MSI1 is present in high levels in neural progenitor cells of the foetal brain, and previous work proposed that MSI1 could drive the pathogenesis caused by ZIKV, and therefore, could be …
-
Isolation of novel ABF-1 splice forms
… five clones harboring changes within the coding region of the reported full-length ABF-1 eDNA. In some cases, these changes resulted in the elimination of the coding region specifying the bHLH domain and likely affect DNAbinding and dirnerization of ABF-1. For the other retrieved splice products, …
-
Investigation of selected collagen genes in exercise-related musculoskeletal soft tissue phenotypes
… variants within the functional COL5A1 3’- untranslated region (UTR) have previously been associated with (1) chronic Achilles tendinopathy, (2) Anterior Cruciate Ligament (ACL) ruptures in females, (3) endurance running performance and (4) range of motion (ROM). Since this gene encodes for …
-
Isolation and Characterization of a Full Length Retrotransposon: CR1
… Goose using probes complimentary to the flanking regions of the element. The findings unveiled sequences with a complete ORF1, ORF2, 3' untranslated region and a portion of the 5' untranslated region. This study gets one step closer a further understanding the transposition mechanism that are …
-
Characterisation of the 3'-UTR of the COL5A1 gene: implication for musculoskeletal soft tissue injuries
… A polymorphism (rs12722, C/T) within the 3'-untranslated region (UTR) of COL5A1 is associated with chronic Achilles tendinopathy (TEN) and other soft tissue injuries as well as exercise-related phenotypes. These phenotypes are directly or indirectly associated with the mechanical properties …
-
Modulation of microRNA Functions by the 3’ Untranslated Regions of CD44 and Tumour Suppressor Candidate 2
Recently, the importance of non-coding regions of the genome, which were once presumed to be “junk” DNA, has been revealed. The non-coding 3’ untranslated region (3’UTR) plays a significant role in the regulation of microRNA (miRNA) functions. The 3’UTR is hypothesized to function in the feed-back …
-
IDENTIFYING THE GENETIC MECHANISMS IN SEIZURE THRESHOLD REGULATION
… (NMDAR) activity in cortical neurons. The 3’ untranslated region (3’UTR) of PTGS2 gene was found to be a key site of post-transcriptional regulation by NMDAR activity. However, deletion of T-cell intracellular antigen-1 (TIA-1), an RNA binding protein of COX-2 mRNA 3’UTR, did not affect COX-2 …
-
A data science approach to pattern discovery in complex structures with applications in bioinformatics
… DiscoverR can also be extended to find repeated regions in an RNA secondary structure. Specifically, this extended method is used to detect structural repeats in the 3'-untranslated region of a protein kinase gene.
-
The mechanism(s) of post-transcriptional regulation of the human constitutive endothelial nitric oxide synthase gene by tumor necrosis factor-alpha
… involving proteins that bind to the 3 ' untranslated region of the eNOS message.
-
Mechanisms of Translational Control
… achieved through a complex involving the mRNA 3′ untranslated region (UTR) Sec insertion sequence (SECIS), SECIS-binding protein 2 (SBP2), the 40S ribosomal subunit, and tRNASec bound to eukaryotic elongation factor selenocysteine (eEFSec). Our results reveal a mechanism of Sec UGA recoding in …
-
Structural Basis For Poliovirus Cloverleaf-Mediated Regulation Of Genome Replication
… mediated by a series of six stem-loops in the 3’ untranslated region of the genomic RNA. Stem-loops II-VI comprise an internal ribosomal entry sequence (IRES), which makes cap-independent translation possible. Stem-loop I, also known as the cloverleaf, serves as a switch to shut off translation, …
-
Mir-484 Functions As An Onco-Mir In Triple Negative Breast Cancer
… that miR-484 directly binds to the 3¢-untranslated region (3¢-UTR) of <em>HOXA5 </em>mRNA to suppress its expression. Moreover, HOXA5 over-expression recapitulated the effects of miR-484 inhibition. <em>In vivo</em> therapeutic targeting of miR-484 by systemic administration of …
-
The Interaction Between Eukaryotic Translation Initiation Factor eIF4G and 3’ Cap Independent Translation Element of Barley Yellow Dwarf Virus Is Affected by Multiple Initiation Factors
… independent translation element (CITE) in the 3’ untranslated region of the viral mRNA. BTE (Barley Yellow Dwarf Virus like cap-independent translation element) is one of the well characterized CITEs. BTE mediated translation primarily depends on eukaryotic initiation factor eIF4G. BTE binds to …
-
Identification of Cell Signaling Pathway Regulated By Micrornas In Cancer Cells Using A Systems Biological Approach
… binding of the miRNA to specific sites in the 3' untranslated region of the mRNAs. Because prediction of miRNA targets is an essential step for understanding the functional roles of miRNAs, many computational approaches have been developed to identify miRNA targets. However, identifying targets …
-
Deciphering the mechanism of Transferrin Receptor mRNA degradation under iron replete conditions
… bind to specific sequence elements within the 3’ untranslated region (3’UTR) of the TFRC-1 mRNA and prevent its degradation. Whereas under iron replete conditions there is minimal binding between the IRPs and TFRC-1 mRNA, resulting in TFRC-1 mRNA degradation, the precise mechanism of which is yet …
-
Regulation of Immunoglobulin Gene Diversification By Noncoding RNA's
… CSR, and targets a conserved site in the 3' untranslated region of the AID mRNA. Disruption of this target site in vivo results in quantitative and temporal deregulation of AID expression, accompanied by functional consequences for CSR and affinity maturation. Thus, miR-155, which is known to …
-
Identification of substrate-selective histone deacetylases and their inhibitors that mediate HER2 transcript stability
… to speculation that protein(s) binding the 3’-untranslated region (UTR) of HER2 mRNA become acetylated following HDAC inhibitor treatment and promote the HER2 mRNA decay while engaged in the translational machinery. Pursuing this speculation, a key ribosome- or polyribosome-associated candidate …
-
NMR Studies of the RNA Binding Domain of U1A protein and its Complexes with RNA
… also binds two internal bulges found in the 3' untranslated region of the mRNA which encodes the U1A protein. This is a negative feedback mechanism for regulating its own expression. The RNA binding domain of U1A is contained within residues 2-102 of U1A, and it includes a RNP domain - a domain …
Page 1 of 4