Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"2i"”.
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Disorder and diffuse scattering in single-chirality (TaSe4)2I crystals
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-12-01
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Quantum Codes, Transversal Gates, and Representation Theory
… that shows the binary icosahedral group2I together with a T-like gate forms the most efficient single-qubit universal gate set [54]. To carry out the algorithm fault tolerantly requires a code that implements 2I transversally. We fill this void by constructing a family of distance d = 3 …
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Instructing naïve pluripotency ; JAK/STAT3 and Nanog in reprogramming
… condition using inhibitors for MEK/ERK and GSK3 (2i) fails to occur. This led to the assumption that acquisition of pluripotency in reprogramming is dependent on Nanog. This observation however, had not been verified extensively in alternative culture conditions. Using neural stem cells as a …
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Sistemas alagados construídos de escoamento horizontal subsuperficial com inversão no sentido de escoamento
… invertidos foram denominados SACs- EHSS 1I, 2I e 3I. A título de comparação, determinou-se Ks em um SAC preenchido com brita, denominado SAC-EHSS 0. Ao fim do período experimental, foram retiradas amostras do leito dos SACs-EHSS com o objetivo de quantificar e caracterizar os sólidos …
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THE ROLE OF DNA REPAIR IN DNA METHYLATION DYNAMICS
… serum ESCs and a dynamic system – serum to 2i (naïve) to epiblast-like ES cells. As the role of both AID and UNG involves genomic uracil, the central theme of my thesis is the impact of accumulation of uracil on DNA methylation levels in the genome. Therefore, my first aim was to develop a …
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Toxicological and Pharmacological Studies on Amide Derivatives of 5-Methoxymethyl-2'-Deoxycytidine
… activity of amide derivatives of 5-Methoxymethy1-2i-deoxycytidine (MMdCyd), namely, acetyl-MMdCyd, propanoyl-MMdCyd, butanoyl-MMdCyd and hexanoyl-MMdCyd against Herpes simplex virus type 1 (HSV-l), in A 549 cells and VERO cells was determined using the plaque reduction assay. The potency of MMdCyd …
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Laser-coupled scanning tunneling microscopy and spectroscopy of quantum materials and qubit defects
… the charge density wave (CDW) insulator (TaSe4)2I. In this sample, we show the first reported example of massive-to-massless parametric amplification of a collective sliding CDW phason mode. In this mechanism, the massive 0.22 THz phason yields two massless phasons at half frequency and with …
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Microfluidics and live imaging advances: applications in host/pathogen, immunity and stem cell single cell phenotyping
… time between divisions of mES cells cultured in 2i +LIF and serum + LIF media, and also small but significant differences in durations of sub-cell cycle phases (G1,G1/S,S/G2/M) between the two media conditions. We further applied this imaging setup to study the behaviors of differentiating mES …
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Synthesis and reactions of antimony allyloxides
… a metathesis reaction between SbMe3I2 and SbMe 2I and the sodium salt of the desired alcohol (∼35--60% yields). Compounds of the formula SbMe3(OR)2 (where OR = 3-Methyl-3-buten-2-oxide and 2,6-diisopropyl phenoxide compounds) were synthesized by a metathesis reaction between SbMe3I2 and the …
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Side chain interactions at the dimer interface of Vibrio alkaline phosphatase determine its reactivity, stability and desthiobiotin inhibition
… the enzyme is completely denatured, N2 → I2 → 2I → 2D. This study also assessed a possible inhibition of desthiobiotin (DDB) on VAP. DDB is used to elute purified enzyme samples of Strep-Tactin® affinity columns. Recently, crystal images of VAP in a solution containing DDB revealed some kind of …
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Binäre und Ternäre Verbindungen der Platinmetalle Palladium und Rhodium mit Tellur und Halogenen. Präparationen und strukturelle Charakterisierung.
… und I2 in HI <br>synthetisiert. Im triklinen PdTe2I6 wird PdII zentrosymmetrisch -transplanar <br>von 2I- und 2 TeI2-Liganden koordiniert.In PdTeI2 sind planare Pd(I(TeI))2-Einheiten <br>über Kanten zu Ketten verbunden, die kovalente [TeI]-Einheit hat die Ladung -1. <br>Impedanzspektroskopie an …
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Contribution of Lsh to DNA methylation reprogramming in embryonic stem cell, epiblast stem cell and embryoid body model systems
… stages of mouse embryonic development. The ‘2i’ culture system using two small molecule kinase inhibitors was harnessed to convert lsh-/- mouse embryonic stem cells (mESCs) to a hypomethylated ‘ground state’ of pluripotency. Culture conditions were then altered to transition these ground …
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Cell-to-cell variability and culture conditions during self-renewal reversibly affect subsequent differentiation of mouse embryonic stem cells
… culture or small molecule dual inhibition (2i) of mitogen-activated protein kinase and glycogen synthase kinase reversibly affected levels of Oct4 expression in cells that were otherwise pluripotent. Effects of different self-renewal conditions immediately preceding differentiation are …
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Mechanisms of Methoxide Ion Substitution and Acid- Catalyzed Z/E Isomerization of N-Methoxyimines
… p-Cl (1f, 2f), p-H (1e, 2e), (3,5)-bis-CF3 (1i, 2i)] in 90:10 DMSO:MeOH have been measured. A Hammett plot of these rate constants vs σ values gave positive ρ values of 2.95 (Z isomer) and 3.29 (E isomer). Comparison of these rates with methoxide substitution rates for Omethylbenzohydroximoyl …
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Investigation of the use of extracellular vesicles for the treatment of congenital muscular dystrophy
… mild adult-onset Limb-girdle Muscular Dystrophy 2I (LGMD2I). No effective treatment is currently available for these patients. Current research focuses on three main strategies, small molecule treatments, gene therapy and cell therapy. This thesis investigates the use of extracellular vesicles …
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Role of small RNAs and chromatin in transposable element silencing during global demethylation
… reprogramming and in a transition from serum to 2i culturing of mouse ESCs.
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Genetic Dissection of the Exit of Pluripotency in Mouse Embryonic Stem cells by CRISPR-based Screening
… stem cells (mESCs) with MEK and GSK3 inhibitors (2i). The transcription network that maintains pluripotency has been extensively studied with the indispensable core factors being Oct4, Sox2 and Nanog, together with other ancillary factors reinforcing the network. However, how this network is …
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Interfacial properties of fluid phases in two dimensions and of three-component surfactant systems
… polyoxyethylene alcohol C$\sb{\rm i}$H$\sb{\rm 2i+1}$(OC$\sb2$H$\sb4$)$\sb{\rm j}$OH. It is found that two systems, water/n-hexadecane/C$\sb6$E$\sb2$ and water/n-octadecane/C$\sb6$E$\sb2$, exhibit a wetting transition lying at least 10$\sp\circ$C below the upper critical temperature, and one …
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Wearing the Wunderkammer: A practice-led analysis of cabinets of curiosities, examining the quality of curiosity and applying it to a fashion exhibition
… cabinets of curiosities as sites of knowledge. 2I have chosen to use the term fashion, rather than dress or another equivalent, throughout this thesis. My reason for this is articulated in a section of the Introduction, ‘Terminology’.
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Protein factors and 5' flanking sequences involved in the expression of the mouse myelin basic protein gene.
… factor 1 (Pit-1) or general transcription factor 2i, the E2F family transcription factor, the PASK protein and two of the clones were identified as c-jun. One clone, however, remains unidentified and this could be a novel transcription factor.
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