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Showing 1 to 4 of 4 for “"2ME2"”.
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Evaluation of the Pharmacokinetic-Pharmacodynamic relationship, Metabolism and Plasma Protein Binding of the novel antitumor agent, 2-Methoxyestradiol (2ME2), following oral administration in patients with solid tumors.
… safety, tolerability and pharmacokinetics of 2ME2 in patients with solid tumors and determine maximum tolerated dose (MTD). The following hypotheses were tested: 1) 2ME2 will be well tolerated in clinic when given orally and will have quantifiable effects on the ex vivo markers of angiogenesis …
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Inhibition of progestin-induced VEGF in mammary cancer by curcumin and 2-methoxy estradiol and their potential role as anti-angiogenic & chemopreventive compounds
… root derivative, and 2-methoxyestradiol (2ME2), a natural metabolite of estradiol, effectively inhibit progestin-induced VEGF secretion from breast cancer cells in vitro. Furthermore, curcumin delays progestin-accelerated DMBA-induced tumorigenesis in Sprague-Dawley rats. 2ME2 inhibits …
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Investigating the Interaction of Chitin in Organic Electrolyte Solutions Using Molecular Dynamics
… ((GlcNAc)2Me2) molecules (chosen as the model for chitin) in various solvent systems using potential of mean force calculations. The ionic liquids of choice were 1-butyl-3-methylimidazolium acetate ([C4C1im][CH3COO]) and 1-butyl3-methylimidazolium methyl …
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Mechanisms of Neonatal Brain Injury in a Rat Pup Hypoxic-Ischemic Model
… a activity was inhibited by 2-methoxyestradiol (2ME2,1.5, 15 or 150 mg/kg) or enhanced by dimethyloxalylglycine (DMOG, 250 mg/kg). 2ME2 treatment exhibited dose-dependent neuroprotection by decreasing infarct volume and reducing brain edema at 48 h post HI. The neuroprotection was lost when 2ME2 …