Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"2G12"”.
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Pilot-scale process development for the purification of the recombinant antibody 2G12 from transgenic tobacco
… of the recombinant anti-HIV antibody 2G12. Different techniques were successfully combined into a process strategy to fulfill this objective. Clinical-grade recombinant antibody was purified using by the following process steps and industrially available equipment: manual harvest, …
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Solution-phase and automated solid-phase synthesis of high-mannose oligosaccharides : application to carbohydrate microarrays and biological studies
(cont.) 2G12, cyanovirin-N, and a recently identified anti-HIV protein, scytovirin.
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Taraxacum officinale as an expression system for recombinant proteins : molecular cloning and functional analysis of the genes encoding the major latex proteins
… by expressing the HIV-specific full length 2G12 antibody. In the present study, we demonstrated the expression and assembly of full-length heavy and light chains to form functional 2G12 antibodies in T. officinale leaves and latex fraction.
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The Ontogeny of Vaccine-Induced HIV-1 Glycan-Reactive Antibodies
… that the rhesus DH717.1 V3-glycan antibody and 2G12, a human V3-glycan bnAb isolated from a HIV-1 infected donor, showed remarkable similarity in accommodation of high-mannose glycans. Specifically, DH717.1 and 2G12 antibodies accommodate terminal branches of high-mannose glycans through the …
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The screening of neutralising antibodies against a resistant HIV-1 strain to identify novel epitopes
… antibodies (mAbs) b12 (anti-CD4-binding site), 2G12 (anti-V3/glycan), 2F5 and 4E10 (both anti-membrane proximal external region). Of note, the virus is resistant to the extremely broad and potent mAb VRC01 (anti-CD4-bs). QH343.A10 was also found to be resistant to neutralisation by soluble CD4 …
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Expression and characterisation of biopharmaceuticals in heterologous expression systems
The production of two complex human proteins, the therapeutically relevant anti-HIV full-size IgG1/kappa antibody, (BY-2)2F5, and a soluble form of the high-affinity receptor for human IgG, Fc-gamma-RI (CD64), were successfully established and optimised for heterologous expression in plants, …