Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 83 for “"2D NMR"”.
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Developments in 2D NMR relaxometry and its application to biological tissue
Abstract In this thesis the capability of 2D NMR relaxometry to distinguish between different biological tissues is established using fresh unpreserved samples of lamb’s liver and kidney. A novel use of 2D T1-T2 relaxation spectra to provide characteristic profiles of specific tissues in specific …
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Extracting Ramachandran torsional angle distributions from 2D NMR data using Tikhonov regularization /
Solid state nuclear magnetic resonance (NMR) spectroscopy is a powerful technique for studying structural and dynamical properties of disordered and partially ordered materials, such as glasses, polymers, liquid crystals, and biological materials. In particular, twodimensional( 2D) NMR methods such …
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Investigating C. Elegans Small-Molecule Signaling Pathways Via 2D-Nmr Based Comparative Metabolomics
… will be discussed which is heavily based on 2D-NMR Spectroscopy but often requires LC/MS validation. Using this technique, two main small-molecule metabolic pathways have been investigated in the purview of this thesis using the model organism C. elegans. The first one, the steroid biogenesis …
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Isolation and Structural Elucidation of Compounds from Natural Products
… were done using mass spectrometry, 1D and 2D NMR spectroscopy techniques. A systematic study of the ethanol extract of the plant Neoharmsia baronii Drake from the Madagascar forest led to the isolation of seven compounds, characterized as isoflavones and pterocarpans. The structures of the …
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Isolation and Structure Elucidation of Antiproliferative Agents From Madagascar Rainforests
… carried out using mass spectrometry and 1D and 2D NMR techniques. The bioassay-guided fractionation of Roupellina (Strophanthus) boivinii yielded three new and one known cardenolide glycosides. The structure of the known cardenolide glycoside was determined after comparison of NMR data to that …
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NMR Relaxometry and Diffusometry Studies for Investigating Heterogeneous Catalysis
… implementation of nuclear magnetic resonance (NMR) methods to provide quantitative information on chemical conversion within a novel NMR compatible trickle-bed reactor (TBR). Techniques to map the distribution of chemical species within a catalyst bed were implemented under non-steady state and …
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Part I. Metabolites From the Pohnpei Sponge Stylissa Massa. Part II. Identification of Illudin S as the Sole Antiviral Compound in the Fruiting Bodies of Omphalotus Illudens. Part III. Structure Elucidation of Oscillacidins a and B From a Homer Lake Oscillatoria Sp
… and Aound were isolated, in addition to 2D NMR work and partial acid hydrolysis performed on the whole molecule.
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Chemical and biological evaluation of palythoa tuberculosa collected from the red sea
… were elucidated on the basis of their 1D and 2D NMR and MS spectroscopic data. Palysterols B and G demonstrated cytotoxic activity on three human cancer cell lines (MCF-7, HeLa, and HT- 29). Palysterol G, in particular, was able to induce apoptosis in breast adenocarcinoma(MCF-7) cells
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Isolierung und Identifizierung von Sexualpheromonen des marinen Polychaeten Platynereis dumerilii (Annelida, Polychaeta)
… inaktive Abbauprodukt wurde mit UV-, 1D-, 2D-NMR und ESI-MS-Experimenten als L-Ovothiol A disulfid identifiziert. L-Ovothiol A stellte das ERP dar, aus dem das Disulfid durch Oxidation entstand. Das isolierte Pheromon und synthetisches rac-Ovothiol A zeigten identisches Verhalten auf …
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Isolation, structure elucidation and approaches to the partial synthesis of new taxol analogs
… by spectral methods, including extensive 2D nmr techniques. An approach to the synthesis of a novel A-nortaxol analog from one of the new compounds has been developed.
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Spektroskopische Strukturanalytik synthetischer Polypeptide
… Strukturanalysen mit Hilfe der CD-, Raman- und 2D NMR-Experimente an zwei Serien von Polypeptiden lieferten Aussagen über die Sekundärstruktur. Insbesondere die Raman-Untersuchungen in Verbindung mit einer statistischen Datenanalyse lieferten detaillierte Information über subtile …
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Discovery, Isolation, and Identification of Antimalarials from Fungal Endophytes
… using <super>1</super>H- and <super>13</super>C-NMR. 2D-NMR and LC-MS analyses helped confirm that our endophytes were indeed producing artemisinin. Growth versus production studies were conducted to optimize our growth and extraction conditions while several other variables, like temperature and …
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NMR characterisation of group b streptococcus capsular polysaccharide repeating units
… pneumoniae. Nuclear magnetic resonance (NMR) spectroscopy has been established as an extremely useful and robust method for tracking the manufacturing process of carbohydrate vaccines from polysaccharide antigen through to conjugate vaccines. The 1D proton profiles of most of the GBS …
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Darstellung und Charakterisierung neuartiger C-Arylcalix(4)resorcinarene
… die Methoden zur Strukturaufklärung mittels 2D-NMR-Spektroskopie bei diesen Verbindungen vor. Möglichkeiten zur Unterscheidung des rccc-Isomer vom rctt-Isomer werden beschrieben. Das Kapitel 5 zeigt wesentliche Ergebnisse der semiempirischen Rechnungen zu C-Arylcalix(4)resorcinarenen und …
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Reactivity studies of arene-cis-diols in cycloadditions and potassium permanganate oxidations: synthesis of the corresponding arene-trans-diols and an approach to the synthesis of (+)-pancratistatin
… cycloadducts were elucidated by nOe as well as 2D-NMR analysis and were supported by Frontier Molecular Orbital theory. Finally, arene-trans-diols (200) were synthesized from (7) by a multistep stereoselective protection/deprotection sequence utilizing the Diels-Alder reaction. These compounds …
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Aspects of the chemistry of 1,4-naphthoquinones. An investigation of nucleophilic substitution reactions of alkylamines and hydroxyalyklamines on 1,4 napthoquinones and the role of solvent on the position of substitution.
… structures of which were confirmed via 1D and 2D NMR spectroscopy, mass spectrometry (ESI), IR spectroscopy and high resolution mass spectrometry (HRESIMS and HREIMS).
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Thermal unfolding dynamics of proteins probed by nonlinear infrared spectroscopy
… IR techniques, two-dimensional infrared (2D IR) spectroscopy, which is an IR analogue of 2D NMR, is the most informative. A 2D IR spectrum is obtained from a double Fourier transform of the heterodyned third-order nonlinear signal, which is generated by three consecutive interactions …
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Discovery and Delivery of Bioactive Natural Products
… by analysis of their mass spectrometric, 1D and 2D NMR, and ECD spectrum. Among these natural products, there were three compounds with good antiplasmodial activity, trichospirolide A with an IC50 value of 1.5 μM, malleastrumolide A with an IC50 value of 2.7 μM, and (+)-lariciresinol with an IC50 …
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Solid-State NMR Characterization of a PET Ligand Binding Sites in AD Tau Fibrils
… adopts the C-shaped AD fold. Using solid state NMR experiments in combination with other techniques such as Transmission Electron microscopy (TEM) as well as docking simulations allowed a better understanding of the binding sites of this PET agent. Specifically, 13C-19F REDOR experiments were …
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Antiproliferative Natural Products from the Madagascar Rainforest
… were determined using a combination of 1D and 2D NMR experiments, including COSY, HSQC/HMQC, HMBC, and ROESY/NOESY sequences, mass spectrometry, and chemical conversion. In addition, ten known compounds were obtained from five of the extracts. Studies on the remaining extracts were suspended …
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