Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"27-hydroxycholesterol"”.
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Mechanisms by which 27-hydroxycholesterol modulates the secretion of extracellular vesicles
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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27-Hydroxycholesterol promotes breast cancer progression through the modulation of myeloid cells
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-12-01
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Oxysterols in Neurodegeneration and the Influence of Presynaptic α-Synuclein Phosphorylation
… derivatives known as oxysterols. Notably, 24S-hydroxycholesterol (24S-HC) and 27-hydroxycholesterol (27-HC) have been implicated in exacerbating neurodegenerative processes by modulating protein aggregation and increasing cellular vulnerability. However, the precise molecular and cellular …
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A machine learning approach to spike sorting to reveal neuronal signalling defects in models of neurodegeneration
… The results indicate that treatments involving 27-hydroxycholesterol in the presence or absence of α-synuclein lead to significant neuronal defects, including reduced electrical and calcium activity and synchronisation. The developed machine learning-based spike sorting methods represent …
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Oxysterol Signature as Putative Biomarker in Niemann-Pick Type C and Inflammatory Bowel Diseases
… processes. For example it was found that 25-hydroxycholesterol (25-OHC) possesses anti-viral functions. This illustrates that the physiological importance of oxysterols was underestimated and that their implications are still not completely unravelled. Oxysterol analysis, however, is tricky …
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ROLE OF HIGH DENSITY LIPOPROTEINS AGAINST PROSTATE CANCER
… exert antiproliferative effects. However, 27-hydroxycholesterol (27-HC) has been shown to promote tumor growth in breast cancer, although its role in PCa remains controversial. Several studies report an inverse correlation between HDL-cholesterol levels and cancer prognosis, including in …