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Showing 1 to 14 of 14 for “"25 dihydroxyvitamin D3"”.
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Model-Guided Transdermal Formulation of 1α,25-Dihydroxyvitamin D3 for Improved Safety and Efficacy
1α,25-Dihydroxyvitamin D3 [1,25(OH)2D3], the active ligand of vitamin D receptor (VDR), is useful for the prevention and treatment of various diseases, including chronic kidney disease (CKD), cardiovascular disease, hypercholesterolemia and neurodegenerative diseases. However, the therapeutic …
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Regulation of Human Osteosarcoma Cell Differentiation by Transforming Growth Factor B1 (TGFB and 1a,25- Dihydroxyvitamin D3 : the Mechanism of TGFB1 Potentiation of 1,25D3-induced Alkaline Phosphatase Activity in Human MG63 Osteosarcoma Cell
… that the combination of TGFβ<sub>1</sub> and 1α,25-dihydroxyvitamin D<sub>3</sub> had a synergistic effect on alkaline phosphatase induction (500 to 700%) in human osteoblastic osteosarcoma cells (MG63). The current studies focused on the molecular basis of alkaline phosphatase induction, …
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Synthesis of 20S-Hydroxyvitamin D3 Analogs and Their 1α-Hydroxyl Derivatives as Potent Anti-inflammatory Agents
… in total. Among the treatment options of RA, 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3] is the only steroidal drug used clinically for anti-inflammatory and immune diseases. However, long-term use of 1,25(OH)2D3 (625 µg/day) in human would result in hypercalcemia (toxicity), and 1,25(OH)2D3 has …
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Intestinal absorption barriers as modelled by p-glycoprotein and cytochrome p450 a34 in caco2 cells
… of non-exposed cells. Exposing Caco-2 cells to 0.25 JAM la, 25-dihydroxyvitamin D3 induces their expression of cytochrome P450 3A4 protein to the level that is equivalent to that from isolated human jejunal cells. Under the same treatment, doxorubiein-exposed (Type I) cells metabolise naidazolam …
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Identifying Context-Specific Synthetic Lethal miRNA Inhibition in Non-Small Cell Lung Cancer
… cell lines mimicked activation of a 1α, 25-dihydroxyvitamin D3 response in NSCLC cell lines in a manner consistent with sensitivity to the miR-92a inhibitor. The results of this investigation demonstrate that the screening approach utilized in this study was capable of identifying a …
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The Role of Vitamin D in Skeletal Muscle Function and Regeneration
… hydroxylases required to convert Vitamin D to 25[OH]D and subsequently the bioactive 1α-25-dihydroxyvitamin D3 (1α-25[OH]2D3) (Girgis et al., 2014b). Crucially, the Vitamin D receptor (VDR) is also present in skeletal muscle (Srikuea, Zhang, Park-Sarge, & Esser, 2012) and upon exposure, binds …
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Immunogenetic Study of Autoimmunity-Associated Variants in Selected TNF Superfamily Genes
… of cultured monocytes with Vitamin D (1α,25-Dihydroxyvitamin D3) results in upregulation of TNFSF14 gene expression. Moreover, I present preliminary data to show that treatment of cultured monocytes and MDMs with recombinant human LIGHT resulted in upregulation of immunoregulatory markers. …
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Expression und Regulation 1,25(OH) 2 -Vitamin D 3-responsiver Gene in monozytären Zellen
Das Secosterid Vitamin D3 wird durch die Nahrung aufgenommen oder im Organismus synthetisiert, wobei eine Reaktion in der Haut durch einen photochemischen Prozess katalysiert wird.Durch zwei Hydroxylierungsschritte in Leber und Niere wird Vitamin D3 über 25(OH) Vitamin D3 zum aktiven 1,25(OH)2 …
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The roles of vitamin D in cutaneous wound healing: In vitro and ex vivo studies of the effect of 1,25(OH)2D3 and its precursors on human dermal fibroblasts and epidermal keratinocytes in cutaneous wound healing
… is the main site for the synthesis of Vitamin D3 (cholecalciferol) from 7-dehydrocholesterol. Cholecalciferol undergoes further hydroxylation in the liver and kidney to produce the active form of the circulating hormone 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3). In target cells, 1,25(OH)2D3 …
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“Differential regulation of PTHrP gene expression by 1,25(OH)2D3 in prostate cancer cell lines”
… to control PTHrP expression in these cells. 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) downregulates PTHrP expression in a variety of human cell types, including prostate cancer cells. Therefore, downregulation of PTHrP gene expression by 1,25(OH)2D3 may enhance the therapeutic benefits of …
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Producción de Intermediarios Reactivos de Nitrógeno en cultivo de células mononucleares de cabras expuestas al BCG de M. bovis, suplementadas con 1,25 Dihidroxivitamina D3
… que el principio activo de la vitamina D, la 1,25 Dihidroxivitamina D3 [1,25(OH)2D3] ha resultado ser un potente regulador de la respuesta inmune. El objetivo de este estudio fue evaluar el efecto de la 1,25(OH)2D3 sobre la inducción en la síntesis de Intermediarios reactivos de nitrógeno (RNI) …