Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"22Rv1"”.
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Investigation of the Anti-Proliferative and Pro-Apoptotic Effects of Rosemary (Rosmarinus officinalis) Extract on Androgen Independent Prostate Cancer Cells
… extract (RE) on prostate cancer cells. PC-3 and 22Rv1 prostate cancer cells, representative in vitro models of androgen independent prostate cancer, as well as the PNT1A non-cancerous prostate epithelial cells were treated with RE and docetaxel (established prostate cancer chemotherapeutic drug) …
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Role of Wnt5a in Prostate Cancer
… Wnt5a treatment decreased invasion in 22Rv1 and DU145 cells while Wnt5a knockdown resulted in increase in invasion in LNCaP and 22Rv1 cells. In the light of conflicting reports on the role of Wnt5a in prostate cancer outcome, we validated our findings in an external population-based …
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Germline HOXB13 G84E Mutation Inhibits MEIS1-HOXB13 Driven Tumor Suppression in Prostate Cancer
… resulted in faster onset and progression of 22Rv1 tumor xenografts in SCID mice and were confirmed to have a significant reduction in the proteoglycans, Decorin and Lumican. Exogenous addition of Decorin and Lumican reduced growth and migration of PrCa cell lines. These data support the …
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Drug Discovery in Redox Biology: From Natural Products to Structural Biology
… stem bark extracts against prostate cancer (22Rv1) cells. Sequential chromatographic fractionation followed by semi-preparative HPLC purification yielded six compounds identified by spectroscopic analysis as vanillin, propylene glycol, β hydroxypropiovanillone, …
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Small molecule inhibitors of steroid receptors for breast and prostate cancer
… and androgen-independent proliferation of 22Rv1 cells, a model for castration-recurrent prostate cancer. These novel small molecule inhibitors represent important new probes for understanding AR action. In addition, CPIC and its structural analogues have properties that make them suitable …
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Discovery of Inhibitors of Inhibitors of Apoptosis Proteins and Novel Tubulin Polymerization Inhibitors as Potential Anticancer Agents
… and 5.3 μM against EU-1, A375, MDA-MB-231, and 22Rv1 cell lines, respectively. Analog 3e decreased MDM2 and XIAP protein levels while simultaneously promoting p53 expression. Compared to AMG-232, a potent MDM2-p53 inhibitor in clinical trials, 3e showed potency in the p53-mutant MDA-MB-231 cell …