Global ETD Search
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Showing 1 to 4 of 4 for “"2-thiouridine"”.
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Biosynthesis and Functions of tRNA 2-Thiouridine in Bacillus subtilis
… thiamine, biotin and thionucleosides, such as 2-thiouridine. Thiolation of the wobble uridine on tRNA molecules to yield 2-thiouridine is critical for accuracy and efficiency in translation in all three domains of life, and depletion of this thionucleoside is associated with severe growth …
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Characterization of two novel proteins containing the rhodanese homology domain: YgaP and YbbB of Escherichia coli
… affect the production of 5-methylaminomethyl-2-thiouridine (mnm5s2U), the precursor to mnm5se2U, suggesting that YbbB is not required for sulfur transfer but is rather involved in selenation of tRNAs. YbbB was subsequently expressed with a C-terminal histidine tag and purified for initial …
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Synthesis and biological evaluation of purine and pyrimidine based ligands for the A3 and P2Y2 purinergic receptors
… P2Y2 receptor agonist 2’-amino-2’-deoxy-2-thiouridine 5’-triphosphate (4.2, EC50 (P2Y2) = 8 nM) (chapter 4). UTP and its diverse synthesized analogues are sensitive to enzymatic degradation. Replacement of the -phosphate group by an isosteric phosphonomethyl group should enhance the …
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Versuche zur Strukturaufklärung bakterieller Thiouridin Synthetasen
Von nahezu allen rezenten Organismen ist bekannt, dass ihre tRNA posttrans-kriptional modifiziert wird. Ein Beispiel für diese Modifikationen ist die Insertion von Schwefel, wie sie durch die beiden Sulfurtransferasen ThiI und MnmA katalysiert wird. ThiI katalysiert die Insertion von Schwefel an …