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Showing 1 to 4 of 4 for “"2-pyridones"”.
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The arylation of 2-pyrones and related heterocycles
2-Pyrones, and related heterocycles such as 2-pyridones, 2-coumarins and 2- quinolones, are useful model substrates to test a novel methodology due to their varied chemical properties. In addition, these moieties possess broad spectrum biological activity. Chapter 1 provides a review of C–H …
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THREE STUDIES OF 2-PYRIDONE PHOTOADDUCT REACTIVITY
2-Pyridones such as iii undergo efficient [4+4] photocycloaddition reactions, yielding strained tricyclic cyclooctadiene structures iv and v, with functionality at every carbon. As part of a program to develop the chemistry of these complex adducts, three studies have been conducted. Halogenation …
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Light-Mediated Dual Catalysis for C–N Bond Formation
… substituted and conformationally stable N-aryl-2-pyridones is described. This motif has emerged as a privileged scaffold in medicinal chemistry with applications in immunology and oncology, evidenced by the recent FDA approval of KRAS inhibitor sotorasib.4 This work describes the design of a …
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PHOTOCHEMICAL AND TITANIUM (II) MEDIATED METHODS FOR THE SYNTHESIS OF COMPLEX MOLECULAR SCAFFOLDS
… Intramolecular [4 + 4] photoreaction of 2-pyridones with silyl 3-enol-1-ynes yields a highly reactive 1,2,5-cyclooctatriene. In the presence of a silanol proton source the allene is converted into a 1,3-diene. Without the combination of silyl 3-enol-1-ynes and silanol, as previously …