Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"2-deoxy-glucose"”.
-
Exploring the effects of insulin and glucose on the development of in vitro produced domestic cat embryos
It is possible to evaluate the effects of glucose and insulin on feline embryonic development using in vitro fertilization and embryo culture. The objective of this study was to determine if glucose concentrations greater than ≥ 6 mM with or without varying concentrations of insulin would affect …
-
Development of Carbohydrate-based Diblock Polymers for Nucleic Acid Delivery
… were developed to synthesize 2-methacrylamido-2-deoxy glucose and 6-methacrylamido-6-deoxy trehalose starting with commercially available carbohydrates and utilizing trimethylsilyl protecting group chemistry. These monomers were polymerized via reversible addition-fragmentation chain transfer …
-
The impact of glucotoxicity on pancreatic β-cell function
… mellitus is connected with elevated plasma glucose levels which negatively influence β-cells and cause impaired glucose-stimulated insulin secretion (GSIS). The aim of present thesis was to investigate the impact of long-term hyperglycemia on the pancreatic islet β-cell function. The data …
-
Novel Amino Acid Transporter-Targeted Radiotracers For Breast Cancer Imaging
… and diagnosis. <sup>18</sup>F-2-Fluoro-2-deoxy-glucose (<sup>18</sup>F-FDG), using positron emission tomography (PET), is the most common functional imaging tool for breast cancer diagnosis currently. Unfortunately, <sup>18</sup>F-FDG-PET has several limitations such as poorly …
-
Mitotic slippage by ATP depletion and its mechanism
… hand, ATP depletion by the co-treatment with 2-deoxy glucose (2-DG) and sodium azide (NaN3) during interphase caused robust cell cycle arrest, supporting the existence of energy checkpoints sensing shortage of ATP supply before mitosis. On the other hand, reduction of ATP during or after …
-
Sweet relief: regulating the response to glucose phosphate stress by the small RNA SgrS & Co.
Cells use complex mechanisms to regulate glucose transport and metabolism to achieve optimal energy and biomass production while avoiding accumulation of toxic metabolites. Glucose transport and glycolytic metabolism carries the risk of the buildup of phosphosugars, which can inhibit growth at high …
-
REACTIONS AND PROCESSES AT CELL-MIMICKING MEMBRANE SURFACES
… of substrate for enzymatic oxidation of glucose and 2-deoxy-glucose. Three important biological-relevant properties of cellular membrane: transport, bioavailability, and bio-reactivity of enzyme and substrate were studied. We found that enzyme molecules retained their reactivity when …