Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"2-arachidonoylglycerol"”.
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Bioactive Lipids in Nociception
… metabolized to monoacyl-glycerols, such as 2-arachidonoylglycerol (2-AG) and 2-oleoylglycerol by the action of DAG lipase. 2-Arachidonoylglycerol and 1-AG activate both native TRPV1 on sensory nerve fibers in rodent mesenteric arteries and heterologously expressed rat and human TRPV1. The …
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Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation.
… concentration was significantly (2-arachidonoylglycerol / 2-AG) increased in injured artery sections. Isolated vessel studies demonstrated that AEA produces a small (~20%) relaxation of the murine carotid artery which was not dependant on the production of active metabolites, but …
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Effect of Cannabinoids and Stress on Motor Maps and Behaviour
… expression and that both anandamide (AEA) and 2-arachidonoylglycerol (2-AG) contributed to this effect. Activation of CB1R signaling did not affect skilled reaching task performance. However, a lack of cannabinoid signaling resulted in impairment on performing the reaching motion. The second …
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The Role of MAGL Inhibition in Nicotine Withdrawal and Reward
… investigate the role of enhancing endogenous 2-arachidonoylglycerol (2-AG) and by blocking its degradative enzyme, monoacylglycerol lipase (MAGL) enzyme, in nicotine reward and dependence. The selective MAGL inhibitor JZL184 dose-dependently reduced both precipitated and spontaneous somatic and …
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Physical fitness and exercise as modulators of the endocannabinoid system in adults with mild-to-moderate depression the sonrie study
… endogenous ligands are anandamide (AEA) and 2-arachidonoylglycerol (2-AG). These components, along with associated analogues interact with CB1 and CB2 receptors. CB1 receptors are abundant in the central nervous system and implicated in cognitive, emotional, and motor functions, whereas CB2 …
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Studies to determine the mechanisms of the anti-atherosclerotic effects of eicosapentaenoic acid: possible role for endocannabinoids?
… activated macrophages significantly inhibited 2- arachidonoylglycerol (2-AG) synthesis. This finding is strongly suggestive of an association between the effects of ω-3 PUFAs and regulation of the endocannabinoid system and its function. In the ApoE-/- mouse model of experimental atherosclerosis, …
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Sensitivity to chemical stimuli plays a fundamental role in the food preferences. Examples in the evolutionary scale: 1. Role of the walking leg chemoreceptors in the red swamp crayfish Procambarus Clarkii 2. PROP bitter taste sensitivity and its nutritional implications in Humans
… the plasma profile of the endocannabinoids 2-arachidonoylglycerol (2-AG), anandamide (AEA) and congeners in normal-weight PROP super-tasters and non-tasters, also we assessed the cognitive eating behavior disorder by the Three-Factor Eating Questionnaire. The results showed that: 1) Basal …
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Central cannabinoid regulation of food intake in chickens
… endogenous cannabinoid ligands, anandamide and 2-arachidonoylglycerol, were observed in the central nervous system and peripheral tissues. Endocannabinoids differ from other "classical" neurotransmitters because they do not appear to be stored in synaptic vesicles, and they act as retrograde …
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Investigation of chemotherapy-induced peripheral neuropathy-related behaviour in male and female ratsa role for the endocannabinoid system
… Nacylethanolamines showed that PTX increased 2-arachidonoylglycerol, Npalmitoylethanolamide (PEA) and N-oleoylethanolamide levels in the amygdala of both male and female animals. Next, we assessed whether this pain phenotype was sensitive to acute pharmacological modulation of endocannabinoid …
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Cytochrome P450 2J2 mediated metabolism of omega-6 and omega-3 endocannabinoids
Cytochrome P450 2J2 (CYP2J2) is membrane bound enzyme that is highly expressed in the cardiovascular system and brain where it mediates the metabolism of polyunsaturated fatty acids into oxygenated bioactive metabolites. This enzyme is most well-known for the conversion of arachidonic acid into …