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Showing 1 to 3 of 3 for “"2-Chloroacrylonitrile"”.
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Cyanate Formation Following 2-Chloroacrylonitrile Exposure and the Role of Cytochrome P-450
2-Chloroacrylonitrile (2-CAN) is a volatile, toxic chemical used as a raw material to manufacture pesticides. Although the toxic mechanism is not fully understood, the hypothesis in the literature is that 2-CAN may be metabolized to cyanide. An understanding of the mechanism of 2-CAN toxicity will …
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Design and synthesis of ring D modified steroidal hormones
… 14,16-pentaen-17-yl acetate and 2-chloroacrylonitrile underwent an unprecedented tandem rearrangement, on attempted alkaline hydrolysis to the corresponding ketone. This product, obtained in ca. 90% yield, was formulated as …
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Design and synthesis of rotational analogues of estradiol
… the second phase of the work~ cycloaddition of 2-chloroacrylonitrile to the 14,16- diene, followed by alkaline hydrolysis afforded 3-methoxy-14, 17a.-ethenoestra- , 1,3,5(10)-trien-15-one and 3-methoxy-14, l 7a.-ethenoestra-l ,3,5(1 0)-trien-16-one, with the 15-ketone as the major isomer. …