Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"2-AG"”.
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Hämodynamische Auswirkungen synthetischer, pflanzlicher und endogener Cannabinoide im Modell der isolierten Kaninchenlunge
… Anandamid und 2-Arachidonylglycerol (2-AG) dosisabhängig den pulmonalarteriellen Druck erhöhen. Cannabinoide, die abweichend zu Anandamid und 2-AG keine Arachidonsäurestruktur haben, z.B. das synthetische HU-210 oder das pflanzliche Δ9-THC, erhöhen den pulmonalarteriellen Druck nicht. Im …
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Bioactive Lipids in Nociception
… surface receptors. After PLC-dependent cleavage of phosphatidylinositol bisphosphate into diacylglycerol (DAG) and inositoltrisphosphate, diacylglycerol may be further metabolized to monoacyl-glycerols, such as 2-arachidonoylglycerol (2-AG) and 2-oleoylglycerol by the action of DAG lipase. …
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Modulation of Fatty Acid-Induced Skeletal Muscle Inflammation by the Peripheral Endocannabinoid System.
… anandamide (AEA) and 2-arachadinoylglycerol (2-AG) on palmitate-induced NFκB-signalling and gene expression were investigated in L6 rat skeletal muscle cells. The findings reveal that whilst AEA and 2-AG did not induce NFκB signaling they were able to attenuate palmitate’s ability to promote …
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Physical fitness and exercise as modulators of the endocannabinoid system in adults with mild-to-moderate depression the sonrie study
… anandamide (AEA) and 2-arachidonoylglycerol (2-AG). These components, along with associated analogues interact with CB1 and CB2 receptors. CB1 receptors are abundant in the central nervous system and implicated in cognitive, emotional, and motor functions, whereas CB2 receptors are mainly …
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Silver Doped Hydroxyapatite Coating on Titanium Surfaces and its Effect on Early Bone Response and Osseointegration
… to have anti-microbial properties is silver (Ag). However, the effects Ag has on osteoblastic activity as well as decrease bacterial load has yet to be determined.</p> <p>In this study, the effect of Ag-doped HA coatings on initial bacterial adhesion and osteoblast cell proliferation, …
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Effect of Cannabinoids and Stress on Motor Maps and Behaviour
… anandamide (AEA) and 2-arachidonoylglycerol (2-AG) contributed to this effect. Activation of CB1R signaling did not affect skilled reaching task performance. However, a lack of cannabinoid signaling resulted in impairment on performing the reaching motion. The second study characterized acute …
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Cytochrome P450 2J2 mediated metabolism of omega-6 and omega-3 endocannabinoids
… to address the propensity of CYP2J2 to aggregate in solution, each construct was incorporated into the native membrane bilayers of nanodiscs for rigorous spectroscopic and functional studies. Notably, all N-terminal constructs were stably bound within the nanodisc bilayers, which …
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The Role of MAGL Inhibition in Nicotine Withdrawal and Reward
ROLE OF MAGL INHIBITION IN NICOTINE WITHDRAWAL AND REWARD. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. by Pretal Ishvarlal Patel Muldoon Director: M. Imad Damaj, PhD Professor, Department of …
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Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation.
… was significantly (2-arachidonoylglycerol / 2-AG) increased in injured artery sections. Isolated vessel studies demonstrated that AEA produces a small (~20%) relaxation of the murine carotid artery which was not dependant on the production of active metabolites, but involved activation of the …
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Diacylglycerol lipaseα-dependent endocannabinoid signaling in neural stem cells
The diacylglycerol lipases (DAGL α and β) synthesise 2-AG, the major endocannabinoid (eCB) in the developing and adult brain. 2-AG acts most prominently on the CB1 and CB2 receptors and growing evidence points to a role of eCB signaling in adult neurogenesis as well as a wide range of different …
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Silver (I) Complexes as Antimicrobial and Anticancer Drugs
… carboxylates, such as polymeric [Ag2(9-aca)2]n and [Ag2(9-aca)2(DMSO)2]n, and the ammoniacontaining complex, [Ag4(9-aca)4(NH3)2], are provided along with imidazole derivatives, such as [Ag2(9-aca)2(DMSO)2]n and [Ag6(imidH)4(9-aca)6(MeOH)2]. Silver(I) carboxylates containing …
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Alterazioni indotte dall'isolamento sociale sulla regolazione a feedback negativo dell'asse ipotalamo-ipofisi-surrene
… level of CRF and of endocannabinoid 2-AG, hypothalamic endocannabinoid receptors (CB1 receptors) and hippocampal and hypothalamic glucocorticoid receptors (GR), in at different time point after acute heterotypic stress (foot-shock, 5 min). Moreover we have investigated GR function by …
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Compuestos heterometálicos de iones de capa cerrada con ligandos macrocíclicos
… heterometálicos de Au(I)/Cu(I), Au(I)/Ag(I) y Au(I)/Tl(I) frente a ligandos macrocíclicos de diferente naturaleza y capacidad coordinativa ([9]aneS3, [14]aneS4, [24]aneS8, [12]aneS3N-CH2Quinolina y [12]aneS2N2-(CH2Quiniolina)2) da lugar a la obtención de nuevos derivados que, en la …
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Studies to determine the mechanisms of the anti-atherosclerotic effects of eicosapentaenoic acid: possible role for endocannabinoids?
… tissues and, since synthetic cannabinoid agonists have been shown to exert anti-atherosclerotic effects, this thesis explored whether a link exists between the endocannabinoid system and the beneficial effects of ω-3 PUFAs in the setting of experimental atherosclerosis. Therefore, the …
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Étude Raman des supraconducteurs organiques
… de phase supraconductrice sur le mode C=C ? 2 (Ag) a été mise en évidence et le transfert de charge a été estimé à ? =.5 e pour les deux composés. Ce travail s'insère dans l'effort global du laboratoire voulant établir un lien entre les supraconducteurs organiques et les composés d'oxydes de …
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ABHD16A-proteiinia inhiboivien yhdisteiden toksisuuden tutkiminen hiiren kortikaalihermosoluilla
… lipidivälittäjäaine arakidonyyliglyserolia (2-AG) ja sen metaboliiteilla on endokannabinoidijärjestelmän kautta merkittävä vaikutus hermotulehdukseen. ABHD12 ja ABHD16A olivat tämän tutkielman keskiössä fosfatidyyliseriiniä ja proinflammatorinen lysofosfatidyyliseriiniä säätelevinä entsyymeinä. …
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Targeting the Endocannabinoid System to Reduce Inflammatory Pain
… anandamide (AEA) and 2-arachidonylglycerol (2-AG) exert their effects predominantly through cannabinoid CB1 and CB2 receptors, but these actions are short-lived because of rapid hydrolysis by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respectively. Selective …
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CANNABINOID RECEPTORS (CB) IN COCHLEA: CHARACTERIZATION AND OTOPROTECTIVE FUNCTIONS
… anandamide (AEA) and 2-Arachidonyl glycerol (2-AG), enzymes involved in their biosynthesis and degradation such as diacylglycerol lipase-α (DAGL- α), and CB receptors. Primarily, there are three types of CB receptors - CB receptor 1(CB1), CB receptor 2 (CB2) and non CB1 non CB2 types of CB …
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Cannabinoid Modulation of Reinforcement Maintained by Stimulation of the Medial Forebrain Bundle in C57Bl/6J Mice
Cannabinoid agonists, including marijuana containing delta-9-tetrahydrocannabinol (THC), are found rewarding by humans. In addition to human self-reports and experimental studies that show marijuana is rewarding, contributions from preclinical studies also have implicated cannabinoid receptors in …
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An investigation into the role of cannabinoid and group 1 metabotropic glutamate receptors in the control of rhythmic locomotion in hatchling Xenopus Laevis
… Alzheimer’s, depression, schizophrenia and fragile X syndrome. Alongside this, group 1 mGluRs are linked, via the production endocannabinoid 2-archidonyl glycerol (2-AG), to cannabinoid receptor 1 (CB1). CB1 is one of the most highly expressed G-protein coupled receptors (GPCRs) in the central …
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