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Showing 1 to 12 of 12 for “"2'-fucosyllactose"”.
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Production of a functional human milk oligosaccharide, 2'-fucosyllactose, using microbial cell factories
… the host immune system. Among HMOs, 2’-fucosyllactose (2-FL), composed of L-fucose and D-lactose, is known to possess an anti-infection capability against many harmful organisms such as Campylobacter jejuni, enteropathogenic Escherichia coli, and even Norovirus. Consequently, great …
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The effects of 2’-fucosyllactose and Bifidobacterium longum subspecies infantis supplementation on growth, intestinal development and immune development and function in piglets
… to meet their nutritional requirements. 2′-fucosyllactose (2′-FL) is a human milk oligosaccharide (HMO) abundant in human milk and has been shown to have effects on intestinal and immune development and function. Bifidobacterium longum subsp. Infantis (B. infantis) is a commensal bacterium …
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Technical and economic viability of value added product recovery in the corn dry grind ethanol process
… internal rate of return among the processes. 2’-fucosyllactose (2’-FL) is one of the most abundant human milk oligosaccharides and has been linked with reduced risks of fatality and intestinal dysfunction in infant piglets. However, high costs associated with synthesis and purification restrict …
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Engineering microorganisms for synthesizing value-added products
… titer and productivity of a target product (2’-Fucosyllactose) in engineered E. coli. The second goal of my thesis study was to enhance the production of a target product (2’-fucosyllactose) in engineered S. cerevisiae by reducing by-product (ethanol) production. The second objective was based …
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Dietary Manipulation at Pre-Conception and During Development Influence Metabolism and Gut Microbiota in Rats
… 1) Weanling male and female rats consumed 2’Fucosyllactose and 3’Sialylactose HMO-fortified diet for 8 weeks. Fathers consumed 2) a diet high in protein, 3) a high fat/ sucrose diet fortified with a methyl donor cocktail of betaine, choline, folic acid and vitamin B12, or 4) a high prebiotic …
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Human milk oligosaccharide supplementation did not affect gut development in the healthy neonatal piglet
… replacer with 0.351g per kg of body weight of 2’fucosyllactose (2’FL). Gastric and intestinal samples were harvested on PD1, PD14, and PD28 and analyzed with immunohistochemistry. Villus and crypt lengths were measured in the small intestinal sections, and mucosal thickness was measured in the …
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Effects of 2ʹ-fucosyllactose on brain and cognitive development of intrauterine growth restricted piglets
… abundant solid component of breast milk with 2′-fucosyllactose (2′FL) being the most abundant HMO. We aimed to determine whether orally administered 2′FL enhances brain and cognitive development in small for gestational aged neonates. Sex-matched, littermate pairs of SGA (0.5-0.9kg) and …
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Maternal stress signature and infant neurodevelopment: determining the beneficial effects of human milk oligosaccharides - an in vitro study
… Using SH-SY5Y cells, the role of the HMOs 2′-Fucosyllactose (2’-FL) and 3’-Sialyllactose (3’-SL) on neuronal development in the presence of different stressors was studied. We treated SH-SY5Y cells with 100ng/ml tumour necrosis factor-alpha (TNF-) to create a stressed SH-SY5Y cell model. 3 …
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Probiotic metabolism of human milk oligosaccharides (HMOs) and prebiotics
… (3’-SL), 6’-Sialyllactose (6’-SL), 2’- Fucosyllactose (2’-FL) and 3’- Fucosyllactose (3’-FL), yet four lactobacilli demonstrated moderate growth with LNnT, (4) amongst the bifidobacteria strains, only B. infantis ATCC 15697 and B. infantis M-63 were able to ferment 3'-SL, 6’-SL, 2’-FL …
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In vitro model development for novel prevention measures against foodborne pathogens
… carbohydrate structures, namely mannose and 2-fucosyllactose respectively. Subpopulations of E. coli, for example, could be separated based on the predominance of mannose-binding fimbriae. The mechanism by which C. jejuni adheres to fucose remains to be determined, but the development of this …
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Bifidobacterial interactions with human milk oligosaccharides and their combined potential for the advancement of infant nutrition
… specific combinations of HMOs, particularly 2’-fucosyllactose (2’-FL) and 6’-sialyllactose (6’-SL), were effective in modulating immune responses. These HMOs significantly reduced pro-inflammatory cytokine levels in the co-culture human cell model, indicating their potential to mitigate …
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The role of probiotics, prebiotics, and human milk oligosaccharides in infant formulae
… mg /L plus lactose + N-acetyllactosamine); b) 2'-fucosyllactose (2'FL) at 0, 20, 200 or 2000 mg/L or energy control (0 mg/L plus lactose + fucose); c) 6'sialyllactose (6'SL) at 0, 40, 400, 4000 mg/L or energy control (0 mg/L plus lactose + sialic acid). Dependent variables in study 2 included …