Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 463 for “"1A"”.
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Molecular mechanisms of nutrient mediated regulation of hypoxia inducible factor -1a(HIF-1a) in endothelial cells.
… of hypoxia-inducible factor-alpha (HIF-1alpha). In an animal model of diabetes, HIF-1alpha protein expression was seen to increase in the vasculature surrounding the sciatic nerve at ten- and twenty-four weeks of diabetes duration, which was seen to be reversed at twenty-four weeks in …
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Estrogen and 5-HT(1A) receptor function
The effects of estrogen treatment on 5-HT1A receptor function were examined. When ovariectomized rats were given a single treatment with 25 μm estradiol benzoate followed 48 hr later with 500 μg progesterone, the 5-HT1A receptor agonist, 8-hydroxy-2(di-n-propylamino) tetralin (8-OH-DPAT), inhibited …
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Estrogen and 5-HT(1A) receptor function
The effects of estrogen treatment on 5-HT1A receptor function were examined. When ovariectomized rats were given a single treatment with 25 μm estradiol benzoate followed 48 hr later with 500 μg progesterone, the 5-HT1A receptor agonist, 8-hydroxy-2(di-n-propylamino) tetralin (8-OH-DPAT), inhibited …
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Klonierung und Charakterisierung der Caseinkinase-1a aus Neurospora crassa
… Doubletime (DBT) aus D. melanogaster homologe CK-1a aus N. crassa kloniert und charakterisiert werden. Es wurde auch eine zweite zur humanen Caseinkinase 1ε homologe Kinase - CK-1b - in N. crassa identifiziert. Das für CK-1a kodierende Gen ist näher mit DBT verwandt. Daher wurde CK-1a in E. coli …
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A novel function for the eukaryotic translation elongation factor 1A
The eukaryotic translation elongation factor 1A, eEF1A, a homolog of the bacterial EF1A (formerly known as EF-Tu), is a well-characterized ribosome associated factor, responsible for the delivery of aminoacyl-tRNAaa to the ribosomal A site. In contrast to this indirect interaction with the nascent …
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Die Funktionelle Rolle der Palmitilierung des 5-HT 1A Rezeptor
… dieser Studie wurde demonstriert, dass der 5-HT (1A) Rezeptor durch tioester-type Bindung palmitoyliert ist. Die Palmitoylierung wird nicht durch die Stimulation mit den Agonisten moduliert. Durch die Proteinsynthese Blockierung wurde gezeigt dass die Palmitilierung abhängig von der …
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유두상갑상선미세암에서혈관내피성장인자(VEGF),혈관내피성장인자수용체-1(VEGFR-1),저산소증유발인자(HIF-1a)의mRNA발현
"목적: 신생혈관생성(angiogenesis)은 암종양의 성장 및 전이에 반드시 필요하며 혈관내피성장인자(vascular endothelial growth factor, VEGF)는 신생혈관생성 (angiogenesis)을 일으키는 중요한 인자로 알려져 있다. 최근 진단기술의 발달로 촉지되지 않는 10mm미만의 유두상 갑상선 미세암(papillary thyroid microcarcinoma, 유두상 미세암)의 진단이 급격히 증가하고 있다. 본 연구는 유두상 미세암 조직에서 VEGF와 VEGF의 수용체인 혈관내피성장인자수용체 …
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Ruta de Innovación y Sostenibilidad Empresarial (Modelo Rise): 1a Ingeniería S.A.S.
… Empresarial) presentado para la empresa 1A Ingeniería. Para el desarrollo de este modelo, se llevaron a cabo reuniones con la Gerencia General y el equipo de trabajo (dirección contable, auxiliar contable y administrativa, soporte técnico y área comercial) para comprender la situación …
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Sema-1a Reverse Signaling Promotes Midline Crossing In Response To Secreted Semaphorins
… mutations in the transmembrane semaphorin, Sema-1a. Mutations in sema-1a also dominantly enhance crossing defects in a netrin mutant, indicating that Sema-1a functions in a Netrin independent pathway to promote midline crossing. Here we identify the transmembrane Semaphorin, Sema-1a, as a novel …
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ASTROCYTIC REGULATION OF DOPAMINE-DEPENDENT PHENOTYPES RELEVANT TO SCHIZOPHRENIA THROUGH DYSBINDIN-1A
… che gli astrociti esprimono solo l'isoforma Dys1A mentre i neuroni esprimono sia le isoforme Dys1A che Dys1C. Sorprendentemente, solo l'espressione di Dys1A è ridotta nel nucleo caudato dei pazienti schizofrenici rispetto ai soggetti di controllo. L'abolizione di Dys1A ubiquitaria o …
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Serotonin 1A Receptor Signaling in the Hypothalamic Paraventricular Nucleus of the Peripubertal Rat
… wealth of existing comparative data on serotonin 1A (5-HT1A) receptor signaling in adult hypothalamic rat paraventricular nucleus (PVN).</p> <p>Given the clinical relevance of potential age-dependent differences in serotonergic signaling and regulation of hypothalamic function, the objective of …
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CANNABINOID RECEPTOR INTERACTING PROTEIN 1A (CRIP1A): EFFECTS ON CB1 RECEPTOR FUNCTION AND CELLULAR REGULATION
… The Cannabinoid Receptor Interacting Protein 1a (CRIP1a) binds to the extreme carboxy terminus of CB1R, and has been shown to alter CB1R-mediated neuronal function. The mechanisms by which CRIP1a regulates CB1R activity and trafficking have not yet been identified; therefore the focus of this …
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Modelamiento matemático y simulación de procesos para sistemas de tratamiento de aguas 1a. parte
El campo del tratamiento de aguas residuales ha experimentado en las últimas décadas, importantes avances exigidos por los continuos cambios en las características de las aguas residuales, debido a una diversa cantidad de sustancias que llevan consigo. Con el fin de satisfacer los requerimientos de …
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Freud-1, a novel regulator of the dopamine D2 and serotonin 1A receptor genes
… which is implicated in the regulation of the 5-HT1A receptor and is genetically linked to non-syndromic mental retardation. Initially, I have characterized the repressor activity of a novel long isoform of human Freud-1 and shown that it is the major isoform expressed in human cells, and that it …
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Pharmacological Studies of the Signal Transduction Pathways of the a 1a-Adrenbrgic Receptor Subtype
… norepinephrine and epinephrine. Three 1a-AR subtypes (a1a, a1b, a1d) have been cloned and classified. cpa-ARs couple to phosphoinositide hydrolysis, adenylyl cyclase, and mitogen activated protein kinase (MAPR) pathways. In some systems, the adenylyl cyclase pathway, including adenosine …
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Characterisation of YGT a novel Type III secretion system in Biotype 1A Yersinia enterocolitica strain YE53/03
Biotype (BT) 1A Yersinia enterocolitica is considered a group of organisms that is harmless given the lack of classical virulence factors, characteristic of pYV bearing strains. BT 1A Y. enterocolitica strains are common in the environment and in livestock, particularly the pig, with no adaption to …
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Déploiement et évaluation d’une offre de test de dépistage néonatal pour le rachitisme vitamino-dépendant de type 1A
Vitamin D-Dependent Rickets Type 1A (VDDR1A) is an autosomal recessive inherited disease caused by variants in the CYP27B1 gene, which is required for vitamin D activation. Although rare worldwide, the prevalence is 1 in 2916 births in the Saguenay-Lac-Saint-Jean (SLSJ), Haute-Côte-Nord (HCN) and …
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The interactions of the cucumber mosaic virus 2b protein with the viral 1a and host Argonaute 1 proteins
… to establish that another CMV protein, the 1a replication protein, also binds to the 2b protein and modulates the 2b-mediated inhibition of AGO1 activity. This prevents induction of aphid resistance in CMV-infected *A. thaliana* plants and represents a novel regulatory system in which viral …
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Imaging Nociceptin Receptor Expression in Cannabis Use and Psychosis using Positron Emission Tomography with the radioligand [11C]NOP-1A
… using the highly specific ligand [11C]NOP-1A and positron emission tomography (PET). Study participants with long-term cannabis use and diagnosed as Clinical High Risk (CHR) and First Episode Psychosis (FEP) were included in the present work. The target regions of interest (ROI) include …
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