Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 93 for “"18F"”.
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Late stage 18F-difluoromethylation of N-heteroaromatics
… methodology for the late stage addition of CHF18F to N-heteroaromatics for PET imaging. This methodology proceeds via C-H activation, under flow photoredox conditions. The 18F-difluoromethylation relies on the use of a new 18F-difluoromethylating reagent derived from the Hu’s reagent. This …
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Imaging atherosclerotic plaque inflammation with [18F]- fluorodeoxyglucose positron emission tomography
Inflammation is important in both the pathogenesis and outcome of atherosclerosis. Plaques containing numerous inflammatory cells, particularly macrophages, have a high risk of rupture, whereas those with fewer inflammatory cells are at lower risk. The current ‘gold standard’ technique for imaging …
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Development of 18F radiochemistry for positron emission particle tracking (PEPT)
… from commercially available medical grade 18F-fluorodeoxyglucose (18F-FDG) (half-life 110 minutes) was developed. In the context of the radioisotopes and accelerated beams available through the National Research Foundation (NRF) accelerator facility iThemba LABS (Cape Town, South Africa), …
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Measurement of glucose metabolism using positron imaging and 18F-labeled analogs
Thesis: Sc. D., Massachusetts Institute of Technology, Department of Nuclear Engineering, 1980
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I. Development of novel silicon precursors for rapid and efficient radiofluorination reactions: synthesis and biological evaluation of a 18f-labelled estrogen dendrimer conjugate II. Other studies on 18f-labelled estrogens
… beyond the most commonly used PET tracer, [18F]fluorodeoxyglucose, including the use of large, sensitive biomolecules such as peptides and antibodies, which may be of considerable clinical importance. However, the available methodology associated with PET isotope incorporation, specifically …
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Correlation of Hepatic 18F-Fluorodeoxyglucose Uptake with Fatty Liver and Liver Function Tests
Liver demonstrates heterogenous FDG uptake pattern and sometimes shows abnormally increased uptake even though there is no malignant tissue. There was no previous study to correlate these various pattern of hepatic FDG uptake with benign liver disease. Therefore, we evaluated the significance of …
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Usefulness of [18F]-Deoxyglucose Positron Emission Tomography in Diagnosing the Patients with Corticobasal Degeneration
… hypometabolism was demonstrated in the previous [18F]-deoxyglucose positron emission tomography (FDG PET) scan studies. We investigated the hypometabolic pattern of Korean CBD patients using quantitative FDG PET and voxel based comparison method. METHODS: Twelve patients with CBD and 16 …
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Charakterisierung von 16alpha-[18F]Fluorestradiol-3,17beta-disulfamat als potentieller Tracer für die Positronen-Emissions-Tomographie
… Die derzeit eingesetzten PET-Tracer 2-[18F]Fluor-2-desoxy-D-Glucose (FDG) und 16a-[18F]Fluor-17b-estra--diol (FES) können Mammakarzinome bzw. deren Metastasen nicht mit 100%iger Sicherheit nachweisen. Aus diesem Grund wurde eine [18F]-markierte Verbin-dung entwickelt, die möglicherweise …
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The threshold of clinical severity of cervical dystonia for positive 18F-FDG PET/CT study
… clinical severity of cervical dystonia (CD) and 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) findings and to determine the threshold of the clinical severity of CD for acquisition of positive 18F-FDG PET/CT study findings. METHODS: Forty-seven subjects …
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The Role of 18F-FDG PET/CT in the Diagnostic Algorithm for Malignant Epithelial Head and Neck Cancers (MEHNC) // Роля на 18F-FDG ПЕТ/КТ в диагностичния алгоритъм при злокачествените епителни тумори на глава и шия
… дисертационния труд беше да определим ролята на 18F-FDG ПЕТ/КТ в диагностичния алгоритъм при злокачествени епителни тумори на глава и шия. Изготвихме следните задачи: да определим ролята на ПЕТ/КТ за първична диагностика на неясно първично огнище (НПО), при пациенти с доказани метастатични шийни …
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Comparison of 18F-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (18F-FDG PET/CT) and conventional imaging (CI) for locally advanced breast cancer staging: a prospective study from a tertiary hospital cancer centre in Western Cape
… Increasing evidence shows that the use of 18F-FDG PET/CT for disease staging of LABC may improve diagnostic sensitivity. Aim: To prospectively assess the difference in diagnostic accuracy between whole-body PET/PET-CT and conventional imagine (CI) for staging LABC. Methods: A total of 42 …
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Molecular imaging of calcification and inflammation in aortic valve disease and atherosclerosis
… (CT) and molecular processes (PET) in vivo. The 18F-sodium fluoride (18F-fluoride) isotope has shown promise in early cardiovascular studies. The purpose of this thesis was to elucidate the mechanisms of cardiovascular 18Ffluoride uptake and define how 18F-fluoride PET/CT might play a role in the …
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Imagenología de las infecciones por Enterobacterales a través del estudio por Tomografía por Emisión de Positrones con 18F-Fluorodeoxisorbitol
… de investigadores identificó el radiotrazador 18F- Fluorodeoxisorbitol conocido como (18F-FDS); substrato metabólico específico para los Enterobacterales, el cual a través del operón srl conformado por 3 subunidades constituyen el sistema de fosfotransferasa dependiente de sorbitol, el cual …
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The development of a simple process for producing medicinal diagnostic 18F agents for molecular imaging using positron-emission-tomography
… (RLV) approach for the synthesis of [18F]-fluoride radiotracers for use as imaging agents in positron-emission-tomography (PET). The RLV strategy immobilises a precursor to the desired radiotracer on a solid support which is cleaved on exposure to [18F]-fluoride ion to give the …
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Imaging microcalcium in thoracic aortic disease
… thoracic aortic atheroma and aneurysm formation. 18F-Sodium fluoride positron emission tomography (PET) identifies microcalcification not identifiable on conventionally computed tomography (CT). The aim of this thesis was to assess the application of 18F-sodium fluoride PET in identifying of …
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Development of Novel PET Radiotracers for Neuroinflammation and COVID-19: Targeting FPR2, I2BS and ACE2
… were developed to produce [11C]Quin C1 and [18F]Quin C1-click-F, two potential FPR2-targeting PET radioligands identified through collaboration with Imperial College London. Radiotracer [11C]Quin C1 was produced with decay-corrected radiochemical yield (d.c.RCY) (decay corrected to the start …
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Novel positron emission tomography applications for imaging cardiovascular disease activity
… Calcification activity can now be imaged using 18F-sodium-fluoride positron emission tomography and computed tomography which targets microcalcification (diameter <50 μm), providing different information to established macroscopic calcification (minimum diameter 200 to 500 μm) imaged with …
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Detecting tumour responses to treatment using metabolic imaging with hyperpolarised [1-13C]pyruvate and 2-([18F]fluoro)-2-deoxy-D-glucose
… that measure different parts of glycolysis, 2-([18F]fluoro)-2-deoxy-D-glucose positron emission tomography ([18F]FDG-PET) and hyperpolarised [1-13C]pyruvate magnetic resonance imaging), for the purpose of detecting early responses to treatment in mouse models of cancer. Two mouse models of …
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