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Showing 1 to 1 of 1 for “"17-allylamino-17demethoxygeldanamycin"”.
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Mechanism-Based Strategies to Enhance The Actions of A
… and hydrolysis of ATP. The geldanamycin analog, 17-AAG, binds to the ATP pocket of HSP90 leading to the degradation of client proteins. However, treatment with 17-AAG results in the elevation of the levels of antiapoptotic proteins HSP70 and HSP27, which may lead to cell death resistance. The …