Global ETD Search
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Showing 1 to 3 of 3 for “"14-3-3sigma"”.
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14-3-3Sigma Negatively Regulates The Stability and Subcellular Localization of Cop1
… mechanism remains unknown. We discovered that 14-3-3σ controlled COP1 subcellular localization and protein stability. Investigation of the underlying mechanism suggested that, upon DNA damage, 14-3-3σ bound to phosphorylated COP1 at S387, resulting in COP1 translocation to the cytoplasm and …
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A Study On The Function of 14-3-3Sigma In Regulating Cancer Energy Metabolism
… and tumorigenesis. In this study, we find that 14-3-3σ suppresses all these three metabolic processes by promoting the degradation of their main driver, c-Myc. In fact, 14-3-3s significantly enhances c-Myc poly-ubiquitination and subsequent degradation, reduces c-Myc transcriptional activity, …
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Molecular mechanisms of acquired gemcitabine resistance in pancreatic cancer
… to the parental cell line. I found that 14-3-3σ is up-regulated in the drug resistant cell line due to demethylation in its first exon, and the up-regulation of 14-3-3σ gene expression, in turn, contributes to gemcitabine resistance. Intriguingly, I found that demethylation of the 14-3-3σ …