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Showing 1 to 7 of 7 for “"14-3-3s"”.
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Purification of protein phosphatases and 14-3-3-binding proteins and their regulation by the cAMP–PKA pathway
… creates binding sites for proteins such as 14-3-3s, which have been shown to dock onto dually-phosphorylated serine/threonine residues on target proteins. In chapter 4, I looked at the regulation of 14-3-3-binding proteins when the cAMP–PKA signalling pathway was activated. Again, I used …
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A Study On The Function of 14-3-3Sigma In Regulating Cancer Energy Metabolism
… and tumorigenesis. In this study, we find that 14-3-3σ suppresses all these three metabolic processes by promoting the degradation of their main driver, c-Myc. In fact, 14-3-3s significantly enhances c-Myc poly-ubiquitination and subsequent degradation, reduces c-Myc transcriptional activity, …
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Crosstalk of protein phosphorylation and lysine acetylation on 14-3-3 proteins and their applications in brassinosteroid signaling and photosynthesis
… acetylation occurred to an Arabidopsis protein, 14-3-3ω. 14-3-3ω is a member of the 14-3-3 family of proteins that have been widely found in plants. 14-3-3s function mainly as phosphoserine/phosphothreonine-binding proteins that can affect the enzymatic activity, subcellular localization or …
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A Regulatory Role for 14-3-3 Proteins in the Starch Biosynthetic Pathway of Zea mays
… A class of eukaryotic proteins called “14-3-3” dimerize and interact with phosphorylated clients to regulate enzymatic activity, localization and protein interactions. A series of bioinformatic and biochemical techniques identified GF14-6 as the only detectable 14-3-3 isoform in maize …
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Molecular cloning and characterization of nitrate reductase from Ricinus communis L. heterologously expressed in Pichia pastoris
… (Ser-526) innerhalb des möglichen 14-3-3 Bindemotivs 523KSVS*TP528, was eine allgemeine Eigenschaft von Nitratreduktasen ist. Im C-Terminus von Ricinus NR bestätigte die Sequenz 886CGPPP890, dass die Ricinus NR ein NADH-spezifisches Enzym ist. Die Ricinus NR und Arabidopsis NR2 …
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Developmental Deregulation and Tumorigenesis Inhibition In 14-3-3Zeta Knockout Mouse
… related death in women of the United States. 14-3-3s are a family of conserved proteins ubiquitously expressed in all eukaryotic organisms. They form complexes with hundreds of proteins by binding to specific phospho-serine/threonine containing motifs. In this way they regulate a variety of …
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Regulation of human protein kinases and phosphatases by 14-3-3
… and its paralogues FAM122B and FAM122C are 14-3-3-binding phosphoproteins. The binding of 14-3-3 to FAM122A is mediated by phosphorylation of Ser37 and Ser62; the latter being a site that is phosphorylated in response to cAMP-elevating agents. Binding of 14-3-3 does not affect the …