Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"14-3-3 Proteins"”.
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Crosstalk of protein phosphorylation and lysine acetylation on 14-3-3 proteins and their applications in brassinosteroid signaling and photosynthesis
… acetylation occurred to an Arabidopsis protein, 14-3-3ω. 14-3-3ω is a member of the 14-3-3 family of proteins that have been widely found in plants. 14-3-3s function mainly as phosphoserine/phosphothreonine-binding proteins that can affect the enzymatic activity, subcellular localization or …
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Design of Peptide Ligands for 14-3-3ε, and Exploring the Role of Residue Types in Ligand Recognition by 14-3-3 Proteins
The 14-3-3 family of proteins are implicated in various malignancies. In cutaneous squamous cell carcinoma (cSCC), overexpression of the 14-3-3ε isoform is associated with suppression of apoptosis. Like 14-3-3ε, the protein phosphatase cell division cycle 25 A (CDC25A) is over expressed and …
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Identification of new genes and pathways that act to delay C. elegans aging
… transcription factor DAF-16. We discovered that 14-3-3 proteins play a role in C. elegans lifespan determination. 14-3-3 proteins interact with the SIR-2.1 protein, and the 14-3-3 genes par-5 andftt-2 are required for the longevity mediated by sir-2. I1 overexpression, indicating that 14-3-3 …
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Methionine Sulfoxide Reductase and Ubiquitin-dependent Degradation of Alpha-synuclein
Alpha-synuclein (αSyn) is one of the key proteins considered to be involved in the pathogenesis of the Parkinson`s disease (PD) and being the main component of Lewy bodies (LBs). Studies on the αSyn gene mutants and overexpression of αSyn in yeast and rodent brains indicate that the level of αSyn …
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Role of Phosphorylation In The Regulation of Prmt5
<p>PRMT5 is a member of a group of proteins that mediate arginine methylation. It is involved in diverse cellular processes, including cell differentiation, splicing, transcription elongation and epigenetic silencing, and its expression is dysregulated in many cancers. Due to its pleiotropic …
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Analysis of SMAUG1 protein motifs and interacting partners - linking regulation of phase separation to human disease
RNA-binding proteins (RBPs) are central regulators of gene expression, influencing RNA processing, localisation, translation, and decay. A growing body of evidence shows that many RBPs exert their functions through the formation of dynamic, membrane-less organelles (MLOs) via liquid–liquid phase …
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Determining the effects of phosphorylation on AFAP-110 function
… revealed that AFAP-110 contains twelve potential 14-3-3 binding sequences. 14-3-3 proteins are a family of small acidic adaptor proteins of dimeric nature that act as molecular scaffolds and/or allosteric regulators in a number of cellular pathways. We have been interested to determine whether …
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The TAZ Protein Interactome in Striated Muscle
… components in myogenic cells. TAZ interacting proteins include components of Hippo signalling: TEAD1-4, LATS1, 14-3-3 proteins. Epigenetic regulators were also represented: NuRD complex, FACT complex, and SWI/SNF complex. We focused on characterizing the TAZ interaction with the Wnt …
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Functional Interactions Between Par-1b Protein Kinase and RNF41 E3 Ubiquitin Ligase
… from membranes to the cytosol and to bind 14-3-3 proteins. In 2004, Brajenovic, et al. reported the results of a study that used tandem affinity purification: TAP) to isolate human Par-1d along with associated proteins. Nrdp1/RNF41, a RING finger E3 ligase was identified in their screen …
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Investigating the functional roles of the viral frameshift protein 2B* in EMCV infection
… is further heightened by the ability of EMCV proteins to antagonise the host innate immune system, reducing the antiviral response. In 2011 the genome of EMCV was found to encode a thirteenth viral protein, 2B*, in an overlapping open reading frame within the gene for 2B. 2B* is translated via …
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Pyp3 Involvement in Mitotic Control and Cell Growth in Fission Yeast
… used to isolate S. pombe cDNA clones encoding proteins that interact with Pyp3. One of the positive interacting proteins is tif1. eIF4E (Tif1) is the mRNA cap-binding protein and essential for recruitment of ribosomes to mRNA. Our results show that Pyp3 physically interacts with eIF4E in vivo …
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Cellular mechanisms that modulate kainate receptor trafficking and assembly
… determinants are presumed to bind to chaperone proteins, but these proteins have not been identified for any KAR subunit. Here we identified two chaperone proteins that associated with the carboxy terminus but differently regulated the localization of KA2 receptors. We found that coatomer …
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The identification of biomarkers of chemotherapy resistance in breast cancer using comparative proteomics
… performed, to identify differentially expressed proteins (DEPs) between CS and CR invasive ductal carcinoma samples, using 2-dimensional polyacrylamide gel electrophoresis (2D-PAGE) with MALDI-TOF/TOF mass spectrometry and antibody microarray analysis. DEPs were submitted to Ingenuity Pathway …
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The Hippo Signaling Pathway in Organ Size Control and Regeneraton
… obtained both genetic and cellular evidence that 14-3-3 proteins are involved in this process. I also identified three Serine residues (S111, S168 and S250 of Yki as essential for restricting Yki activity. I found that 14-3-3 regulates Yki subcellular localization mainly through S168 but not the …
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LKB1 signaling pathways in adipocytes - Focus on the AMPK-related kinase SIK2
… identified and shown to mediate a binding to 14-3-3 proteins, resulting in a re-localization from a particulate fraction to the cytosol, and a decrease in activity, respectively. In addition, we suggest that the transcriptional regulators CREB-regulated transcription co-activator (CRTC) 2, -3 …
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Examination of Placenta and Child Saliva Samples Associated with Childhood Allergy Development
… The aim of this PhD thesis was to identify proteins associated with childhood allergy using two sources of biological tissue: placental tissue and child saliva. The long term objectives were to identify proteins that could be measures of allergic risk in placenta and saliva, develop an assay …
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Characterisation of dysregulated proteins in macrophages infected with Mycobacterium smegmatis focusing on matrix metalloproteases and their effectors
… generated data was used to evaluate dysregulated proteins and those that act as upstream and downstream effectors of MMPs. The phenotypic changes induced by M. smeg were also analysed. In addition to that, the hosts’ response to lipoarabinomannan H37Rv (LAM) treatment was assessed by discovery …
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Protein kinases in hormonal regulation of adipocyte metabolism.
… coincides with an increase in binding of SIK3 to 14-3-3 molecules. 14-3-3 proteins are cellular scaffolding proteins that can result in cellular re-localization of their binding partners or in their binding to other proteins or lipids. We find that when SIK3 is phosphorylated in response to …