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Showing 1 to 20 of 65 for “"14-3-3"”.

  1. Protein kinases that phosphorylate 14-3-3 isoforms

    Clokie, Samuel J. H.The University of Edinburgh2006

    14 -3 -3 is an abundant, predominantly phospho-binding protein, intimately involved in the regulation of many diverse signal transduction events including cell cycle regulation, nucleo-cytoplasmic targeting of essential transcription factors and regulation of catecholamine synthesis. The 14 -3 -3 …

    edinburgh Repository record

  2. Die Rolle der 14-3-3-Proteine beim Vorwärtstransport von Kaliumkanälen

    Heusser, KatjaUniversität Heidelberg

    … zum ER zurückgeführt, während zytosolische 14-3-3-Proteine am Vorwärtstranport zur Plasmamembran beteiligt sind. Im Verlauf dieser Arbeit konnte gezeigt werden, dass 14-3-3-Proteine nicht nur spezifisch Kir6.2-Reporterproteine binden können, sondern dass diese Proteine am Transport des …

    heid-diss Repository record

  3. Regulation of human protein kinases and phosphatases by 14-3-3

    Murugesan, GavuthamiUniversity of Dundee2015

    … and its paralogues FAM122B and FAM122C are 14-3-3-binding phosphoproteins. The binding of 14-3-3 to FAM122A is mediated by phosphorylation of Ser37 and Ser62; the latter being a site that is phosphorylated in response to cAMP-elevating agents. Binding of 14-3-3 does not affect the …

    dundee Repository record

  4. Arabidopsis 14-3-3 Epsilon-Gruppe: Ihre Bedeutung für Wachstums- und Differenzierungsprozesse

    Naumann, Sarah2016

    tuebingen

  5. Regulation of Mammary Gland Development and Tumorigenesis By 14-3-3 Zeta

    Rehman, Sumaiyah2015

    … during cancer initiation and progression. 14-3-3z is overexpressed in more than 40% of breast cancers and is associated with poor patient prognosis. Therefore, the function of 14-3-3z in cancer and normal mammary gland development was investigated utilizing multiple <em>in vivo</em> and …

    uthsc Repository record

  6. Untersuchungen zur dynamischen Regulation der Interaktion von RGS7 mit dem Adapterprotein 14-3-3

    Johnsen, Marc

    … Eine entscheidende Rolle hierbei spielt 14-3-3, das mit RGS7 phosphorylierungsabhängig interagiert. Für die Promotionsarbeit ergab sich daraus nun die Frage, wann RGS7 an 14-3-3 gebunden ist und welche Mediatoren die Bindung beeinflussen? Von besonderem Interesse war der vermehrt im …

    freiburg-diss Repository record

  7. α-synuclein is colocalized with 14-3-3 and synphilin-1 in A53T transgenic mice

    Shirakashi, YoshitomoKyoto University2009

    kyoto Repository record

  8. A Regulatory Role for 14-3-3 Proteins in the Starch Biosynthetic Pathway of Zea mays

    Carswell, MatthewUniversity of Guelph2021

    … A class of eukaryotic proteins called “14-3-3” dimerize and interact with phosphorylated clients to regulate enzymatic activity, localization and protein interactions. A series of bioinformatic and biochemical techniques identified GF14-6 as the only detectable 14-3-3 isoform in maize …

    guelph Repository record

  9. Purification of protein phosphatases and 14-3-3-binding proteins and their regulation by the cAMP–PKA pathway

    Reetoo, NamrataUniversity of Dundee2012

    … creates binding sites for proteins such as 14-3-3s, which have been shown to dock onto dually-phosphorylated serine/threonine residues on target proteins. In chapter 4, I looked at the regulation of 14-3-3-binding proteins when the cAMP–PKA signalling pathway was activated. Again, I used …

    dundee Repository record

  10. 14-3-3 Zeta Overexpression Serves As A Novel Molecular Switch Turning Tgf-Beta From Tumor Suppressor to Tumor Promoter

    Xu, Jia2013

    … elusive. Here we identify that overexpression of 14-3-3ζ inhibits TGF-β’s cell cytostatic program through destabilizing p53 in non-transformed human mammary epithelial cells. Mechanistically, we found that 14-3-3ζ overexpression leads to 14-3-3σ downregulation, thereby activates PI3K/Akt signaling …

    uthsc Repository record

  11. Crosstalk of protein phosphorylation and lysine acetylation on 14-3-3 proteins and their applications in brassinosteroid signaling and photosynthesis

    Wu, XiaUniversity of Illinois at Urbana-Champaign2011

    … acetylation occurred to an Arabidopsis protein, 14-3-3ω. 14-3-3ω is a member of the 14-3-3 family of proteins that have been widely found in plants. 14-3-3s function mainly as phosphoserine/phosphothreonine-binding proteins that can affect the enzymatic activity, subcellular localization or …

    uiuc Repository record

  12. Design of Peptide Ligands for 14-3-3ε, and Exploring the Role of Residue Types in Ligand Recognition by 14-3-3 Proteins

    Kamayirese, SeraphineCreighton University2024

    The 14-3-3 family of proteins are implicated in various malignancies. In cutaneous squamous cell carcinoma (cSCC), overexpression of the 14-3-3ε isoform is associated with suppression of apoptosis. Like 14-3-3ε, the protein phosphatase cell division cycle 25 A (CDC25A) is over expressed and …

    creighton Repository record

  13. Determining the effects of phosphorylation on AFAP-110 function

    Cherezova, Lidia Nikolayevna2019

    … revealed that AFAP-110 contains twelve potential 14-3-3 binding sequences. 14-3-3 proteins are a family of small acidic adaptor proteins of dimeric nature that act as molecular scaffolds and/or allosteric regulators in a number of cellular pathways. We have been interested to determine whether …

    wvu Repository record

  14. Molecular mechanisms of acquired gemcitabine resistance in pancreatic cancer

    Qin, Li2014

    … to the parental cell line. I found that 14-3-3σ is up-regulated in the drug resistant cell line due to demethylation in its first exon, and the up-regulation of 14-3-3σ gene expression, in turn, contributes to gemcitabine resistance. Intriguingly, I found that demethylation of the 14-3-3σ …

    iupui Repository record

  15. Proteomic identification of putative biomarkers of neo-adjuvant chemotherapy resistance in luminal (ER+) breast cancer

    Hussain, TasadooqHull York Medical School, the University of Hull and the University of York2013

    … samples our research group recently identified 14-3-3 theta/tau, tBID and BcL-XL as putative biomarkers of response to neoadjuvant chemotherapy (Hodgkinson et al J Prot 2012, 75:1276-1283 and 75:2745-2752). Here we aimed to analyse further samples using the AbMA approach and to re-analyse the …

    hull Repository record

  16. Methionine Sulfoxide Reductase and Ubiquitin-dependent Degradation of Alpha-synuclein

    Deng, YueUniversity of Kansas2017

    … was found to bind Ub and the molecular chaperone 14-3-3 proteins, leading to enhanced αSyn aggregation. Our lab recently reported on elevated dopamine and 14-3-3 levels in the methionine sulfoxide reductase A (MsrA) knockout mouse brain, as well as decreased αSyn degradation in MsrA KO yeast …

    ku Repository record

  17. The identification of biomarkers of chemotherapy resistance in breast cancer using comparative proteomics

    Hodgkinson, Victoria C.University of Hull2011

    … in at least 2 datasets and these included 14-3-3 theta/tau, BID and Bcl-xL. Three datasets were generated using 2D-PAGE with MALDI-TOF/TOF MS, containing 132 unique DEPs. These included several isoforms of 14-3-3 proteins. The differential expression of 14-3-3, BID and Bcl-xL was confirmed …

    hull Repository record

  18. Identification of new genes and pathways that act to delay C. elegans aging

    Berdichevsky, AlinaMassachusetts Institute of Technology2008

    … transcription factor DAF-16. We discovered that 14-3-3 proteins play a role in C. elegans lifespan determination. 14-3-3 proteins interact with the SIR-2.1 protein, and the 14-3-3 genes par-5 andftt-2 are required for the longevity mediated by sir-2. I1 overexpression, indicating that 14-3-3 …

    mit Repository record

  19. Role of Phosphorylation In The Regulation of Prmt5

    Espejo, Alexsandra B2016

    … with several SH2-domain containing proteins, 14-3-3 proteins and the FHA domain of MDC1. These novel phospho-dependent PRMT5 interactions suggest that crosstalk between kinases and arginine methyltransferases may play a pivotal role in modulating the different cellular functions of PRMT5.</p> …

    uthsc Repository record

  20. Analysis of the role of Mdm38 in respiratory chain biogenesis

    Vollmer, Christine2012

    … Bereich ist auf tertiärer Ebene stark homolog zu 14-3-3 Proteinen und relevant für die Translationsregulation von Cox1 und Cob. Mdm38 kann daher als das erste 14-3-3-ähnliche mitochondriale Protein bezeichnet werden. Der identifizierte Bereich weist zudem Ähnlichkeit mit der vorhergesagten …

    goettingen Repository record

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