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Showing 1 to 3 of 3 for “"11beta-HSD1"”.
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Untersuchungen über Regulationsmechanismen der 11beta-Hydroxysteroid Dehydrogenase Typ 1
Die 11beta-HSD1 reguliert intrazellulär die Cortisolkonzentration durch Regeneration von Cortison z.B. aus dem Blutkreislauf, zu Cortisol. Daher stellt diese ein wichtiges Element in der Glucocorticoid-vermittelten Genregulation dar. Die 11beta-HSD1 wird ubiquitär exprimiert, auf hohem Niveau …
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Influence of Cellular Localization on Activity of Hydroxysteroid Dehydrogenases
… oxidoreductase family, particularly human 17beta-HSD1, which favors estrone reduction to estradiol. Rat AKR1C9 has also been thoroughly studied as a model HSD of the aldo-keto reductase family; AKR1C9 catalyzes the reduction of dihydrotestosterone to androstanediol. These two enzymes provide a …
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Modelling altered Glucocorticoid Sensitivity: From HPA axis to metabolic abnormalities in mice and humans
… (HPA) axis and cellular activity of 11beta- hydroxysteroid dehydrogenase (11beta-HSD) enzymes that interconvert active 11- hydroxy (corticosterone, cortisol) and inactive 11-keto (11-dehydrocorticosterone, cortisone) glucocorticoids. Here, the contribution of GR density and ligand …