Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"1101 Medical Biochemistry and Metabolomics"”.
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A study of rat skeletal muscle Troponin C isoforms
… heavy chain (MHC) isoform based fibre-typing and Sr2+ -activation measurements to explore the relationship between MHC and TnC isoform composition in mammalian skeletal muscle at the single fibre level, and to revisit the controversial issue of the relationship between TnC isoform composition …
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Cancer immunotherapy with Mucin-1 and cytokines
… altered form in cancers of the breast, pancreas, and ovary making an ideal target for immunotherapy. MUCl coupled to oxidised mannan (MFP), forms a powerful immunotherapeutic reagent capable of inducing tumour regression and cell mediated immune responses that protect against tumour challenge in …
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Renal Cannabinoid Receptor Expression and Function: Their Role in Obesity and Diabetes
Obesity and diabetes are clearly established independent risk factors for renal disease. Therapeutic targets have been investigated for their role in treating obesity and diabetic associated renal damage. The endocannabinoid system is an important endogenous lipid signalling system known to mediate …
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Assessing calcium absorption from fortified soymilk and fermented fortified soymilk in osteopenic post menopausal women
… compared to cows’ milk in post menopausal women, and to investigate ways of optimising the calcium bioavailability from commercially available CFSM. The project consisted of two parts: in vitro studies and the in vivo clinical studies.
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The effect of taurine on dystrophic muscle tissue function
… muscle, significantly impacting on the duration and quality of life. Despite the genetic defect and the missing protein dystrophin having been identified and characterised over 20 years ago, curative genetic therapies are still not clinically applicable, and corticosteroids, which are the only …
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Effects of kiwi-fruit seaweed extract on the metabolism of female reproductive hormones
… are especially known to impact on their mental and physical health. During the peri- menopausal years, a woman’s health can deteriorate and unfortunately may eventuate in severe diseases. The perspective on conventional and Chinese medicine is that there are interventions available for …
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Evaluation of the efficacy of a Chinese herbal medicine in the treatment of patients with osteoarthritis of the knee
… therapeutic drugs mainly treat OA symptoms and often cause undesirable side effects. Chinese medicine (CM) is a popular alternative therapy for OA, however the majority of CM efficacy studies have been methodologically inadequate. CM has traditionally treated OA under the clinical descriptor …
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An investigation of NADPH oxidase in normal and diseased skeletal muscle
… conditions, such as skeletal muscle wasting and therefore this study sought to determine a role for the superoxide generating NADPH oxidase and antioxidant enzyme systems in conditions of skeletal muscle wasting. The results of these studies indicated changes in the gene expression of …
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Skeletal muscle structure and metabolism in chronic heart failure
… tolerance. In study I, exercise tolerance and skeletal muscle metabolism and morphology were examined in 17 CHF patients and eight healthy similarly aged sedentary control subjects. In Study II, thirteen CHF patients participated in a study on the effects of resistance training on exercise …
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The physiological characteristics of elite women's basketball
… The game's ability to be played both indoors and outdoors, and the international popularity of the game make it an appealing sport for people of all ages. With an impressive 198 countries affiliated with the International Basketball Federation and an incredible 100,000,000 (one hundred …
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The physiological load imposed on basketball players during game play
… study was to investigate the intensities of work and the patterns of play during men's basketball and, in addition, to investigate the exercise metabolism that meets the energy demands of participation. Eight (8) male basketball players participating in the 1992 National Basketball League (NBL) …
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Expression and effects of epidermal growth factor related peptides in human term gestational tissue
This thesis w a s undertaken to détermine the expression of several growth factors that belong to the Epidermal Growth Factor ( E G F ) family in h u m a n term gestational tissue. It also examines the effects exerted by Transforming Growth Factor alpha (TGFa), a member of the E G F family, on …
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Alkalosis and digoxin effects on plasma potassium, ionic homeostasis and exercise performance in healthy humans
… to impaired muscle cell membrane excitability and fatigue. The magnitude of K+ changes are dependent on the size of contracting muscle mass, duration and intensity of exercise, and health and fitness status of participants. Activation of the sarcolemmal and t-tubular bound sodium-potassium …
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The effect of endurance training on human ammonia metabolism
… human ammonia (NH3) metabolism in trained and untrained individuals. Specifically, these aspects include: 1) plasma NH3 accumulation during exercise at similar absolute and relative work intensities; 2) plasma NH3 accumulation during recovery from maximal exercise; 3) the absolute and …
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Regulation of skeletal muscle glucose uptake during contraction/ exercise by nitric oxide (NO)/ neuronal nitric oxide synthase MU (NOSμ)
… to insulin-stimulated muscle glucose uptake and is normal in humans with type 2 diabetes (T2D) and in diabetic rodent models. A number of candidates have been implicated to play a role in the regulation of skeletal muscle glucose uptake during contraction and it is likely that there is some …
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Human aflatoxin exposure in south-western Ethiopia assessed using serum biomarkers: A thesis submitted in partial fulfilment of the requirements for the Degree of Master of Science at Lincoln University
… produced by the fungi Aspergillus flavus and A. parasiticus. Consumption of aflatoxin-contaminated food can cause hepatocellular carcinoma, immune suppression, child growth impairment, and death. The study aimed to assess aflatoxin exposure in South-western Ethiopian adults, using serum …