Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"11β-hydroxysteroid dehydrogenase"”.
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Structure-function analysis of 11β-hydroxysteroid dehydrogenase
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a key enzyme in the conversion of cortisone to the functional glucocorticoid hormone cortisol. This activation has been implicated in several human disorders, notably the metabolic syndrome where 11β-HSD1 has been identified as a novel target …
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Obesity, 11β-hydroxysteroid dehydrogenase and metabolic changes in the pathogenesis of idiopathic intracranial hypertension
… with dysregulation of cortisol metabolism by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). Additionally, 11β-HSD1 has a role in the regulation of intraocular pressure. This thesis hypothesised that 11β-HSD1 is involved in the aetiology of IIH and examined the roles of obesity, 11β-HSD1 …
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The role of 11β-Hydroxysteroid Dehydrogenase type 1 and Hepatic Glucocorticoid Metabolism in the Metabolic Syndrome
… focus on the microsomal enzyme 11\(\beta\)-hydroxysteroid dehydrogenase type 1 (11\(\beta\)-HSD1) which activates cortisone to cortisol in vivo. Through a series of in vitro and detailed translational studies, this thesis attempts to investigate hepatic glucocorticoid metabolism with …
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Role of 11β-hydroxysteroid dehydrogenase type 2 in protection against inflammation during atherogenesis: studies in the Apoe-/- /11β-HSD2-/- double knockout mouse.
… In mineralocorticoid-target tissues, 11β- Hydroxysteroid dehydrogenase type 2 (11β-HSD2) inactivates glucocorticoids, conferring aldosterone specificity upon the normally unselective MR. Recent evidence suggests that 11β-HSD2 may also afford protection of MR in the cells of the …
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Estrogen Regulation of the Pregnant Baboon Placental 11β-Hydroxysteroid Dehydrogenase (11β-HSD)-Catalyzed Metabolism of Cortisol and Cortisone and Its Effect on the Development of the Fetal Hypothalamic-Pituitary-Adrenal Axis
… peptide or CRH mRNA.</p> <p>Thirdly, since the 11β-hydroxysteroid dehydrogenase (11β-HSD)-catalyzed metabolism of maternal cortisol and cortisone by the placenta is an important component in the sequence of events regulating the function of the baboon fetal pituitary-adrenocortical axis, both …
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Placental 11b-hydroxysteroid dehydrogenase expression and birth weight in Hamilton County, TN
… restricted fetal growth. Placental production of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) inactivates cortisol before passage into the fetus. This study tests the hypothesis that increased placental 11β-HSD2 expression has a positive correlation with an individualized birth weight …
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The metabolism of cortisol in the human feto-placental unit
… Kinetic parameters of the human placental 11β-hydroxysteroid dehydrogenase system were assessed using a microsomal preparation in 50% glycerol buffer. The Michaelis constant for cortisol was 1.88 x 10-6M, in the presence of NADP, and 0.56 x 10-6M, in the presence of NAD. Vmax values varied …
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The ageing hair follicle environment. Alterations in the female scalp and mesenchyme with age.
… cyclin-dependent kinase inhibitor 2A (p16INK4A), 11β-Hydroxysteroid dehydrogenase type 1 and 2 (11β-HSD1/HSD11B1 and 11β-HSD2/HSD11B2) mRNA expression increased in aged DFs. In DS cells, HAS2, Vimentin (VIM) ,PDPN, Lysosomal-associated membrane protein 1 (LAMP1), Sequestosome- 1 (P62) and Protease …