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Showing 1 to 2 of 2 for “"1,6-benzyl elimination"”.
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Synthesis of Small Molecule and Polymeric Systems for the Controlled Release of Sulfur Signaling Molecules
… discussed in this dissertation leverages the 1,6-benzyl elimination reaction (or self-immolative reaction) to facilitate the release of a persulfide (R–SSH) from a small molecule prodrug platform as well as a separate system that releases COS/H₂S from a polymer. The self-immolative persulfide …
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Small Molecule and Macromolecular Donors of Reactive Sulfur Species: Insights into Reactivity and Therapeutic Potential
… systems described utilize the well-known 1,6-benzyl elimination reaction (sometimes called self-immolation) to trigger release of a persulfide from a small molecule, polymeric, or peptide-based prodrug platform. Importantly, the first self-immolative small molecule persulfide prodrug (termed …