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Showing 1 to 2 of 2 for “"1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore"”.
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INVESTIGATION OF SOME MOLECULAR MECHANISMS OF CYTOTOXIC 1,5-DIARYL-3-OXO-1,4-PENTADIENES
… cancer cell lines. These compounds possess a 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore. In the present study some investigations as to the way in which cytotoxicity is mediated was undertaken. Our results have demonstrated that the analogs NC 2067 and NC 2081 behaved as substrates for GSTπ …
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Synthesis and bioactivities of novel N¹-acylhydrazides
… of curcumin led to the development of the 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore and its importance in displaying antineoplastic properties has been demonstrated by our laboratory. In light of this concept, this thesis focuses on the design and development of novel …