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Showing 1 to 16 of 16 for “"1,4-naphthoquinone"”.
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Lewis Base Promoted Annulations of Allenoates with 1,4-Naphthoquinones
… easy to obtain starting materials such as 1,4-naphthoquinone is a significant goal of this project. Current research has been focused on cyclizing 1,4-naphthoquinone with varying allenoate substituents using triphenylphosphine as the Lewis base. This method has proven successful with yields up …
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Synthesis and characterization of molecules for electron transfer research.
… -(1,4-dimethoxynaphthyl)bromocyclohexane, was 1,4-naphthoquinone. After methylation and bromination, the Grignard reagent of the resulting bromide was reacted with cyclohexanedione, mono ethylene ketal. The resulting alcohol was changed to the donor precursor through the following functional group …
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Aspects of the chemistry of 1,4-naphthoquinones. An investigation of nucleophilic substitution reactions of alkylamines and hydroxyalyklamines on 1,4 napthoquinones and the role of solvent on the position of substitution.
… and hydroxyalkylamines with 5-substituted-1,4-naphthoquinones have been studied. It has been found that the nature of the solvent employed in the reaction influences the position of mono-substitution at either the 2- or 3-position. Although both regioisomers were produced in all the reactions, …
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The synthesis of derivatives of naturally occurring naphthalenes
… and efficient synthesis of a substituted 1,4-naphthoquinone which would function as a model for the naphthoquinonoid nucleus of the rifamycin subclass of these antibiotics. In this synthesis, 1,4-benzoquinone was converted into 8- …
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Rethinking the dithiothreitol based PM oxidative potential: measuring DTT consumption versus ROS generation
… (9,10-phenanthrenequinone, 5-hydroxy-1,4-naphthoquinone, 1,2-naphthoquinone, 1,4-naphthoquinone) were tested to study the pattern of the generation of •OH. Metals such as copper(II), Manganese(II) and iron (II) which exist in the ambient particulate matter abundantly were also examined in …
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Targeting isoprenoid and quinone biosynthesis for antimicrobial discovery
… which uses a novel substrate, 6-carboxy-1,4-naphthoquinone as an intermediate in the menaquinone biosynthesis. We report the first expression and characterization of H. pylori UbiD and UbiX. We demonstrate that UbiD is the menaquinone decarboxylase that is dependent on a prenyltransferase …
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Green Photochemistry: The synthesis of fine chemicals with sunlight
… the optimisation of juglone (5-hydroxy-1,4-naphthoquinone) synthesis under green conditions, the extension of the optimised procedure to a library of 1-naphthols and the investigation of photooxygenation reactions in alternative media. The dye-sensitised photooxygenation of …
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Single and hybrid antimalarials based on artemisinin, chloroquine and ß-lactams : synthesis, antiplasmodial activity, cytotoxicity and effect of selected artemisinin-chloroquine hybrids on the parasitic endocytosis pathway
… were hybridized with artemisinin or 1,4-naphthoquinone derivatives; selected hybrids were further investigated for their effect on the parasitic endocytosis pathway and compared to the effect of chloroquine and artemisinin on the same pathway. The effects of drug treatment on the …
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Isolation and Structure Elucidation of Anticancer and Antimalarial Natural Products
… (Asteraceae); one new antiproliferative 1,4-naphthoquinone, one known antiproliferative isoflovonoid, and five known antiproliferative stilbenoids from Stuhlmannia moavi (Leguminosae); four known antiproliferative bisbenzylisoquinoline alkaloids from Anisocycla grandidieri (Menispermaceae); …
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The syntheses of some naturally derived naphthoquinones
… 8-acetyl-3-acetylamino-5,7-dihydroxy-1,4-naphthoquinone from benzoquinone by means of simple reactions including, Diels-Alder adduct formation, mild acetylation, oxime formation and Beckmann rearrangement in five steps with an overall yield of 22% is described in Chapter 1. The synthesis …
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Studies of quinone monooximes derived from dihydroxyphenylalanines
… 1,6-dihydroxynaphthalene afforded 6-hydroxy-1,2-naphthoquinone 2-oxime as the main product together with some 6-hydroxy1,4-naphthoquinone 4-oxime as the 4-nitrosated compound, which were separated by using the chelating technique. For the 1,5- and 2,7-dihydroxynaphthalenes only one product …
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Synthesis, characterisation and application of novel quinones for the detection of latent fingermarks
… Recent research into the use of 2‐hydroxy‐1,4‐naphthoquinone (lawsone) has shown promising results for the development of latent fingermarks on porous surfaces. One of the aims of this thesis was to determine the reaction products between lawsone and three amino acids. These products were …
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Total Synthesis of the Unique Pederin Family Member Psymberin & Chemical Studies Toward Saliniketal Family Members: Saliniketal a, Salinisporamycin and Rifsaliniketal
… For salinisporamycin and rifsaliniketal, the 1,4-naphthoquinone skeleton was assembled via Diels-Alder cycloaddition or benzyne cycloaddition. A peptide coupling or Buchwald C-N bond coupling at a late stage between saliniketal A and the 1,4-naphtholene fragments followed by radical oxidation …
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Development and application of electrochemical dithiothreitol (DTT) assay for analysis of particulate matter
… to literature with a model oxidant quinone, 1,4-naphthoquinone, and trace metal, Cu(II). The assay was then applied to real exposure samples collected in Fresno, California and Honduras. Data from these samples were correlated against data obtained by the traditional DTT assay to investigate …
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Iron catalyzed C-H activation and synthesis of novel ligands
… actonitrile at ambient temperature to afford 1,4-naphthoquinone in high yield (82%). Iron-catalyzed aziridination was achieved by using iron(II) triflate (2.5 mol%), MS 4A (20 mg), 20 equivs. of styrene and 1 equiv. of [N-(p-nitrobenzenesulfonyl)imino]phenyliodinane (PhINNs) affording …
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Fermentation of vitamin K2 (menaquinone-7): Development of an optimal fermentation process to selectively enhance the production of the biologically significant all-trans isomer
… (menadione), which share a common 2-methyl-1,4-naphthoquinone moiety but differ in the structure of a lateral isoprenoid chain at the 3-position. Despite their structural similarities, all K vitamers have different pharmacokinetic properties attributable to the length and degree of saturation of …