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Showing 1 to 20 of 37 for “"1,3-dipolar cycloaddition"”.
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Damaged Collagen Detection and A Novel Approach to 1,3-Dipolar Cycloaddition Reactivity: Research at the Interface of Chemistry and Biology
… Part II Chapter 1. Acceleration of 1,3-Dipolar Cycloadditions by Integration of Strain and Electronic-Tuning. The 1,3-dipolar cycloaddition between azides and alkynes is enabling new means to probe and control biological processes. A major challenge is to achieve high reaction rates with …
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Interfacial Nitrone 1,3-Dipolar Cycloadditions for Modification of Monolayer Protected Gold Nanoparticles
… as a template and its ability to undergo the 1,3-dipolar cycloaddition reaction with a series of nitrones under ambient and high-pressure conditions. Expanding the scope of this reaction to the investigation in synthesizing a nitrone modified-MPN and examine its ability to undergo the 1,3-dipolar …
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Cross-Linked Polybenzyl Ether and Polyglycerol Dendrimers for Monomolecular Imprinting
… alkyne groups using copper-catalyzed 1,3-dipolar cycloaddition. The glycoside dendrimers displayed chiral activity that increased after the dendrimers were cross-linked. However, after core removal the dendrimers were optically inactive.
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Efforts Toward the Total Synthesis of Asparagamine A
… utilizes an intramolecular azomethine ylide 1,3-dipolar cycloaddition reaction as the key step. Generation of the azomethine ylide species is achieved via sequential vinylogous amide O-sulfonylation and desilylation. Several strategies designed to construct the fully oxygenated …
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Asymmetric Total Synthesis of (+)-Nominine: Development of a Dual Cycloaddition Strategy for the Synthesis of the Hetisine Alkaloids
A dual cycloaddition strategy for the synthesis of the hetisine alkaloids has been developed and applied to the asymmetric total synthesis of nominine. The approach relies on an early stage intramolecular aza-1,3-dipolar cycloaddition of a 4-oxidoisoquinolinium betaine with an ene-nitrile …
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ΜΕΛΕΤΗ ΑΝΤΙΔΡΑΣΕΩΝ ΠΡΟΣΘΗΚΗΣ ΠΥΡΑΖΟΛΙΚΩΝ ΣΥΣΤΗΜΑΤΩΝ ΜΕ 1, 3-ΔΙΠΟΛΑ ΚΑΙ ΚΕΤΕΝΕΣ
… AND NITRILIMINES UNDERGO STEREOSELECTIVELY 1,3-DIPOLAR CYCLOADDITION, IN PRESENCE OF DIPHENYLNETENE THE CORRESPONDING 1-DIPHENYL-ACETYL (3,3-DIPHENYL- 2-AROGLOXY-2-PROPENYYL)-4,4 DIMETHYL-S-METHYLENE-1H PYRAZOLES. AROMATIC TRIMETHYL-PYRAZOLES IN PRESENCE OF NITRILOXIDES UNDERGO AN ELECTROPHILIC …
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Lewis acid catalysis in organic synthesis
… catalytic system has been developed for 1,3-dipolar cycloaddition of azides to terminal alkynes using CuCl-RTIL. This catalytical system gives only 1,4-disubstituted 1,2,3-triazoles. Reactions of Alkyl and aryl azides with a variety of terminal alkynes were successfully catalyzed using …
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Neue heterocyclische Sulfoximine
… and were used as substrates in Huisgen-1,3-dipolar cycloaddition reactions with organic azides. The corresponding sulfoximidoyl-1,2,3-triazoles were obtained in yields up to 73%. The regioselectivities were examined by use of 1H-NOESY-spectroscopy. It became apparent that only …
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Kinetics of Polymer Interfacial Reactions
… 5-chloro-pentyne to form triazoles via a 1,3-dipolar cycloaddition reaction. Time-resolved ATR-IR measurements indicate that the interfacial click reaction is initially first order in azide concentration, and then transitions to apparent second order dependence, when the surface azide and …
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Synthesis and evaluation of polystyrene based soluble polymeric supports for organic synthesis
… The target compounds were synthesized via 1,3-dipolar cycloaddition reactions between polymer bound alkenes and nitrile oxides generated in situ from their corresponding aldoximes. The cleaved ?2-isoxazoline compounds were tested for biological activity against Mycobacterium fortuitum. To …
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Total Synthesis of Apratoxin A Analogues
… The azide has been successfully used in a 1,3-dipolar cycloaddition with a biotinylated alkyne, which will be assayed to help determine the molecular targets of apratoxin A. Furthermore, the polyethylene glycol azide provides us with a handle to install additional biological tags.
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Synthesis and Properties of Chemically Modified Carbon Nanotubes
… using pyridine diazonium salt addition, 1,3-dipolar cycloaddition and reductive alkylation. The selectivitiy of the addition was probed by UV-vis-NIR and Raman spectroscopy where the metallic were found to be more selective than semiconducting SWNTs. The location and distribution of the …
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From the Making to the Tuning to the Use of Chlorins for Biomedical Applications
… free base of a pyrrolidine ring form from a 1,3-dipolar cycloaddition. This strategy allows rapid conjugation to biological and biotargeting motifs. As a demonstration, the soluble chlorin platforms were conjugated to lysozyme and to an amino terminated tether on a short oligonucleotide. These …
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Design and synthesis of cyclometalated transition metal complexes as functional phosphorescent materials
… and tolerant nature of the copper mediated 1,3-dipolar cycloaddition reactions offers great flexibility in the molecular design. Chapter 1 and Chapter 2 focus on the synthesis of heteroleptic cyclometalated Ir (III) and Pt(II) complexes by utilizing the Cu(I) triazolide intermediates generated …
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Polymers containing calix[4]arenes and triptycenes : new syntheses, properties and applications
… coupling and Cu(I)catalyzed Huisgen 1,3-dipolar cycloaddition, are also investigated but found to be inferior to the acetylenic coupling polymerization. In Chapter 3, main-chain calix[4]arene elastomers are achieved by metathesis reactions. Alkene-bridged calix[4]arene monomers are …
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Poly(LA-co-TMCC)-graft-PEG Self-assembled Polymeric Nanoparticles for Targeted Drug Delivery
… surface of the nanoparticles through Huisgen 1,3-dipolar cycloaddition reaction or Diels-Alder chemistry, respectively. The GRGDS modified nanoparticles showed specific binding affinity to rabbit corneal epithelial cells that express αvβ1 integrin receptors.
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Heterocycles in peptide chemistry
… groups has been investigated using a 1,3-dipolar cycloaddition reaction strategy. These molecules, on incorporation into a chain of amino acids, have the potential to restrict the conformational freedom of the peptide.<br></br><br></br> Cycloaddition of a nitrile oxide, derived from a …
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Site-Specific Labelling of Nucleic Acids by Catalyst-Free 1,3-Dipolar Cycloadditions
… labelling of nucleic acids by catalyst-free 1,3-dipolar cycloaddition reactions. Both nitrile oxide-alkyne cycloadditions (NOAC) and strain-promoted azide-alkyne cycloadditions (SPAAC) were explored. The possiblitity for ‘pre-synthetic’ functionalisation was demonstrated using non-nucleosidic …
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ΜΕΛΕΤΗ ΑΝΤΙΔΡΑΣΕΩΝ 1,3-ΔΙΠΟΛΙΚΗΣ ΚΥΚΛΟΠΡΟΣΘΗΚΗΣ ΣΕ ΕΤΕΡΟΚΥΚΛΙΚΑ ΣΥΣΤΗΜΑΤΑ
THE MAIN PURPOSE OF THIS WORK IS TO STUDY THE 1,3-DIPOLAR CYCLOADDITION REACTIONS TO SUBSTITUTED EXOMETHYLENE-OXAZOLONES AND THIAZOLONES AND TO EXAMINE THESE REACTIONS AS A POSSIBLE SOURCE OF HETEROCYCLIC A-AMINOACID DERIVATIVES. (Z)- AND (E)-2- PHENYL-4-ARYLIDENE-5(4H)-OXAZOLONES REACT WITH …
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Novel Routes for the Design of Poly((meth)acrylic acid) Containing Polymer Structures by Controlled Radical Polymerization
… popularized copper(I) catalyzed “click” 1,3-dipolar cycloaddition reaction of azides and terminal alkynes was evaluated as a method to synthesize amphiphilic copolymer structures, using a modular approach.
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