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Showing 1 to 7 of 7 for “"1,3-Amino alcohols"”.
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Asymmetric Synthesis of 1,3-Amino Alcohols and Tropinone Derivatives From Enantiopure Sulfinimines
… of piperidine-containing syn and anti 1,3-amino alcohols as well as tropinone and tropane-containing derivatives using sulfinimines (N-sulfinyl imines) as precursors for acid-catalyzed cascade cyclizations. Chiral N-sulfinyl b-amino ketones derived from N-sulfinyl b-amino Weinreb amides, …
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New methods for the asymmetric synthesis of α-alkylated ketones and 1,3-amino alcohols
… an imine derivative for the preparation of 1,3-aminoalcohol precursors. 1,3-Aminoalcohols can be synthesised via indirect routes involving various permutations of stepwise construction with asymmetric induction. Our approach offers an alternative highly diastereomeric route to the synthesis of …
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Studies in asymmetric synthesis I the asymmetric alpha-alkylation of N,N-dimethylhydrazones II the synthesis of 1,3-amino alcohols via the aldol-Tishchenko reaction
… of non chiral azaenolates. Part II The 1,3-amino alcohol moiety is present in many molecules of pharmaceutical and biological interest with examples found consistently throughout the literature both as chiral ligands and key synthetic intermediates for biologically active natural products. …
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Allylic C—H activation to access anti-1,3-amino alcohol motifs
1,3-Amino alcohols are common motifs in a variety of biologically active molecules including antivirals, antibiotics, antifungals, and various alkaloids. Due to their prevalence and utility as synthetic intermediates, a variety of methods have been developed to access these motifs in a …
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Diastereoselectivity of the metallo-enamine condensation; addition and cyclization reactions of vinyl isocyanates
… alkoxide was developed as a way to prepare 1,3-amino alcohols and to avoid the risk of epimerization of the hydroxy imines. The use of other metals was examined. Titanium provided high levels of syn selectivity in all reactions ($<$10:90 in most cases), regardless of the size of the substituents …
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Studies in asymmetric synthesis: I. the asymmetric α-alkylation of N,N-dimethylhydrazones II. the asymmetric aldol-Tishchenko reaction of (S)-tert-butanesulfinyl imines for the introduction of 2, 3, 4 and 5 new chiral centres in one pot
… and diastereoselective synthesis of anti-1,3-amino alcohol derivatives using an aldol-Tishchenko reaction. A range of acetophenone and propiophenone derived anti-1,3 amino alcohols was synthesised using N-tert-butanesulfinyl imines. A number of potential aldol acceptors including aldimines and …
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New frontiers in allylic C––H amination via palladium/sulfoxideoxazoline catalysis
… that enables unprecedented access to anti-1,3 amino alcohols in good yields (33 substrates, avg. 66%) and high selectivities (avg. 10:1 dr). Switching ligand to (±)-CF3-SOX using a less bulky quinone oxidant (BQ), the kinetic syn- 1,3 amino alcohol motif can be accessed in comparable yields and …