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Showing 1 to 8 of 8 for “"파울러자유아메바"”.
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Production and characterization of monoclonal antibodies against cathepsin B and cathepsin B-Like proteins of Naegleria fowleri
파울러자유아메바(Naegleria fowleri)는 원발성 아메바성 수막뇌염(primary amoebic meningoencephalitis; PAM)을 일으키는 병원체이다. 파울러자유아메바의 사람이나 실험 동물에 감염은 아메바가 오염된 물에서 물놀이 혹은 수중활동을 할 때 비강내로 아메바 영양형이 유입될 때 일어난다. 파울러자유아메바의 병인기전으로는 숙주세포와 접촉하여 사멸에 이르게 하는 접촉성 병인기작과 여러가지 단백분해효소를 분비하여 숙주세포에 영향을 주는 비접촉성 병인기작으로 알려져 있다. 파울러자유아메바의 시스테인 …
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Expression of inflammasome-related molecules from U87MG cells cocultured with Naegleria fowleri in the non-contact system
Naegleria fowleri, a free living amoeba widespread in moist soil, water and sediment, exist as a virulent pathogen causing fetal primary amoebic meningoencephalitis (PAM) in experimental animals and in humam. Inflammasomes are large intracellular multiprotein complexes that play a central role in …
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Production and Characterization of Monoclonal Antibodies against a Recombinant Nfa1 Protein Cloned from Pathogenic Naegleria fowleri
OBJECTIVE: In order to use in the immunopathological studies of pathogenic Naegleria fowleri, monoclonal antibodies against a recombinant His-tag fusion Nfa1 protein cloned from pathogenic N. fowleri were produced, and its characterization was elucidated. In addition, to observe the usage in …
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Characterization of an nf-actin gene in the pathogenic Naegleria fowleri
Naegleria fowleri, a pathogenic free-living amoeba has been isolated from samples obtatined from soil,polluted water and chlorinated swimming pool waster and existed as a virulent pathogen which causes fatal primary amoebic meningoencephalitis (PAM) in experimental animal or humans. The …
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The effect of nfa1 accination against Naeglearia fowleri infection
The pathogenic free-living amoeba, Naegleria fowleri, causes fatal primary amoebic meningoencephalitis in experimental animals and in humans. The nfa1 gene that is cloned from N. fowleri is located on pseudopodia, especially amoebic food-cups and plays an important role in the pathogenesis of N. …
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Inflammasome activation in THP-1 target cells triggered by pathogenic Naegleria fowleri
Naegleria fowleri, also known as the brain-eating amoeba, causes acute primary amoebic meningoencephalitis. During swimming and other recreational water activities, N. fowleri trophozoites penetrate the nasal mucosa and invade the olfactory bulbs, resulting in intense inflammatory reactions in the …
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Cytopathic Effects of a Pathogenic Naegleria fowleri and an Anti-Nfa1 Antibody on Rat Microglial Cells
Naegleria fowleri, a free-living amoeba, causes fatal primary amoebic meningoencephalitis (PAME) in experimental animals and humans. On the pathogenic mechanisms of N. fowleri concerned with host tissue invasion, the adherence of amoeba to host cells is most important. The nfa1 gene (360 bp) was …
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Characterization of cathepsin B cysteine protease from Naegleria fowleri excretory-secretory proteins exerting immunomodulatory effects
Naegleria fowleri, a free-living amoeba that is found in diverse environmental habitats, can cause an acute fulminating hemorrhagic meningoencephalitis, called primary amoebic meningoencephalitis (PAM) in experimental animals and in humans. Pathogenicity of N. fowleri may be induced by …