Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"천식"”.
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TDI 천식 기도염증반응과 관련된 활성산소의 역할
ABSTRACT .i TABLE OF CONTENTS v LIST OF FIGURES viii ABBREVIATIONS x I.INTRODUCTION 1 II. MATERIALS AND METHODS 7 A. Method 7 1. Epithelial cell culture and tTG activity assay 7 2. Intracellular reactive oxygen species (ROS) measurement 8 3. Immunoblot analysis 8 4. In vitro cross-linking reaction …
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Development and characterization of recombinant human autoantibody using cDNA made from peripheral blood mononuclear cells of patients with bronchial asthma
… 재료 및 방법 3 A. 대상 환자의 선별 및 채혈 3 1. 대상 환자 및 비알레르기성 천식의 임상적인 중증도 분류 3 B. 비알레르기성 천식 환자들의 말초혈액으로부터 total RNA 추출 3 1. 말초혈액 단핵구 세포 (peripheral blood mononuclear cell, PBMC) 분리 3 2. Total RNA 추출 4 3. mRNA 분리 4 C. Polymerase chain reaction (PCR)을 이용한 cytokeratin 18 (CK-18) 단백질에 대한 인간 single-chain variable …
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Genome-wide Association Study of TDI-Induced Asthma in a Korean Population : Signofocant Association of a T-catenin(CTNNA3) and TRP channel gene-gene interaction
"연구목적: Affymetrix 500K 유전자칩을 이용하여 TDI 천식환자와 정상인 간의 전체 게놈 연관성 연구 (genome-wide association study)를 진행하여 TDI 천식의 병인기전에 관여하는 유전적 변이를 찾아보고 유의한 의미를 가지는 유전적 변이에 대해 유전자-유전자 (gene-gene) 상호작용 분석을 통하여 유전적 변이간의 관계를 알아보고자 한다. 연구방법: 직업성 천식인 TDI천식 환자 84명과 건강한 정상인 263명에 대하여 Affymetrix 500K 유전자칩을 사용하여 대량의 유전적 변이들의 …
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EpitopeAnalysisofCytokeratin 18Protein binding withAutoantibodiesin SeraofPatientswith NonallergicAsthma.
PURPOSE: Recently autoantibodies to bronchial epithelial proteins were detected in sera of patients with nonallergic asthma and cytokeratin 18 (CK18) protein was identified as an autoantigen associated with nonallergic asthma. In this study, epitope of CK18 protein binding with autoantibodies in …
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Autoantibodies From Patients With Nonallergic Asthma Cause Cytotoxic Injury To Airway Epithelial Cells.
RATIONALE: Increased levels of IgG autoantibodies to airway epithelial cells in serum samples of nonallergic asthma compared to allergic asthma and healthy controls have been reported. And a possible involvement of autoimmune response against bronchial epithelial cell antigen in the pathogenesis of …
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Soluble C-Kit Receptor Level May Be a Serological Marker for Predicting the Extent of Upper and Lower Airway Inflammation
BACKGROUND: It is known that allergic rhinitis could progress to asthma. Both allergic rhinitis and asthma are characterized by a Th2-dependent inflammation composing activated mast cells and eosinophils. Mast cell development and survival is dependent on the Kit-mediated activation and this stem …
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Serum Specific IgG to Cytokeratin : A Useful Serologic Marker for Toluene Diisocyanate-Induced Asthma
PURPOSE: Although specific IgE and IgG to isocyanate-HSA conjugate has been used to predict specific bronchoprovocation test results, they are not sensitive enough for the diagnosis of patients with toluene diisocyanate (TDI)-induced asthma. We evaluate the clinical significance of specific IgG to …
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Genetic Effect of ALOX15 Polymorphisms on Aspirin-Exacerbated Respiratory Disease
BACKGROUND AND OBJECTIVE: The 15(s)-hydroxyeicosatetraenoic acid (15(s)-HETE), a major metabolite of 15-lipoxygenase (15-LO) pathway, has been suggested to contribute to asthma pathogenesis. Elevated levels of 15(s)-HETE in bronchoalveolar lavage fluid (BALF) were demonstrated in severe asthmatics …
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Role of Chitinase in the development of work-related symptoms in bakery workers
… 면역세포로부터 Chitinase 생성이 증가하면서 유도되는 기도 염증 반응이 제빵공 천식의 병인 기전에 관여하리라 추정하고 있지만, 아직 그 기전은 알려져 있지 않다. 본 연구에서는 제빵공에서 밀가루 분진 노출후 Chitinase 생성 증가가 작업 관련 증상 발생에 관여할 가능성을 탐색하였다. 성남의 한 제빵공장 직원 381명을 대상으로 하였고, 이들은 분진에 노출되지 않은 건강 대조군 106명과 비교하였다. 제빵공의 작업 관련 증상 유무를 판정하기 위해 설문지 조사를 시행하였고, 밀가루 항원에 감작 유무와 아토피 유무는 …
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Analysis of the Repeated Measurement Data using the Hierarchical Clustering and Nonlinear Regression Methods in Asthma Pharmacogenetic Study
OBJECTIVE: We examined several analytic methods for predicting therapeutic response to drug in Korea asthmatics and tried to develop a clinical model to predict the drug response to asthma drug. BACKGROUND: Long acting β2-agonists (LABA) is the most powerful bronchodilator and inhaled …