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Showing 1 to 3 of 3 for “"원발성 아메바성 수막뇌염"”.
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Production and characterization of monoclonal antibodies against cathepsin B and cathepsin B-Like proteins of Naegleria fowleri
파울러자유아메바(Naegleria fowleri)는 원발성 아메바성 수막뇌염(primary amoebic meningoencephalitis; PAM)을 일으키는 병원체이다. 파울러자유아메바의 사람이나 실험 동물에 감염은 아메바가 오염된 물에서 물놀이 혹은 수중활동을 할 때 비강내로 아메바 영양형이 유입될 때 일어난다. 파울러자유아메바의 병인기전으로는 숙주세포와 접촉하여 사멸에 이르게 하는 접촉성 병인기작과 여러가지 단백분해효소를 분비하여 숙주세포에 영향을 주는 비접촉성 병인기작으로 알려져 있다. 파울러자유아메바의 시스테인 …
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Production and Characterization of Monoclonal Antibodies against a Recombinant Nfa1 Protein Cloned from Pathogenic Naegleria fowleri
OBJECTIVE: In order to use in the immunopathological studies of pathogenic Naegleria fowleri, monoclonal antibodies against a recombinant His-tag fusion Nfa1 protein cloned from pathogenic N. fowleri were produced, and its characterization was elucidated. In addition, to observe the usage in …
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Cytopathic Effects of a Pathogenic Naegleria fowleri and an Anti-Nfa1 Antibody on Rat Microglial Cells
Naegleria fowleri, a free-living amoeba, causes fatal primary amoebic meningoencephalitis (PAME) in experimental animals and humans. On the pathogenic mechanisms of N. fowleri concerned with host tissue invasion, the adherence of amoeba to host cells is most important. The nfa1 gene (360 bp) was …