Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"억제제"”.
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Effects of Cadmium on VCAM-1 Expression
… 발현변화가 어떤 세포신호체계를 경유하는지를 알아보기 위해 신호전달물질인 MAPK의 억제제를 사용한 결과, p38 MAPK 억제제 (SB202190)와 JNK 억제제 (SP600125)는 VCAM-1의 발현증가를 억제시킨 반면, ERK 억제제 (U0126)는 발현증가에 아무런 영향을 미치지 못하였다. 이 결과로 보아 카드뮴은 p38 MAPK와 JNK의 인산화를 경유하여 뇌혈관 내피세포의 VCAM-1의 발현을 증가시키는 것으로 생각된다. "
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Dysfunction of Pancreatic INS-1 Beta-Cells Induced by Chronic Exposure to High Glucose
… 어떤 것인지를 확인하였다. 또한 이러한 현상과 관련된 기작을 찾기 위해 다양한 대사 억제제 및 신호전달 억제제를 사용하여 고농도 포도당의 지속적인 노출에 의해 감소된 프로모터 활성이 회복되는 지를 조사하였다. 결과: INS-1 세포에서 고농도 포도당의 지속적인 노출에 의해 인슐린과 pdx-1 유전자 발현이 포도당 농도 의존적이고 시간 의존적으로 감소하는 현상을 관찰하였다. 또한 이렇게 감소된 인슐린과 pdx-1 mRNA는 5 mM 포도당에 다시 배양할 경우, 발현이 회복되는 가역적 반응을 나타내었다. PDX-1을 과발현시킬 …
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Coronavirus Replication Inhibition by Herbal Extracts
Coronaviruses are plus-stranded RNA viruses that infect human and large variety of animals, including pig, cattle, dog, rat, rabbit, turkey, and bird. Human coronavirus has been known to cause common colds and perhaps gastroenteritis. Animal coronaviruses cause gastroenteritis, hepatitis, and a …
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Effects of loigomycin, F0/F1 ATP-synthase inhibitor on mitochondrial morphology and dynamics
Mitochondrial fission has recently been well-recognized as a factor involved in apoptosis although its role and the underlying mechanism remains unclear. Recently, we monitored the effects of mitochondrial respiratory inhibitors [rotenone, TTFA (2-thenoyltrifluoro-acetone), antimycin A, and …
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The Effect of Withdrawal of Angiotensin II Blockers on Serum Creatinine and Potassium in Patients with Chronic Kidney Disease
BACKGROUND: Renin-angiotensin system (RAS) blockers have been used to delay the progression of various renal diseases, but these medications cause hyperkalemia and the elevation of serum creatinine which impede the continuation of the medications. So far, there have been no data which observe the …
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Enhancement of Antitumor Activities of a Selective Cyclooxygenase-2 Inhibitor, Celecoxib on the Lewis Lung Carcinoma that Express Cyclooxygenase-2
COX-2 promotes carcinogenesis, tumor proliferation and growth, angiogenesis, prevention of apoptosis, immunosuppression. Selective inhibition of COX-2 activity in several animal models is associated with decrease in new vessel production in tumors, decreases in new vessel formation, and increases …
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Mesenchymal Stem Cells Therapy in Progressive Rat Model of Parkinson's Disease
Parkinson’s disease (PD) is a common progressive neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra (SN). In present study, we investigated the effect of human mesenchymal stem cells (hMSCs) therapy in vitro and progressive SD rat model of PD using MG-132, …