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Showing 1 to 3 of 3 for “"악성화"”.
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Studies on the Mechanisms of Malignant Transformation in Neurofibromatosis Type 1
… peripheral nerve sheath tumors(MPNSTs)로 악성화 된다고 알려져 있다. NF1은 높은 발병률, 예측불허의 다양한 합병증 동반과 악성화, 임상적 증상의 다양성과 심각성, 치료방법의 부재 등으로 인해 효과적이고 근본적인 치료법에 대한 기초적, 임상적 연구가 절실히 요구되고 있다. NF1은 정상세포에서 양성종양세포, 악성종양세포로 악성화 되는 다양한 과정은 보고 되어 있으나, 아직 정확한 악성화 기전이 밝혀져 있지 않다. 본 연구는 NF1의 악성화 기전규명을 목표로 하였다. 악성종양으로 …
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Effect of mitochondrial respiratory defecton hepatocellular carcinoma :Involvement of mtOGG1 and NUPR1
Many solid tumor cells exhibit mitochondrial respiratory impairment. However, the mechanisms of such impairments in cancer development remain unclear. In this study, to investigate an effect of mitochondrial dysfunction on hepatocellular carcinoma, the two projects were studied. The first project …
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The Role of Bcl-xL and EGFR in the Malignant Progression of Neurofibromatosis type 1
Neurofibromatosis Type 1 (NF1) is one of the most commonly inherited autosomal dominant human genetic disorders, with an incidence of approximately 1 in 3000~3500 individuals worldwide. NF1 is caused by loss-of-function mutations in the NF1 gene encoding neurofibromin, a GTPase-activating protein …