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Showing 1 to 11 of 11 for “"세포사멸"”.

  1. Studies on the mechanism of insulin signaling reduction in high glucose/palmitate-induced INS-1 beta cell death

    … 의한 INS-1 베타세포 사멸 시 스트레스 신호의 영향 24 2. IKK 저해로 인한 세포사멸 억제효과 25 C. HG/PA 에 의한 세포 사멸과 inflammation 신호와의 연관 관계 35 1. IKK down stream 인 IκBα와 IκBβ, NFκB 억제가 세포사에 미 치는 영향 35 2. IKK upstream 인 NIK, TLR2, TLR4, Myd88 억제가 세포사에 미치는 영향 40 Ⅳ. 고찰 47 A. HG/PA에 의한 INS-1 베타세포의 세포사 증가 47 B. HG/PA에 의한 INS-1 세포사는 …

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  2. Regulation of Senescence Phenotypes by TIS21 gene in Huh7 Human Liver Cancer Cells

    … 중요인자이고 조혈모세포 증식억제인자로 보고된 바 있다. 이 외에도TIS21은 암 억제, 세포사멸(Apoptosis), cell cycle 조절인자, DNA 수복 조절인자, transcriptional co-regulator, 배아세포의 분화 기작 조절인자로서의 기능을 가지고 있다. 본 연구에서 주목한 TIS21의 기능은 TIS21이 cell cycle 조절인자들을 조절함으로서 세포의 노화에 관여하고 있다는 점이다. 정상 세포에서 TIS21과 동등유전자인 BTG2가 세포노화를 유도한다는 사실에 기반을 두어 암세포에서의 TIS21의 …

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  3. Development and characterization of recombinant human autoantibody using cDNA made from peripheral blood mononuclear cells of patients with bronchial asthma

    … 4. Flow cytometry 분석 15 H. IgG 자가항체의 세포독성 평가 및 세포사멸 기전 관찰 15 1. 3- (4,5-dimethylthiazol-2yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay 15 2. 사람 보체 첨가시 자가항체에 의한 세포독성의 변화 분석 16 3. Annexin V-FITC / propidium iodide (PI) assay를 이용한 세포사멸기전 분석 16 Ⅲ. 결과 18 A. 비알레르기성 천식 환자들의 말초혈액단핵구 (PBMC)로 부터 추출한 …

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  4. Studies on the Mechanisms of Malignant Transformation in Neurofibromatosis Type 1

    … actinomycin D와 etoposide를 세 가지 종류의 세포에 처리한 후 세포사멸 정도를 활성화 형태의 caspase 3를 통해 관찰한 결과, 악성종양세포로 갈수록 apoptosis에 대한 내성을 확인하였다. 따라서, apoptosis 조절에 관련하는 단백질들의 발현량을 확인한 결과, p53, Bax, Bak의 경우 발현양이 비슷하였으나, anti-apoptotic protein인 Bcl-2는 정상표현형세포에서 악성으로 갈수록 발현양이 감소되어있었고, Bcl-xL의 경우 Bcl-2와는 반대로 악성종양세포에서 …

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  5. The Role of PKC-δ in Hypoxia-induced Cerebrovascular Endothelial cell death.

    In various cell types, PKC(protein kinase C)-δ has been found to be an important mediator during hypoxia-induced cell death. However, the role of PKC-δ in cerebrovascular endothelial cells is unknown. Therefore, we investigated the role of PKC-δ during hypoxia-induced cell death using bEnd.3 cell, …

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  6. Protective effect of JAK3 inhibition on growth factor deprivation induced neural progenitor cell death

    Apoptosis is evolutionally conserved, and plays central roles during normal development of the nervous system. The number of embryonic neuroepithelial cells (NECs) is regulated by programmed cell death when NECs are substantially proliferated by growth factors(GFs). The extrinsic factors such as …

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  7. Protective Mechanism of Epigallocatechin-3-gallate against Helicobacter pylori- induced Gastric Epithelial Cytotoxicity via Blockage of TLR-4 Signaling

    Helicobacter pylori infection leads to gastric mucosal damage by several mechanisms including the direct effect of virulence factors produced by H. pylori, propagation of inflammation, oxidative stress, DNA damage, and induction of apoptosis. (-)-Epigallocatechin-3-gallate (EGCG), one of green tea …

    ajou Repository record for Protective Mechanism of Epigallocatechin-3-gallate against Helicobacter pylori- induced Gastric Epithelial Cytotoxicity via Blockage of TLR-4 Signaling (opens in a new tab)

  8. Screening of radioprotective agents using zebrafish and Therapeutic effects and protective mechanism of radioprotective candidates on radiation-induced oral mucositis

    Screening of radioprotective agents using zebrafish and Therapeutic effects and protective mechanism of radioprotective candidates on radiation-induced oral mucositis Radiation-induced oral mucositis is a dose-limiting toxic side effect for patients with head and neck cancer. About 50–90% of cancer …

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