Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"베체트병"”.
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단순포진바이러스로 유도된 베체트병 마우스모델에서 CD4+CD25+ 조절 T 세포의 역할
"ABSTRACT TABLE OF CONTENTS LIST OF FIGURE LIST OF TABLES Ⅰ. INTRODUCTION Ⅱ. MATERIALS AND METHODS A. Antibodies and reagents B. Animal experiments C. BD-like symptoms D. Flow cytometry E. Splenocyte culture and generation of Treg cells F. Dendritic cells isolation and culture G. Co-culture of …
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Expression and function of the NLRP3 inflammasome in Behçet’s disease
연구배경: 베체트병운 점막 및피부, 눈, 혈관, 신경 및 기타 여러 장기를 침범할 수 있는 임상적 특징을 가지는 만성, 재발성의 전신질환이다. 현재까지 베체트병에서 보이는 지속적인 염증 반응의 정확한 원인 기전은 밝혀져 있지 않으나 베체트병이 감염에 의해 촉발되는 자가면역 질환과 자가염증 질환의 경계선상에 있을 것이라는 주장이 제기되고 있다. 최근 그람 음성균 감염 후 발생한 구내염 환자에서 NLRP3 inflammasome를 매개로 한 전신 염증의 가능성이 보고 되고 있으나 아직까지 베체트병에서 NLRP3 …
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The role of immunosenescence in autoimmune/autoinflammatory pathogenesis of Behçet's disease
Background and objectives: Behçet’s disease (BD) is a chronic inflammatory disease characterized by recurrent mucocutaneous ulceration and complications such as blindness and large vessel inflammation. Immunosenescence, aging of immune system, is related to increased susceptibility to infectious …
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Expression of Th17 and related cytokines according to clinical activity of Behcet's disease
Background: Behçet’s disease (BD) is a multisystem inflammatory disorder characterized by recurrent oro-genital ulcers, and cutaneous, ocular, arthritics, gastrointestinal, vascular, and neurovascular involvement. The etiology and pathogenesis of BD have remained unclear, however it has been …
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Expression of Macrophage Migration Inhibitory Factor in Behçet's disease
PURPOSE: Macrophage migration inhibitory factor (MIF) is a unique protein, participating in inflammation, immune response, and cell growth. Previous reports showed that MIF-173 G>C polymorphism or the MIF-794 [CATT]5-8 polymorphism and haplotypes containing these variants were associated with an …
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cDNA microarray Analysis Identifies Symptom-Associated Chemokine Genes in Behcet's Disease Mouse Model
Behcet's disease(BD), a chronic inflammatory disease, is characterized by intraocular inflammation, oral ulcers, genital ulcers, skin lesions and additional accompanying changes. A developing aspect of BD is reached until eye symptoms are present from early mucocutaneous symptoms via arthritic and …
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MicroRNA as Regulator of the Th17 Inflammation in Behcet's disease
BACKGROUND: MicroRNAs (miRNAs) play a critical role in the regulation of host genomic expression; they are also involved in regulation of the immune response by control of target genes. Recent studies of miRNAs have revealed that aberrant expression and/or function of miRNAs in chronic inflammatory …
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Effects of Vitamin D on Expression of Toll-like Receptors of Monocytes from Patients with Behcet's Disease
PURPOSE: Behcet’s disease (BD) is a chronic, relapsing, systemic vasculitis of unknown etiology. Although the exact mechanisms of the increased inflammatory response is not yet clear, infectious agents and immunological cross-reaction with the heat-shock proteins (HSP) are considered to play roles …
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The Role of Qa-2, the Functional Homolog of HLA-G, in a Mouse Model of Behcet's Disease Induced by HSV Inoculation
HLA-G (human leukocyte antigen-G) is a nonclassical class I MHC molecule. HLA-G interacts with different natural killer (NK) cell receptors and is able to inhibit NK and T-cell cytotoxicity, as well as T-cell proliferation. An HLA-G 3741_3754 14-base pair insertion allele was significantly more …
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The role of T cell Immunoglobulin Mucin domain in Herpes Simplex Virus-induced Behçet’s Disease mouse model
The T cell immunoglobulin mucin (TIM) proteins regulate T cell activation and tolerance. Individual TIM family members may serve as susceptibility markers for asthma, allergies and autoimmune diseases, as well as potential cell surface markers for T helper type (Th)1 and Th2 T cells. TIM-1 plays an …