Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"⍺-C–H Functionalisation"”.
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Metal-free C-H functionalisation methods
… describes the development of two metal-free C–H functionalisation methods which encompass oxidations of sp³- and sp²-hybridised C–H bonds.Chapter 1 provides a brief introduction to the rapidly growing area of C–H functionalisation and outlines selected metal-catalysed and metal-free C–H …
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Direct ⍺-C–H Functionalisation of Cyclic Alkylamines
… Consequently, methods for the selective functionalisation of these scaffolds would greatly facilitate the optimisation of biological activity, physicochemical properties and the systematic evaluation of structure-activity relationships. This thesis describes efforts towards the development …
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A concise and scalable total synthesis of dictyodendrin B by sequential C–H functionalisation
… towards achieving this goal via a sequential C–H functionalisation strategy (Scheme 1). The functionalisation of C–H bonds has attracted considerable interest due to its potential impact on the synthesis of complex molecules. Our aim was to demonstrate the advantages and feasibility of performing …
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Palladium(II)-Catalysed sp 3 C–H Functionalisation of Hindered Amines and its Application in Synthesis of Astemizole Analogues
… building blocks. The sterically promoted C–H functionalisation strategy has been employed as the key step in the synthesis of a functionalised analogue of astemizole, a pharmaceutical agent which suffers from undesired hERG activity. The increased steric bulk around the tertiary amine, coupled …
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Studies in palladium and rhodium catalysis: synthetic strategies for C–C bond formation
… wellestablished conditions, which promote C−H functionalisation through Concerted MetalationDeprotonation (CMD), proved unsatisfactory for electron-rich diarylether precursors. Herein, we report a Pd-catalysed C−H functionalisation protocol that works with electron-rich arenes. We suspect that …
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Controlling Site-Selectivity in Palladium-Catalysed Cross-Coupling Reactions using Non-Covalent Interactions Between Ligand and Substrate
… used in conjunction with palladium-catalysed C-H functionalisation. Finally, by systematically changing the size of the cation and the position of the sulfonate group on the ligand scaffold, it was possible to achieve site-selective Suzuki coupling of isomeric di-, tri- and tetra-chlorinated …
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Late stage oxidative C(sp3)–H alkylation and arylation
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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Development of Ion Pairing Strategies that Utilise Cations to Control Selectivity in Transition Metal-Catalysed Functionalisation of C–H Bonds
… The formidable challenge of selective C–H bond functionalisation through transition metal catalysis offers an ideal platform to investigate the potential of invoking control through ion pairing interactions. The ion pairing strategies explored in this thesis focus on how cations may be used to …