Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"∆9-tetrahydrocannabinol (THC)"”.
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CANNABINOIDS DELTA-9-TETRAHYDROCANNABINOL (THC) AND CP55,940 ABLATE SPECIFIC CHEMOKINE AND CYTOKINE INFLAMMATORY RESPONSE IN BV-2 MOUSE MICROGLIAL CELLS ACTIVATED WITH HIV-1 PRO-INFLAMMATORY PROTEIN TAT
… was to determine whether the select cannabinoids THC and CP55,940 could ablate the inflammatory response on BV-2 mouse microglia cells caused by Tat. Within the constraints of the experiment, no major effects of cannabinoid treatment were observed at the level of the proteome as tested by …
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Detection and Imaging of Neurotransmitters in Rodent Brain Tissue Using FMP-10 and ZnO Nanoparticle Matrices with Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry
… female adolescent rats administered edible Δ-9-tetrahydrocannabinol (THC). Our MALDI MSI data revealed significant downregulation of dopamine, GABA, glutamate, and glutamine levels in the prefrontal cortex and nucleus accumbens of THC-treated males and females. To improve the quantitative …
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A COMPARISION OF DELTA-9-TETRAHYDROCANNABINOL DEPENDENCE IN C57Bl/6j MICE AND FATTY ACID AMIDE HYDROLASE KNOCK OUT MICE
… or its primary psychoactive constituent, delta-9-tetrahydrocannabinol (THC), is gaining acceptance. However, there are no currently approved pharmacotherapies to treat cannabinoid withdrawal. The objective of this thesis was to evaluate whether elevating endogenous anandamide levels using mice …
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Effects of oral delta-9-tetrahydrocannibinol (THC) administration on motor activity and anxiety-like behavior in adolescent and adult Sprague-Dawley rats of both sexes
… and its primary psychoactive component delta-9-tetrahydrocannabinol (THC) may induce modifications in neural circuitry that in turn lead to adverse consequences on behavior. Previous literature has suggested that intraperitoneal, intragastric, or subcutaneous administration of THC may produce an …
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Comparing Extraction Methods in Sample Preparation for the Quantification of Cannabinoids in Industrial Hemp
… Farm Bill) as Cannabis containing <0.3% total tetrahydrocannabinol (THC). The 2018 Farm Bill does not, however, specify standard methods for sample preparation or quantification of cannabinoids (including THC) in Cannabis. Extraction efficiency of phytochemicals is well-known to depend on the …
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Preformulation Characterization And Formulation Development of Δ9-Tetrahydrocannabinol Prodrugs For Potential Treatment Of Glacuoma
… could be linked to this observation. Delta-9-Tetrahydrocannabinol (THC) was one of the ingredients identified. However, four decades and numerous research efforts since the first observation, it has still not been concluded whether THC is effective in the treatment of glaucoma or not. Current …
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Cannabinoids and Psychosis – Cause and Treatment
… illness. The main active ingredient is Δ-9-Tetrahydrocannabinol (THC). In healthy humans, the acute administration of THC can elicit transient psychotic symptoms and cognitive impairment. THC stimulates the endocanabinoid CB1 receptor (CB1R). However, beyond CB1Rs, the mechanism underlying …
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Preparation and Characterization of Lyophilized Cyclodextrin Complexes of a Hemisuccinate Ester of Delta-9-Tetrahydrocannabinol for Transmucosal Delivery
Delta-9- Tetrahydrocannabinol (THC) is the primary active ingredient of the plant Cannabis sativa (marijuana), responsible for the majority of the pharmacological effects. The most promising clinical applications of THC approved by the Food and Drug Administration (FDA) are for the control of …
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Effect of Cannabinoids and Stress on Motor Maps and Behaviour
… The last study observed the effects of delta-9-tetrahydrocannabinol (THC) on motor map expression as well as skilled and unskilled behaviour. It was discovered that THC dose dependently affected motor map expression in that a low dose of THC increased map expression while higher doses decreased …
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Cannabinoid Modulation of Reinforcement Maintained by Stimulation of the Medial Forebrain Bundle in C57Bl/6J Mice
… agonists, including marijuana containing delta-9-tetrahydrocannabinol (THC), are found rewarding by humans. In addition to human self-reports and experimental studies that show marijuana is rewarding, contributions from preclinical studies also have implicated cannabinoid receptors in …
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Cannabinoid Modulation of Chemotaxis of Macrophages and Macrophage-like Cells
… secreted proteases. The partial agonist delta-9-tetrahydrocannabinol (THC), administered in vitro, inhibited the chemotactic response of peritoneal macrophages to the chemokine RANTES and to Acanthamoeba conditioned medium. In vivo treatment with THC also resulted in inhibition of the in vitro …
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Antimicrobial Activity of Cannabis Extraction Products and Terpenes against Foodborne Pathogens And Use of Electrochemically Activated (ECA) Water for Control of Indoor Mold in a Cannabis Production Facility
… than 0.3% of Delta 9 – Tetra Hydro Cannabinoid (THC).By definition, Cannabis sativa plants that produce less than 0.3% in dry weight of delta-9- – tetrahydrocannabinol (THC) are classified as hemp. Hemp plants are also known for producing larger amounts of cannabidiol (CBD). Hemp is grown …
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Genetic Variation and Sex Mediate Differential Responses to ∆-9-tetrahydrocannabinol among Inbred Mice
… and later isolated. In the 1970’s, ∆9-tetrahydrocannabinol (THC) was isolated and recognized as the major constituent responsible for the psychoactive and intoxicating effects associated with consumption of cannabis. This opened the door for intensive research in the field that lead to …
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Effects of alcohol and ∆9-tetrahydrocannabinol on energy balance and cognitive behaviors
… to overweight and obesity is debatable. ∆9-tetrahydrocannabinol (THC), the main psychoactive constitute of marijuana, mainly activates cannabinoid subtype 1 and 2 receptors (CB1R and CB2R) to modulate many behavioral and metabolic processes, including feeding and glucose homeostasis. For …
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The Effects of Cannabis sativa on the Sperm Epigenome
… cannabis use in humans, and exposure to delta-9-tetrahydrocannabinol (THC, the main psychoactive component of cannabis) in rats, is associated with significantly altered levels of DNA methylation in sperm. Epidemiological studies have further associated prenatal cannabis use with an increased …