Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"γ-irradiation"”.
-
UHRF1 and the DNA Damage Response
… response to DNA damage caused by exposure to γ-irradiation. Our findings for chapter three indicate that (i) UHRF1 is crucial for the cellular iii response to double strand breaks caused by γ-irradiation and that (ii) UHRF1 is critical for maintenance of chromosome integrity. Recent studies have …
-
Sterility and immunogenicity of gamma-irradiated respiratory viruses
… not be reliable or applicable to estimate the irradiation dose required to sterilise microbiological preparations for vaccine purposes, where bioburden is deliberately high. In this study, I investigated different methods of modelling sterility and developed a new formula for calculating …
-
Modulation of Clr-b Ligand for the Inhibitory NKR-P1B NK Cell Receptor in Response to Transformation and Genotoxic Stress
… of genotoxic agents with the exception of γ-irradiation and radiomimetics. The loss of surface Clr-b results in disinhibition of target cells using 51Cr-release assays and BWZ reporter assays. ii In the next chapter, we investigate the mechanism(s) by which this phenotype occurs. Genotoxic …
-
The Role of Receptor Tyrosine Kinase Axl In Pancreatic Ductal Adenocarcinoma and Its Regulation By Hematopoietic Progenitor Kinase 1
… PDA cells to apoptosis stimuli such as γ-irradiation and serum starvation. In addition, we found that Axl-mediated Akt and NF-κB activation and up regulation of MMP2 were involved in the invasion, migration and survival of PDA cells. Thus, we demonstrate that Axl plays an important role in …
-
Mid-IR Imaging and Multivariate Analysis of Dynamic Processes in Pharmaceutically Relevant Microparticles
… in Mw of all of the component polymers post γ irradiation indicating a chain scission mechanism as studied by GPC and DSC; and (iv) the increase in the number of oxygenated components in the Poloxamer 407 excipient, thereby increasing the strength of interaction between the microparticle and …
-
Evaluation of γ-Irradiated Peanut Extract as a Proper Immunogen for Immunotherapy in Murine Model of Peanut Allergy
… of IgE-mediated food hypersensitivity, and gamma irradiation has been applied widely for the preservation of food. Previous studies indicated that the capacity of IgE to binds to ovalbumin (OVA) and ovamucoid (OM) was profoundly reduced after treatment with a combination of gamma irradiation and …