Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"γ-aminobutyric acid"”.
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Synthesis and evaluation of β-fluoro-γ-aminobutyric acid enantiomers
… from phenylalanine indicated that amino acids are practical starting materials for the preparation of β-fluoroamines. This methodology is applied to L-lysine to generate (2R)-fluorohexane-1,6-diamine. The formation of a diamine of potential interest for catalysis is also observed in this …
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Alcohol alters the expression of Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptors (SNAREs) and spontaneous γ-Aminobutyric Acid (GABA) release...
… We found that alcohol increased gamma-aminobutyric acid (GABA) release via HSF1, but had no effect on glutamatergic synaptic vesicle fusion. Collectively, these data indicate that alcohol induction of HSF1 transcriptional activity triggers a specific coordinated adaptation in GABAergic …
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Detection and Imaging of Neurotransmitters in Rodent Brain Tissue Using FMP-10 and ZnO Nanoparticle Matrices with Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry
… to detect 17 neurochemicals, notably dopamine, γ-aminobutyric acid (GABA), serotonin, and norepinephrine. ZnO NP detects 9 neurochemicals, including glutamate and glutamine, which are undetectable by FMP-10. We applied both matrices to investigate neurochemical changes in male and female …
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Investigation into the role of binding loop E on the function of the nematode cys-loop GABA receptor.
… pocket in Hco-UNC-49BC, the LGCC gated by γ- aminobutyric acid (GABA) within H. contortus. To meet this objective, each amino acid residue in binding loop E was changed to a cysteine and analyzed via electrophysiology and the substituted cysteine accessibility method. It was found that of the …
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Investigation of an unusual GABA-A receptor: studies on the promiscuous ε [epsilon] subunit
γ-aminobutyric acid (GABA) type A (GABAA) receptors are pentameric, chloride-selective ion channels. Nineteen different GABAA receptor subunits are known to exist in man and various subunit combinations are able to form receptor subtypes with different, subunit-specific pharmacological properties. …
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Expression of GABAA receptor subunit genes in the avian song system and their role in learning and memory
γ-aminobutyric acid type A (GABAA) receptors are the primary mediators of inhibitory neurotransmission in the brain. In avian systems, 14 GABAA receptor subunits (α1-6; β2-β4; γ1, 2 and 4, δ and π) have been identified. These assemble into pentameric transmembrane structures with an intrinsic …
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High frequency activity preceding epileptic seizures
… transmission through glutamatergic and γ-aminobutyric acid-ergic synapses were not essential in HFA formation but they were related to the modulations of HFA. Our findings suggested the crucial role of HFA in the seizure genesis and the potential value in seizure prediction by monitoring …
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Understanding the Mechanisms of Motor Learning in the Vestibulo-ocular Reflex
… glutamate receptors (mGluR1) and B type γ-aminobutyric acid (GABAB) receptors. Blocking one or both of these receptors with an antagonist inverts gain-up learning, while the agonist augments gain-up learning. Furthermore, we provide novel evidence that these receptors are co-activated …
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Examination of intramolecular interactions between residues of the cys-loop GABA receptor Hco-UNC-49 from Haemonchus contortus
… Hco-UNC-49 is unique parasitic nematode γ-aminobutyric acid (GABA) gated chloride channel that may prove to be a novel drug target. The objective of this thesis was to characterize intramolecular interactions of Hco-UNC-49B. Two sets of oppositely charged residues were chosen based on their …
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Discovery of Novel Neurologically Active Phytochemicals in Neotropical Piperaceae: An Ethnopharmacological Approach
… the extracts’ in vitro activity on the γ-aminobutyric acid (GABA) system. Plant extracts in general demonstrated moderate to high affinity to the GABA-BZD receptor. Additionally, extracts demonstrated low to moderate activity in the inhibition of the GABA-T enzyme, with a few plants …
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Πορείες συνθέσεως ενώσεων με βιολογικό ενδιαφέρον από 2Η-πυραν-3(6Η)-όνες
… materials. ii) The synthesis of sugaryl-aminoacids (which may be considered as a new class of compounds of pharmacological interest), by Michael addition of aminoacids to 2H-pyran3(6H)-ones and subsequent reduction of the carbonyl group, as well as the stereochemical aspects of the addition. …
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Study of visual field defects in patients with epilepsy receiving Vigabatrin
Vigabatrin, a GABA (γ-aminobutyric acid) agonist is a drug widely prescribed in Europe and Asia between 1989 and 1997 for drug resistant, partial epilepsy and has been associated with visual field defects. Uncertainity in the effect of Vigabatrin on vision resulted in decreased prescriptions. …
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Investigating excitatory GABAergic signalling & benzodiazepine resistance in an in vitro model of status epilepticus
… neurotransmitter within the brain, gamma (γ)-aminobutyric acid (GABA). In a subset of patients however, benzodiazepines prove to be ineffective in terminating SE. Previous data from in vitro models has demonstrated that during single seizures, instead of being inhibitory, activation of the …
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Evaluating the impact of heat stress and altered glycemic state on plasma ɣ-Aminobutyric Acid (GABA) in lactating Holstein cows
… in lactating dairy cows. We hypothesized that γ-aminobutyric acid (GABA) participates in the regulation of this altered glycemic state as it is produced by the pancreatic beta cells and has a stimulatory effect on pancreatic secretion of insulin. Multiparous lactating Holstein cows (n=6; …
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Anomalies of GABAergic system associated with HIV-1 infection
… Findings of lowered concentrations of γ-Aminobutyric acid (GABA) synthesizing enzymes in brains of HIV-infected patients suggest іmpаired GABAergic inhibitory neurotransmission аnalоgous to neurological and psychiatric disorders such as Parkinson’s disеаse and schizophrenia. In this study …
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Optimizing pharmacodynamics and evaluating echocardiographic effects of alfaxalone sedation in bearded dragons (Pogona vitticeps) and prairie rattlesnakes (Crotalus viridis)
… a neurogenic steroid with action at the γ-aminobutyric acid A receptor, is an injectable sedative frequently utilized in squamate medicine. A novel formulation of alfaxalone was recently approved by the Food and Drug Administration for 28-day use after breaching the vial due to the addition …
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Real-time motion and magnetic field correction for GABA editing using EPI volumetric navigated MEGA-SPECIAL sequence: Reproducibility and Gender effects
γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter and is of great interest to the magnetic resonance spectroscopy (MRS) community due to its role in several neurological diseases and disorders. Since GABA acquisition without macromolecule contamination requires long scan times …
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Molecular and ontogenic analysis of the mammalian GABA<sub>A</sub> receptor
γ-aminobutyric acid is the major inhibitory neurotransmitter in the adult mammalian central nervous system (CNS) and may also play a neurotrophic role during CNS development. Diversification of GABA<sub>A</sub> receptor mediated responses are in part a result ofvariation in subunit composition in …
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Characterisation of a Novel GABA Signalling System in the Human Cerebral Vasculature
γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the mammalian brain, underlying diverse functions from the maintenance of consciousness and the formation of memories to the regulation of the processes underlying brain development and circadian rhythms. While GABAergic …
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