Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"γ - Aminobutyric acid (GABA)"”.
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Alcohol alters the expression of Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptors (SNAREs) and spontaneous γ-Aminobutyric Acid (GABA) release...
… We found that alcohol increased gamma-aminobutyric acid (GABA) release via HSF1, but had no effect on glutamatergic synaptic vesicle fusion. Collectively, these data indicate that alcohol induction of HSF1 transcriptional activity triggers a specific coordinated adaptation in GABAergic …
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Detection and Imaging of Neurotransmitters in Rodent Brain Tissue Using FMP-10 and ZnO Nanoparticle Matrices with Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry
… to detect 17 neurochemicals, notably dopamine, γ-aminobutyric acid (GABA), serotonin, and norepinephrine. ZnO NP detects 9 neurochemicals, including glutamate and glutamine, which are undetectable by FMP-10. We applied both matrices to investigate neurochemical changes in male and female …
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Investigation into the role of binding loop E on the function of the nematode cys-loop GABA receptor.
… pocket in Hco-UNC-49BC, the LGCC gated by γ- aminobutyric acid (GABA) within H. contortus. To meet this objective, each amino acid residue in binding loop E was changed to a cysteine and analyzed via electrophysiology and the substituted cysteine accessibility method. It was found that of the …
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Investigation of an unusual GABA-A receptor: studies on the promiscuous ε [epsilon] subunit
γ-aminobutyric acid (GABA) type A (GABAA) receptors are pentameric, chloride-selective ion channels. Nineteen different GABAA receptor subunits are known to exist in man and various subunit combinations are able to form receptor subtypes with different, subunit-specific pharmacological properties. …
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Examination of intramolecular interactions between residues of the cys-loop GABA receptor Hco-UNC-49 from Haemonchus contortus
… Hco-UNC-49 is unique parasitic nematode γ-aminobutyric acid (GABA) gated chloride channel that may prove to be a novel drug target. The objective of this thesis was to characterize intramolecular interactions of Hco-UNC-49B. Two sets of oppositely charged residues were chosen based on their …
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Discovery of Novel Neurologically Active Phytochemicals in Neotropical Piperaceae: An Ethnopharmacological Approach
… the extracts’ in vitro activity on the γ-aminobutyric acid (GABA) system. Plant extracts in general demonstrated moderate to high affinity to the GABA-BZD receptor. Additionally, extracts demonstrated low to moderate activity in the inhibition of the GABA-T enzyme, with a few plants …
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Πορείες συνθέσεως ενώσεων με βιολογικό ενδιαφέρον από 2Η-πυραν-3(6Η)-όνες
… materials. ii) The synthesis of sugaryl-aminoacids (which may be considered as a new class of compounds of pharmacological interest), by Michael addition of aminoacids to 2H-pyran3(6H)-ones and subsequent reduction of the carbonyl group, as well as the stereochemical aspects of the addition. …
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Investigating excitatory GABAergic signalling & benzodiazepine resistance in an in vitro model of status epilepticus
… neurotransmitter within the brain, gamma (γ)-aminobutyric acid (GABA). In a subset of patients however, benzodiazepines prove to be ineffective in terminating SE. Previous data from in vitro models has demonstrated that during single seizures, instead of being inhibitory, activation of the …
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Evaluating the impact of heat stress and altered glycemic state on plasma ɣ-Aminobutyric Acid (GABA) in lactating Holstein cows
… in lactating dairy cows. We hypothesized that γ-aminobutyric acid (GABA) participates in the regulation of this altered glycemic state as it is produced by the pancreatic beta cells and has a stimulatory effect on pancreatic secretion of insulin. Multiparous lactating Holstein cows (n=6; …
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Anomalies of GABAergic system associated with HIV-1 infection
… Findings of lowered concentrations of γ-Aminobutyric acid (GABA) synthesizing enzymes in brains of HIV-infected patients suggest іmpаired GABAergic inhibitory neurotransmission аnalоgous to neurological and psychiatric disorders such as Parkinson’s disеаse and schizophrenia. In this study …
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Real-time motion and magnetic field correction for GABA editing using EPI volumetric navigated MEGA-SPECIAL sequence: Reproducibility and Gender effects
γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter and is of great interest to the magnetic resonance spectroscopy (MRS) community due to its role in several neurological diseases and disorders. Since GABA acquisition without macromolecule contamination requires long scan times …
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Characterisation of a Novel GABA Signalling System in the Human Cerebral Vasculature
γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the mammalian brain, underlying diverse functions from the maintenance of consciousness and the formation of memories to the regulation of the processes underlying brain development and circadian rhythms. While GABAergic …
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Modificazioni neuronali nella via abenulo-mesencefalica durante l’astinenza da Δ9-tetraidrocannabinolo
… exerts a negative control over the VTA via a γ-aminobutyric acid (GABA) structure, the rostromedial tegmental nucleus (RMTg), encoding aversion-related stimuli. In fact, both RMTg and LHb neurons are excited by aversive/unpleasant events and inhibited by rewarding/positive stimuli. Moreover, …
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Neuronal cicuits and reinforcement mechanisms underlying feeding behaviour
… of a subpopulation of homeostatic sensing LHA γ-aminobutyric acid (GABA) expressing neurons. In addition to their response to leptin, these neurons are capable of modulating their activity in response to changes in glucose levels, further substantiating their role as homeostatic sensing neurons. …
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The neurocognitive mechanisms of perceptual inference in autism
… this 7-Tesla MR spectroscopic investigation, γ-Aminobutyric acid (GABA) was measured in the occipital and motor cortices to investigate its role in visuomotor sequential learning and its interactions with autistic traits. Previous findings of a negative relationship between sensorimotor GABA and …
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Metabolomic Analysis of Bacterial Cell Wall Intermediates Using LC-MS/MS: Peptidoglycan Pathway Response to Different Antibiotics
… my thesis describes LC-MS/MS-based resolution of aminobutyric acid isomers (ABA) using linear and Gaussian deconvolution. This approach was then demonstrated for quantification of these species in human serum ⁹. Isomeric molecules present a challenge for analytical resolution and quantification, …
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Processing of acoustic motion in the auditory cortex of the rufous horseshoe bat, Rhinolophus rouxi
… using microiontophoretic application of γ-aminobutyric acid (GABA) and the GABAA receptor antagonist bicuculline methiodide (BMI). In the first part of the study, responses of a total of 152 neurons were recorded. Seventy-one percent of sampled neurons were motion-direction sensitive. Two …
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THE CHARACTERIZATION AND REGULATION OF BENZODIAZEPINE BINDING SITES IN THE MAMMALIAN RETINA, CEREBRAL CORTEX AND KIDNEY
… (K(d)) during development were not observed. γ-Aminobutyric acid (GABA) has previously been shown to increase the affinity of [³H]FLU binding in the adult rat brain; in the present studies this effect was shown to be present throughout the development of the mouse brain. Kinetic analyses of the …
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Synapse Dysfunction Induced by Autism Spectrum Disorder Associated Shank3 Mutations
… Shank3 levels, Shank3 short hairpin ribonucleic acid (shRNA) to down-regulate Shank3 expression, or mutant forms of Shank3 that have been identified in people with ASDs including R87C and R375C point mutations, and the InsG frameshift mutation. The first part of this thesis aimed to investigate …
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Unravelling the role of Bacteroides and Phocaeicola in the human gut: exploring evolutionary dynamics, mother-to-infant vertical transmission, and functional characteristics
… also carried out. Metabolomics analyses and γ-aminobutyric acid (GABA) production was carried out in a subset of the isolates. Metagenomic analysis showed that Bacteroides are absent in CS children who were not exposed to antibiotics before birth, but present in CS-born children whose mothers …
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