Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"γδ T cell"”.
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Killer Cell Immunoglobulin-Like Receptors Delineate Distinct Phenotypes and Functions in Human γδ T Cells
Human circulating γδ T cells are broadly classified into three subsets: Vδ1, Vδ2, and Vδ1/2neg populations, with the Vδ2 subset being the most abundant. In this research, I focus on the contribution and interplay of Natural Killer (NK) receptors to the γδ T cell phenotype and function, with …
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Mechanisms of Immunomodulation By Probiotics: Influence of Lactobacilli On Innate and T Cell Immune Responses Induced By Rotavirus Infection and Vaccines
… by probiotic lactobacilli on innate and T cell immune responses induced by rotavirus infection and vaccines in a gnotobiotic pig model of human rotavirus (HRV) infection and vaccination. We first studied the effects of probiotics on antigen-presenting cells (APCs) through TLR activation. We …
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Butyrophilin family genes as putative coeliac disease risk loci
Coeliac disease (CeD) is a T-cell mediated autoimmune enteropathy (1). CeD is triggered by the consumption of gluten, the collective name of a group of proteins present in wheat, rye, and barley (1, 2). The prevalence of CeD in the United Kingdom (UK) is around 1% and the number of new CeD …
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Human macrophage model for selective evaluation of CD8⁺ and γδ⁺ cytotoxic T cell function in tuberculosis
The human macrophage cell line U937 was investigated as an in vitro model for human macrophage function in mycobacterial infections. This involved evaluating the ability of differentiated U937 cells to phagocytose Mycobacterium tuberculosis, control intracellular mycobacterial growth, and present …
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Unraveling Molecular Mechanisms Underlying the Development of Unconventional T Cells
… generation of a diverse repertoire of mature T cells from precursors derived from the bone marrow. In addition to conventional CD4 and CD8 T cells, innate-like T cells also develop in the thymus and share features of the adaptive and the innate immune system. These ‘unconventional’ T cells have …
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Discerning the Mechanism of Gamma Delta T Cell-Mediated Damage in Multiple Sclerosis: the Potential Role of Antibodies in Disease Pathogenesis
… interested in elucidating the role of the innate γδ T-cell population in MS pathogenesis. In particular, some γδ T-cells that express Fc receptors (FcR), such as CD16, that bind antibody are more prominent with MS disease progression and have been shown to exert cytolysis via antibody-dependent …
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HIGH-THROUGHPUT PROFILING OF INNATE IMMUNE CELLS TO UNVEIL TUMOR ESCAPE MECHANISMS IN MATCHED COLORECTAL CANCER AND LIVER METASTASES
… approaches. To this end, we combined single-cell transcriptomic with paired V(D)J profiling to generate a multi-compartmental innate immune map of synchronous CRC and matched sCRLM, together with circulating blood samples. Our analyses revealed that Tumor-Associated Macrophages (TAMs) and …
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The role of mucus in the cross talk between gut bacteria and the host
… acting as a first line of defence. Furthermore γδ intraepithelial lymphocytes (IELs) respond to the invading bacteria that circumvent the mucus barrier. In this study two approaches were used to investigate the role of mucus in intestinal homeostasis; firstly the impact of γδ IELs on the mucus …
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T Cell Responsiveness Through the Ages: Functional Diversity of Age-Dependent Antiviral Responses
… immunity via the study of repair-associated T cell subsets in pediatric acute respiratory distress syndrome (pARDS), γδ T cells in murine cytomegalovirus (MCMV), and multiple immune mediators and cell populations in adult severe influenza infection. Single-cell RNA sequencing of tracheal …
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γδ T CELLS MEDIATE PROTECTIVE IMMUNE RESPONSES INDUCED BY EILV/CHIKV, A CHIMERA VACCINE CANDIDATE, AGAINST CHIKUNGUNYA INFECTION
… with the inability to replicate in mammalian cells, can provide a novel platform for creating chimeric viruses as vaccine candidates. An EILV/CHIKV chimera that contains the nonstructural proteins of EILV and the structural proteins of CHIKV has previously shown to protect against wild-type …
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Structure, function and inhibition of GcpE, FPPS and GGPPS: targeting isoprenoid biosynthesis for drug discovery
… against HsFPPS and PvGGPPS enzymes as well as cells (Plasmodium parasites), in vitro. Activation of γδ T cell experiment shows similar effects on chain length variation. Crystal structure of HsFPPS bound to BPH-1260, a C4 version of zoledronate with a hydroxyl group on the bisphosphonate group …
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Roles of γδ T Cells in Influenza Infections and Methods for TCR Expression and Characterization
… immune responses associated with immune cell migration/activation and cytokine/chemokine release, can be induced after infections. Recent studies have painted a complex picture of viral clearance and tissue repair in adults. The immune responses in neonatal influenza infections and the …
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Characterisation of the anti-inflammatory potential of ES-62 in autoimmune disease
… to modulate the responses of several innate cells to promote anti-inflammatory immune responses in vitro and in vivo. Indeed, this laboratory demonstrated that ES-62 exhibited anti-inflammatory properties that extended to potential therapeutic action in autoimmune inflammatory diseases such …