Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"γδ T Cells"”.
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Roles of γδ T Cells in Influenza Infections and Methods for TCR Expression and Characterization
… potential methods to engineer antigen-specific T cells for immunotherapy against cancers and infections will be the focus of this dissertation." "Compared to adults, infants suffer higher rates of hospitalization, severe clinical complications, and mortality due to influenza infection. We found …
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Killer Cell Immunoglobulin-Like Receptors Delineate Distinct Phenotypes and Functions in Human γδ T Cells
Human circulating γδ T cells are broadly classified into three subsets: Vδ1, Vδ2, and Vδ1/2neg populations, with the Vδ2 subset being the most abundant. In this research, I focus on the contribution and interplay of Natural Killer (NK) receptors to the γδ T cell phenotype and function, with …
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γδ T CELLS MEDIATE PROTECTIVE IMMUNE RESPONSES INDUCED BY EILV/CHIKV, A CHIMERA VACCINE CANDIDATE, AGAINST CHIKUNGUNYA INFECTION
… with the inability to replicate in mammalian cells, can provide a novel platform for creating chimeric viruses as vaccine candidates. An EILV/CHIKV chimera that contains the nonstructural proteins of EILV and the structural proteins of CHIKV has previously shown to protect against wild-type …
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Discerning the Mechanism of Gamma Delta T Cell-Mediated Damage in Multiple Sclerosis: the Potential Role of Antibodies in Disease Pathogenesis
… interested in elucidating the role of the innate γδ T-cell population in MS pathogenesis. In particular, some γδ T-cells that express Fc receptors (FcR), such as CD16, that bind antibody are more prominent with MS disease progression and have been shown to exert cytolysis via antibody-dependent …
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Phenotypic characterization of stress Leukocytosis
… infusion. Chapter two showed that γδ T cells are mobilized in response to psychological stress and isoproterenol infusion, implicating β-adrenergic mechanisms in this response. Chapter three demonstrated that γδ T cells that were tissue migrating (CD11ahi), of an effector memory …
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T Cell Responsiveness Through the Ages: Functional Diversity of Age-Dependent Antiviral Responses
… acute respiratory distress syndrome (pARDS), γδ T cells in murine cytomegalovirus (MCMV), and multiple immune mediators and cell populations in adult severe influenza infection. Single-cell RNA sequencing of tracheal aspirate cells from pediatric subjects experiencing acute respiratory failure …
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UNCOVERING IMMUNE EVASION MECHANISMS FOR THE PROGNOSIS AND THERAPY OF ENDOMETRIAL AND OVARIAN CANCERS
… frequency, phenotype and function of immune cells in EC and OC patients. In particular, considering that the presence of activated tissue-resident gamma delta (γδ) T cells, recognized for their favorable response in various human malignancies, has been associated with a beneficial response to …
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T cell Immunomodulation in the Lymph Node for Inhibition of Load-Induced Osteoarthritis
… approach targeting specific immune cells. However, the crosstalk of joint pathology with local lymph nodes in OA is poorly understood. We characterized the T cell immune response in local lymph nodes following the in vivo mechanical loading of joints. First, we analyzed the change in …
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THE ROLE OF T-BET IN LUNG INFECTION
… elevated IL-17 production by CD8+, CD4+ and γδ T cells, as well as increased infiltration of neutrophils in the lungs of influenza virus infected T-bet-/- mice contributed to survival advantage against secondary Streptococcus pneumoniae infection. During infection, inverse expression of T-bet …
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Adrenergic Mobilization of the Immune System and the Anti-Cancer Effects of Exercise
… effect on the number and composition of immune cells within the circulation. Within this response, there exists a preferential mobilization of effector lymphocytes with cytotoxic potential, and evidence exists for an anti-tumor effect of exercise dependent upon NK-cells or CD8+ T-cells relative …
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Unraveling Molecular Mechanisms Underlying the Development of Unconventional T Cells
… generation of a diverse repertoire of mature T cells from precursors derived from the bone marrow. In addition to conventional CD4 and CD8 T cells, innate-like T cells also develop in the thymus and share features of the adaptive and the innate immune system. These ‘unconventional’ T cells have …
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Butyrophilin family genes as putative coeliac disease risk loci
… in regulating innate and adaptive immune cells, and in maintaining γδ T-cell subsets (13). Mayassi, et al. (12) have connected the temporary loss of the duodenal butyrophilin heterodimers BTNL3/BTNL8 to the permanent reconfiguration of the local γδ T-cell population in CeD, thus …
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An Investigation into the Potential of Cell Therapies for Acute Myeloid Leukemia (AML) Treatment
… antigen (HLA) matching. Natural killer (NK) cells and gamma delta (γδ) T cells offer alternative effector cell options for cell therapies that do not require HLA-matching and have shown low toxicity in previous studies. In this project, we sought to evaluate FT538 induced pluripotent stem …
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Phenotypic Analysis and Localization of Leukocytes at the Site of Intradermal Injection of Phytohemagglutinin in Chickens
… revealed predominant infiltration of CD4+ T cells and αβ T cells in PHA-injected GFs, with elevated levels observed within 6 h and throughout the 7 d post-injection. B cells and γδ T cells also infiltrated in response to PHA although at lower levels than CD4+ T cells. This is the first report …
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Targeting Airway Microbiome Dysbiosis for Preventing Pediatric Subglottic Stenosis
… in pro-healing macrophages, CD4+, and γδ T cells, among others. Bacterial-host interactions are paramount in the airway for both maintaining homeostasis and driving pathogenesis, which has been observed in many diseases such as rhinosinusitis, asthma, as well as subglottic stenosis. …
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Mechanisms of Immunomodulation By Probiotics: Influence of Lactobacilli On Innate and T Cell Immune Responses Induced By Rotavirus Infection and Vaccines
… the effects of probiotics on antigen-presenting cells (APCs) through TLR activation. We found that a mixture of Lactobacilli acidophilus strain NCFM (LA) and L. reuteri (ATCC# 23272) induced strong TLR2-expressing APC responses and virulent HRV induced a TLR3 response. Probiotics and HRV had an …
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Development of a novel co-vaccination approach for pneumococcal and influenza infections
… vaccine efficacy was shown to be reliant on B cells and IL-17 responses. Importantly, immunisation promoted IL-17 production by γδ T cells, as opposed to conventional Th17 cells commonly reported with other pneumococcal whole cell vaccines. Moreover, this study also illustrated that the …
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Targeting isoprenoid biosynthesis for drug discovery
… inhibition, as well as activation of human γδ T cells to kill extracellular parasites in an indirect manner. In chapter 6, I report the synthesis and characterization of novel Mo, W or V-containing polyoxometalate (POM) bisphosphonate complexes with metal nuclearities ranging from 1 to 6 and …
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Characterisation of the anti-inflammatory potential of ES-62 in autoimmune disease
… to modulate the responses of several innate cells to promote anti-inflammatory immune responses in vitro and in vivo. Indeed, this laboratory demonstrated that ES-62 exhibited anti-inflammatory properties that extended to potential therapeutic action in autoimmune inflammatory diseases such …
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Elucidating the Role of Antigen-presenting Cells in the Immunopathogenesis of the Porcine Reproductive and Respiratory Syndrome Virus
… susceptibility of bone marrow-derived dendritic cells (BMDCs), monocyte-derived dendritic cells (MoDCs), and monocyte-derived macrophages (MoMΦs). After successfully differentiating and characterizing BMDCs from hematopoietic stem cells isolated from the sternum of animals, we demonstrated that …